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  • 洋地黄毒甙

    Digitoxin

    洋地黄毒甙
    产品编号 CFN98535
    CAS编号 71-63-6
    分子式 = 分子量 C41H64O13 = 764.94
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Digitalis purpurea L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    洋地黄毒甙 CFN98535 71-63-6 10mg QQ客服:215959384
    洋地黄毒甙 CFN98535 71-63-6 20mg QQ客服:215959384
    洋地黄毒甙 CFN98535 71-63-6 50mg QQ客服:215959384
    洋地黄毒甙 CFN98535 71-63-6 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Charles Sturt University (Denmark)
  • Massachusetts General Hospital (USA)
  • Universit?t Basel (Switzerland)
  • University of Indonesia (Indonesia)
  • University of Toulouse (France)
  • CSIRO - Agriculture Flagship (Australia)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Kyushu University (Japan)
  • University of Vigo (Spain)
  • Shanghai Institute of Organic Chemistry (China)
  • Yale University (USA)
  • Gyeongsang National University (Korea)
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  • Agricultural Research Organization (ARO) (Israel)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochemistry2018, 15:83-92
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • Asian Pac J Tropical Bio.2020, 10(6):239-247
  • Natural Product Communications2022, 7(3):1-7.
  • Molecules.2022, 27(22):7887.
  • Int J Mol Sci.2015, 16(8):18396-411
  • Antioxidants (Basel).2020, 9(2): E119
  • J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
  • Phytomedicine.2019, 57:95-104
  • Food Chem Toxicol.2023, 176:113802.
  • Pharmaceuticals (Basel).2022, 15(5):591.
  • Int J Mol Sci.2021, 22(12):6466.
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Earth Environ. Sci. 2021, 905:012080.
  • Front. Physiol.2022, 790345.
  • APMIS.2019, 127(10):688-695
  • Industrial Crops and Products2020, 146:112186
  • Front Pharmacol.2021, 12:762829.
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • American Association for Anatomy2020, doi: 10.1002.
  • Academic J of Second Military Medical University2019, 40(1)
  • ...
  • 生物活性
    Description: The cardiac glycosides digitoxin and digoxin have been used in cardiac diseases for many years, digitoxin also has growth inhibition activity in three human cancer cell line, digitoxin activates pro-apoptotic, anti-proliferative signaling cascades and cell cycle arrest. Digitoxin could as a candidate drug for suppressing IL-8-dependent lung inflammation in cystic fibrosis (CF), it can suppress hypersecretion of IL-8 from cultured cystic fibrosis (CF) lung epithelial cells, the specific mechanism is to block phosphorylation of the inhibitor of NF-kappa.Digitoxin actively inhibits Herpes simplex virus type 1 (HSV-1) replication with a 50% effective concentration (EC(50)) of 0.05 microM, the inhibitory effects of digitoxin are likely to be introduced at the early stage of HSV-1 replication and the virus release stage.
    Targets: Chk | p53 | IL Receptor | NF-kB | HSV-1
    In vitro:
    Anticancer Drugs. 2014 Jan;25(1):44-52.
    Digitoxin sensitizes glioma cells to TRAIL-mediated apoptosis by upregulation of death receptor 5 and downregulation of survivin.[Pubmed: 24045365]
    Glioblastoma multiforme is the most lethal and aggressive astrocytoma among primary brain tumors in adults. However, most glioblastoma cells have been reported to be resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.
    METHODS AND RESULTS:
    Here, we have shown that digitoxin (DT), a clinically approved cardiac glycoside for heart failure, can induce TRAIL-mediated apoptosis of glioblastoma cells. DT in noncytotoxic doses (20 nmol/l) can increase TRAIL-induced apoptosis in TRAIL-resistant U87MG glioblastoma cells. Treatment with DT led to apoptosis and a robust reduction in the levels of the antiapoptotic protein survivin by inducing its proteasomal degradation; however, it did not affect the levels of many other apoptosis regulators. Moreover, silencing survivin with small interfering RNAs sensitized glioma cells to TRAIL-induced apoptosis, underscoring the functional role of survivin depletion in the TRAIL-sensitizing actions of DT.
    CONCLUSIONS:
    We demonstrate that inactivation of survivin and death receptor 5 expression by DT is sufficient to restore TRAIL sensitivity in resistant glioma cells. Our results suggest that combining DT with TRAIL treatments may be useful in the treatment of TRAIL-resistant glioma cells.
    Toxicol Appl Pharmacol. 2012 Jan 1;258(1):51-60.
    Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells.[Pubmed: 22037315]
    Mechanisms of digitoxin-inhibited cell growth and induced apoptosis in human non-small cell lung cancer (NCI-H460) cells remain unclear. Understanding how digitoxin or derivate analogs induce their cytotoxic effect below therapeutically relevant concentrations will help in designing and developing novel, safer and more effective anti-cancer drugs.
    METHODS AND RESULTS:
    In this study, NCI-H460 cells were treated with digitoxin and a synthetic analog D6-MA to determine their anti-cancer activity. Different concentrations of digitoxin and D6-MA were used and the subsequent changes in cell morphology, viability, cell cycle, and protein expressions were determined. Digitoxin and D6-MA induced dose-dependent apoptotic morphologic changes in NCI-H460 cells via caspase-9 cleavage, with D6-MA possessing 5-fold greater potency than digitoxin. In comparison, non-tumorigenic immortalized bronchial and small airway epithelial cells displayed significantly less apoptotic sensitivity compared to NCI-H460 cells suggesting that both digitoxin and D6-MA were selective for NSCLC. Furthermore, NCI-H460 cells arrested in G(2)/M phase following digitoxin and D6-MA treatment. Post-treatment evaluation of key G2/M checkpoint regulatory proteins identified down-regulation of cyclin B1/cdc2 complex and survivin. Additionally, Chk1/2 and p53 related proteins experienced down-regulation suggesting a p53-independent cell cycle arrest mechanism.
    CONCLUSIONS:
    In summary, digitoxin and D6-MA exert anti-cancer effects on NCI-H460 cells through apoptosis or cell cycle arrest, with D6-MA showing at least 5-fold greater potency relative to digitoxin.
    Antiviral Res. 2008 Jul;79(1):62-70.
    Anti-HSV activity of digitoxin and its possible mechanisms.[Pubmed: 18353452 ]
    Herpes simplex virus type 1 (HSV-1) can establish latent infection in the nervous system and usually leads to life-threatening diseases in immunocompromised individuals upon reactivation. Treatment with conventional nucleoside analogue such as acyclovir is effective in most cases, but drug-resistance may arise due to prolonged treatment in immunocompromised individuals.
    METHODS AND RESULTS:
    In this study, we identified an in-use medication, digitoxin, which actively inhibited HSV-1 replication with a 50% effective concentration (EC(50)) of 0.05 microM. The 50% cytotoxicity concentration (CC(50)) of digitoxin is 10.66 microM and the derived selective index is 213. Several structural analogues of digitoxin such as digoxin, ouabain octahydrate and G-strophanthin also showed anti-HSV activity. The inhibitory effects of digitoxin are likely to be introduced at the early stage of HSV-1 replication and the virus release stage.
    CONCLUSIONS:
    The observation that digitoxin can inhibit acyclovir-resistant viruses further implicates that digitoxin represents a novel drug class with distinct antiviral mechanisms from traditional drugs.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3073 mL 6.5365 mL 13.0729 mL 26.1458 mL 32.6823 mL
    5 mM 0.2615 mL 1.3073 mL 2.6146 mL 5.2292 mL 6.5365 mL
    10 mM 0.1307 mL 0.6536 mL 1.3073 mL 2.6146 mL 3.2682 mL
    50 mM 0.0261 mL 0.1307 mL 0.2615 mL 0.5229 mL 0.6536 mL
    100 mM 0.0131 mL 0.0654 mL 0.1307 mL 0.2615 mL 0.3268 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    奥多诺甙H; Odoroside H CFN99868 18810-25-8 C30H46O8 = 534.7 5mg QQ客服:3257982914
    乌沙苷元洋地黄苷; Uzarigenin digitaloside CFN97718 61217-80-9 C30H46O8 = 534.69 5mg QQ客服:215959384
    夹竹桃它罗苷 ; Neritaloside CFN98691 465-13-4 C32H48O10 = 592.7 5mg QQ客服:215959384
    欧夹竹桃苷; Oleandrin CFN98693 465-16-7 C32H48O9 = 576.7 20mg QQ客服:3257982914
    黄夹竹桃乙糖苷; Thevebioside CFN99245 114586-47-9 C36H56O13 = 696.8 5mg QQ客服:1413575084
    17alpha-黄夹竹桃乙糖苷; 17alpha-Thevebioside CFN99246 114613-59-1 C36H56O13 = 696.8 5mg QQ客服:2056216494
    乌扎拉苷; Uzarin CFN70301 20231-81-6 C35H54O14 = 698.8 5mg QQ客服:1457312923
    黄夹甙B; Thevetin B CFN96147 27127-79-3 C42H66O18 = 859.0 5mg QQ客服:2159513211
    g-羊角拗质; g-Strophanthin CFN70427 630-60-4 C29H44O12 = 584.7 5mg QQ客服:215959384
    毒毛旋花子甙元; Strophanthidine CFN70435 66-28-4 C23H32O6 = 404.5 5mg QQ客服:215959384

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