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  • 二氢青蒿酸

    Dihydroartemisinic acid

    二氢青蒿酸
    产品编号 CFN93295
    CAS编号 85031-59-0
    分子式 = 分子量 C15H24O2 = 236.35
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Artemisia annua L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢青蒿酸 CFN93295 85031-59-0 1mg QQ客服:1457312923
    二氢青蒿酸 CFN93295 85031-59-0 5mg QQ客服:1457312923
    二氢青蒿酸 CFN93295 85031-59-0 10mg QQ客服:1457312923
    二氢青蒿酸 CFN93295 85031-59-0 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Korea Institute of Oriental Medicine (Korea)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University Medical Center Mainz (Germany)
  • Massachusetts General Hospital (USA)
  • Calcutta University (India)
  • Institute of Chinese Materia Medica (China)
  • University of Perugia (Italy)
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  • Deutsches Krebsforschungszentrum (Germany)
  • National Cancer Center Research Institute (Japan)
  • Helmholtz Zentrum München (Germany)
  • University of Hawaii Cancer Center (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2021, 12:635510.
  • J Biomol Struct Dyn.2022, 1-21.
  • PLoS One.2022, 17(4):e0267007.
  • Front Pharmacol.2022, 13:972825.
  • Plant Physiol Biochem.2023, 202:107913.
  • The Korea Society of Pha.2014, 300-314
  • J of L. Chroma.&Related Tech2017, 252-258
  • Functional Ecology2020, doi: 10.1111.
  • Wageningen University & Research2018, January 2018
  • Molecules.2020, 25(7):1625.
  • Int J Mol Sci.2022, 23(5):2796.
  • Int. J of Herbal Med.2023, 11(1): 06-14
  • J Med Food.2016, 19(12):1155-1165
  • Molecules.2022, 27(7):2093.
  • Molecules.2020, 25(21):5087.
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • J Cell Mol Med.2023, jcmm.17968.
  • Nutrients.2020, 12(5):1242.
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
  • Front Plant Sci.2020, 10:1705
  • J Chromatogr B Analyt Technol Biomed Life Sci.2021, 1187:123012.
  • Chem Biodivers.2023, 20(10):e202300741.
  • ...
  • 生物活性
    Description: Dihydroartemisinic acid is a precursor to the antimalarial agent artemisinin.
    In vitro:
    Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E111-8.
    Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.[Pubmed: 22247290]
    Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200 million new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemisinin is a sesquiterpene lactone isolated from the plant Artemisia annua. However, the supply and price of artemisinin fluctuate greatly, and an alternative production method would be valuable to increase availability.
    METHODS AND RESULTS:
    We describe progress toward the goal of developing a supply of semisynthetic artemisinin based on production of the artemisinin precursor amorpha-4,11-diene by fermentation from engineered Saccharomyces cerevisiae, and its chemical conversion to Dihydroartemisinic acid, which can be subsequently converted to artemisinin. Previous efforts to produce artemisinin precursors used S. cerevisiae S288C overexpressing selected genes of the mevalonate pathway [Ro et al. (2006) Nature 440:940-943]. We have now overexpressed every enzyme of the mevalonate pathway to ERG20 in S. cerevisiae CEN.PK2, and compared production to CEN.PK2 engineered identically to the previously engineered S288C strain. Overexpressing every enzyme of the mevalonate pathway doubled artemisinic acid production, however, amorpha-4,11-diene production was 10-fold higher than artemisinic acid. We therefore focused on amorpha-4,11-diene production. Development of fermentation processes for the reengineered CEN.PK2 amorpha-4,11-diene strain led to production of > 40 g/L product.
    CONCLUSIONS:
    A chemical process was developed to convert amorpha-4,11-diene to Dihydroartemisinic acid, which could subsequently be converted to artemisinin. The strains and procedures described represent a complete process for production of semisynthetic artemisinin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.231 mL 21.1551 mL 42.3101 mL 84.6203 mL 105.7753 mL
    5 mM 0.8462 mL 4.231 mL 8.462 mL 16.9241 mL 21.1551 mL
    10 mM 0.4231 mL 2.1155 mL 4.231 mL 8.462 mL 10.5775 mL
    50 mM 0.0846 mL 0.4231 mL 0.8462 mL 1.6924 mL 2.1155 mL
    100 mM 0.0423 mL 0.2116 mL 0.4231 mL 0.8462 mL 1.0578 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    alpha-环氧二氢青蒿酸; alpha-Epoxydihydroartemisinic acid CFN98613 380487-65-0 C15H24O3 = 252.4 5mg QQ客服:2159513211
    Alpiniaterpene A; Alpiniaterpene A CFN96782 1448667-05-7 C16H22O4 = 278.34 5mg QQ客服:1457312923
    (1R,2R,3S,4R)-2-甲酰基-4-甲基-alpha-亚甲基-3-(3-氧代丁基)环己烷乙酸; 4,5-Dioxo-4,5-seco-11(13)-cadinen-12-oic acid CFN99430 137288-61-0 C15H22O4 = 266.3 5mg QQ客服:2056216494
    青蒿素A; Arteannuin A CFN97308 82442-48-6 C13H18O2 = 206.3 5mg QQ客服:2056216494
    青蒿素M; Arteannuin M CFN98044 207446-90-0 C15H24O4 = 268.4 5mg QQ客服:2056216494
    青蒿素L; Arteannuin L CFN98043 207446-89-7 C15H22O3 = 250.3 5mg QQ客服:1413575084
    青蒿素B; Arteannuin B CFN98807 50906-56-4 C15H20O3 = 248.3 20mg QQ客服:1457312923
    8alpha-Methacryloyloxy-13-ethoxyvernojalcanolide; 8alpha-Methacryloyloxy-13-ethoxyvernojalcanolide CFN89154 142891-14-3 C25H34O11 = 510.53 5mg QQ客服:2056216494
    10beta-Hydroxycadina-4,11(13)-dien-12,8beta-olide; 10beta-Hydroxycadina-4,11(13)-dien-12,8beta-olide CFN89143 35001-23-1 C15H20O3 = 248.32 5mg QQ客服:3257982914
    二氢青蒿酸; Dihydroartemisinic acid CFN93295 85031-59-0 C15H24O2 = 236.35 5mg QQ客服:215959384

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