Info: Read More
  • 中药标准品生产商,产品定制服务
  • 去乙酰华蟾毒它灵

    Desacetylcinobufotalin

    去乙酰华蟾毒它灵
    产品编号 CFN93073
    CAS编号 4099-30-3
    分子式 = 分子量 C24H32O6 = 416.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The glandular body of Bufo bufo gargarizans Cantor.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去乙酰华蟾毒它灵 CFN93073 4099-30-3 1mg QQ客服:2056216494
    去乙酰华蟾毒它灵 CFN93073 4099-30-3 5mg QQ客服:2056216494
    去乙酰华蟾毒它灵 CFN93073 4099-30-3 10mg QQ客服:2056216494
    去乙酰华蟾毒它灵 CFN93073 4099-30-3 20mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • John Innes Centre (United Kingdom)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Massachusetts General Hospital (USA)
  • University of Amsterdam (Netherlands)
  • University of Hawaii Cancer Center (USA)
  • Shanghai University of TCM (China)
  • Universiti Malaysia Pahang (Malaysia)
  • Sri Ramachandra University (India)
  • Universidade do Porto (Portugal)
  • University of Melbourne (Australia)
  • University of Parma (Italy)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Deutsches Krebsforschungszentrum (Germany)
  • Chinese University of Hong Kong (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Pharm Biomed Anal.2019, 172:268-277
  • Am J Chin Med.2022, 1-20.
  • Mol Pharm.2017, 14(9):3164-3177
  • 2023, 24(6):5769.Int J Mol Sci.
  • J Chromatogr A.2017, 1518:46-58
  • Antioxidants (Basel).2021, 10(9):1435.
  • Life Sci.2022, 298:120488.
  • Front Pharmacol.2021, 12:615157.
  • Biomed Sci Letters.2020, 26:319-326
  • Oncotarget.2017, 9(3):4161-4172
  • Biomedicines.2022, 10(5):1170
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Biomolecules.2020, 10(6):925.
  • Nutrients.2022, 14(23):4997.
  • Molecules2021, 26(1),230
  • Food Chem.2017, 221:1135-1144
  • Industrial Crops and Products2018, 353-362
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • Metabolites.2020, 10(12):497.
  • Curr Eye Res.2018, 43(1):27-34
  • Int J Mol Sci.2022, 23(13):7115.
  • HIV Med.2021, 22(8):690-704.
  • Arch Toxicol.2017, 91(10):3225-3245
  • ...
  • 生物活性
    Description: Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines.
    In vitro:
    Applied Mechanics & Materials, 2013, 395-396:587-590.
    The Effect and Mechanism of Apoptosis Induced by Desacetylcinobufotalin (DEBF) in Human Hepatocellular Carcinoma HepG2 Cells[Reference: WebLink]

    METHODS AND RESULTS:
    The cytotoxicity of Desacetylcinobufotalin (DEBF) and apoptosis induced by DEBF was measured. Additionally the mechanism of Apoptosis induced by DEBF was studied through Western blot. The results show DEBF displayed the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279μmol/ml. The expression of Bax was significantly increased and the expression of Bcl-2 was markedly decreased, compared to the control.
    CONCLUSIONS:
    The data suggest DEBF had significant antitumor activity through induction apoptosis via mitochondria pathway.
    Journal of Molecular Catalysis B Enzymatic, 2003, 22(1):89-95.
    Biotransformation of cinobufagin by cell suspension cultures of Catharanthus roseus and Platycodon grandiflorum[Reference: WebLink]
    The biotransformations of cinobufagin (1), an animal-originated bufadienolide, by cell suspension cultures of Catharanthus roseus and Platycodon grandiflorum were investigated.
    METHODS AND RESULTS:
    Incubation for 6 days of 1 with C. roseus yielded four products, Desacetylcinobufotalin (2), 3-epi-desacetylcinobufagin (3), 1β-hydroxyl desacetylcinobufagin (4) and 3-epi-Desacetylcinobufotalin (5), among which 4 is a new compound. Time course investigation revealed that the biotransformation rates of two major products, 2 and 3, reached their highest levels of 44.7 and 16.5%, respectively, on the third day after substrate administration. Compounds 2–5 showed more potent cytotoxic activities against HL-60 cell lines than the parent compound 1. A plausible biotransformation pathway is proposed to account for the formation of the observed products. From the culture supernatant of P. grandiflorum, 2 was isolated in 37.8% yield after 8 days of incubation with 1. Cinobufotalin (6) and desacetylcinobufagin (7) were also obtained as minor products. The two plant suspension cultures exhibited similar transformation patterns on compound 1.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4009 mL 12.0045 mL 24.009 mL 48.0181 mL 60.0226 mL
    5 mM 0.4802 mL 2.4009 mL 4.8018 mL 9.6036 mL 12.0045 mL
    10 mM 0.2401 mL 1.2005 mL 2.4009 mL 4.8018 mL 6.0023 mL
    50 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9604 mL 1.2005 mL
    100 mM 0.024 mL 0.12 mL 0.2401 mL 0.4802 mL 0.6002 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    伪异沙蟾毒精; Bufarenogin CFN90151 17008-65-0 C24H32O6 = 416.51 5mg QQ客服:215959384
    伪异沙蟾毒精; Pseudobufarenogin CFN91017 17008-69-4 C24H32O6 = 416.51 10mg QQ客服:215959384
    蟾毒它灵, 蟾蜍他灵; Bufotaline CFN98545 471-95-4 C26H36O6 = 444.56 20mg QQ客服:1413575084
    酯蟾毒配基,蟾力苏; Resibufogenin CFN98543 465-39-4 C24H32O4 = 384.51 20mg QQ客服:215959384
    酯蟾毒精; Resibufagin CFN91013 20987-24-0 C24H30O5 = 398.49 5mg QQ客服:1413575084
    去乙酰华蟾毒精; Deacetylcinobufagin CFN90579 4026-95-3 C24H32O5 = 400.52 10mg QQ客服:2056216494
    华蟾毒精; Cinobufagin CFN98544 470-37-1 C26H34O6 = 442.55 20mg QQ客服:2056216494
    19-氧化华蟾毒精; 19-Oxocinobufagin CFN91012 24512-59-2 C26H32O7 = 456.53 5mg QQ客服:2159513211
    南美蟾毒精; Marinobufagenin CFN93070 470-42-8 C24H32O5 = 400.51 5mg QQ客服:2159513211
    去乙酰华蟾毒它灵; Desacetylcinobufotalin CFN93073 4099-30-3 C24H32O6 = 416.51 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产