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  • 地戊曲酯

    Didrovaltrate

    地戊曲酯
    产品编号 CFN96822
    CAS编号 18296-45-2
    分子式 = 分子量 C22H32O8 = 424.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The roots of Valeriana glechomifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    地戊曲酯 CFN96822 18296-45-2 1mg QQ客服:1457312923
    地戊曲酯 CFN96822 18296-45-2 5mg QQ客服:1457312923
    地戊曲酯 CFN96822 18296-45-2 10mg QQ客服:1457312923
    地戊曲酯 CFN96822 18296-45-2 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Ohio State University (USA)
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  • University of Bordeaux (France)
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  • University of Bonn (Germany)
  • University of Hertfordshire (United Kingdom)
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  • University of Brasilia (Brazil)
  • Korea Institute of Oriental Medicine (Korea)
  • Massachusetts General Hospital (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Cells.2015, 38(9):765-72
  • J Chromatogr A.2022, 1685:463640.
  • Advances in Traditional Medicine 2021, 21:779-789.
  • Eur J Neurosci.2021, 53(11):3548-3560.
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • Vietnam J. Chem.2023, 61(3),308-317
  • Molecules.2019, 24(2):E343
  • J.Food Processing & Preservation2022, jfpp.16666
  • Toxicol Res.2019, 35(4):371-387
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Biomed Pharmacother.2021, 139:111585.
  • Front Cell Infect Microbiol.2018, 8:292
  • Food Chemistry: X.2022, 2022.100270
  • Sci Rep.2017, 7:40345
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • Nutrients.2021, 13(8):2901.
  • Universitat Stuttgart2022, opus-12200.
  • Int J Mol Sci.2020, 21(9):3392.
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • Molecules.2021, 26(13):4081.
  • J Biol Chem.2014, 289(3):1723-31
  • Pharmaceutics.2022, 14(12):2765.
  • ...
  • 生物活性
    Description: Didrovaltrate shows cytotoxic against human cancer cell lines. Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and probably inhibits I(Ca-L) in its inactive state, which may contribute to its cardiovascular effect.
    Targets: Calcium Channel
    In vitro:
    J Tradit Chin Med. 2012 Sep;32(3):442-5.
    Effect of didrovaltrate on I-calcium current in rabbit ventricular myocytes.[Pubmed: 23297570]
    To investigate the effect of didrovaltrate on L-type calcium current (I(Ca-L)) in rabbit ventricular myocytes.
    METHODS AND RESULTS:
    We used the whole cell patch clamp recording technique. Didrovaltrate at concentrations of 30 microg/ L and 100 microg/L significantly decreased peak I(Ca-L) (I(Ca-Lmax)) from (6.01 +/- 0.48) pA/pF to (3.45 +/- 0.27) pA/pF and (2.16 +/- 0.19) pA/pF (42.6% and 64.1%, n=8, P< 0.01), respectively. Didrovaltrate shifted upwards the current-voltage curves of I(Ca-L) without changing their active, peak and reverse potentials. Didrovaltrate affected the steady-state inactivation of I(Ca-L). The half activation potential (V1/2) was significantly shifted from (-26 +/- 2) to (-36 +/- 3) mV (n=6, P<0.05), with a significant change in the slope factor (k) (from 8.8 +/- 0.8 to 11.1 +/- 0.9, n=6, P<0.05). Didrovaltrate did not affect the activation curve.
    CONCLUSIONS:
    Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and probably inhibits I(Ca-L) in its inactive state, which may contribute to its cardiovascular effect.
    Plant Cell Rep. 2004 Oct;23(4):251-5.
    Control of development and valepotriate production by auxins in micropropagated Valeriana glechomifolia.[Pubmed: 15252693]
    Valeriana glechomifolia is a plant species endemic to southern Brazil that accumulates valepotriates, which are terpene derivatives, in all of its organs. Valepotriates are the presumed sedative generic components of the pharmaceutically used species of Valeriana.
    METHODS AND RESULTS:
    The influence of various concentrations of the auxins indole-3-acetic acid, indole-3-butyric acid and alpha-naphthaleneacetic acid on the growth of micropropagated V. glechomifolia was investigated under conditions of transient and continuous exposure. Changes in the development of roots and shoots as well as the production of the valepotriates acevaltrate, valtrate and didrovaltrate (analyzed by high-performance liquid chromatography) were evaluated.
    CONCLUSIONS:
    The best performance in valepotriate production, growth and survival under ex vitro conditions following plant acclimatization was achieved in the continuous presence of 5.71 microM IAA. When cultured in medium containing IAA plants produced stable levels of valepotriates throughout the entire cultivation period.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3558 mL 11.7788 mL 23.5577 mL 47.1154 mL 58.8942 mL
    5 mM 0.4712 mL 2.3558 mL 4.7115 mL 9.4231 mL 11.7788 mL
    10 mM 0.2356 mL 1.1779 mL 2.3558 mL 4.7115 mL 5.8894 mL
    50 mM 0.0471 mL 0.2356 mL 0.4712 mL 0.9423 mL 1.1779 mL
    100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.4712 mL 0.5889 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Jatamanvaltrate N; Jatamanvaltrate N CFN95670 1395056-08-2 C19H28O8 = 384.4 5mg QQ客服:1413575084
    戊曲酯,缬草三酯; Valepotriate CFN90205 18296-44-1 C22H30O8 = 422.47 20mg QQ客服:215959384
    地戊曲酯; Didrovaltrate CFN96822 18296-45-2 C22H32O8 = 424.49 5mg QQ客服:215959384
    IVHD-valtrate; IVHD-valtrate CFN96823 28325-56-6 C27H40O11 = 540.60 5mg QQ客服:1457312923
    醋戊曲酯; Acevaltrate CFN96825 25161-41-5 C24H32O10 = 480.51 10mg QQ客服:2056216494
    缬草苦苷; Valerosidate CFN96457 29505-31-5 C21H34O11 = 462.49 5mg QQ客服:1457312923
    Valeriotriate B; Valeriotriate B CFN96458 862255-64-9 C27H42O12 = 558.62 5mg QQ客服:3257982914
    Valeriotetrate C; Valeriotetrate C CFN96459 904891-20-9 C37H58O15 = 742.85 5mg QQ客服:215959384
    Jatamanvaltrate B ; Jatamanvaltrate B CFN96826 1134138-66-1 C32H50O13 = 642.73 5mg QQ客服:2056216494
    氯化缬草素; Valechlorine CFN90622 51771-49-4 C22H31ClO8 = 458.93 5mg QQ客服:215959384

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