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  • 去氧鬼臼脂素

    Deoxypodophyllotoxin

    去氧鬼臼脂素
    产品编号 CFN99888
    CAS编号 19186-35-7
    分子式 = 分子量 C22H22O7 = 398.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Dysosma versipellis (Hance) M.Cheng ex Ying
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去氧鬼臼脂素 CFN99888 19186-35-7 1mg QQ客服:1413575084
    去氧鬼臼脂素 CFN99888 19186-35-7 5mg QQ客服:1413575084
    去氧鬼臼脂素 CFN99888 19186-35-7 10mg QQ客服:1413575084
    去氧鬼臼脂素 CFN99888 19186-35-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Nanjing University of Chinese Medicine (China)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Auckland (New Zealand)
  • Seoul National University (Korea)
  • Yale University (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of the Basque Country (Spain)
  • University of Liège (Belgium)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Stanford University (USA)
  • Universit?t Basel (Switzerland)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Environ Toxicol.2021, doi: 10.1002
  • Aquaculture2017, 481:94-102
  • Int J Mol Med.2019, 43(6):2516-2522
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Antioxidants (Basel).2020, 9(2): E119
  • Agriculture.2022, 12(3), 342.
  • Food Research2021, 5(1):65-71
  • Nutr Cancer.2022, 1-13.
  • Analytical Methods2018, 10(27)
  • Int J Pharm.2022, 618:121636.
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Cancer Manag Res.2019, 11:483-500
  • Front Neurosci.2019, 13:1091
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Molecules.2020 ,25(16):3697.
  • Pharmaceutics.2022, 14(3):564.
  • Foods.2022, 11(12):1708.
  • Nutraceuticals2022, 2(3),150-161
  • J Biochem Mol Toxicol.2022, e23211.
  • Molecules. 2013, 18(7):7376-88
  • Vietnam Journal of Food Control.2022, 5(2): 115-128.
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • ...
  • 生物活性
    Description: Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. Deoxypodophyllotoxin induces G2 /M cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of ATM, upregulation of p53 and Bax, activation of caspase-3 and -7, and accumulation of PTEN resulting in the inhibition of the Akt pathway. Deoxypodophyllotoxin maybe applicable to treat hyperpigmentation, it decreases UV-induced skin pigmentation of brown guinea pigs.
    Targets: Bcl-2/Bax | Caspase | PARP | NF-kB | IkB | TNF-α | Calcium Channel | p53 | Akt | Antifection | p21 | IKK | PTEN
    In vitro:
    Int J Biochem Cell Biol. 2013 Aug;45(8):1710-9.
    Deoxypodophyllotoxin exerts both anti-angiogenic and vascular disrupting effects.[Pubmed: 23702033]
    The anti-angiogenic and vascular disrupting activities of Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, were examined with several in vitro, ex vivo and/or in vivo models.
    METHODS AND RESULTS:
    First, we demonstrated that DPT significantly inhibits the proliferation, migration and tube formation of endothelial cells and inhibits angiogenesis in rat aortic ring and chick chorioallantoic membrane assays. In further studies, DPT induced cytoskeleton reorganization in endothelial cells, which likely contributed to the anti-angiogenic effect at non-cytotoxic concentrations. DPT treatment at higher concentrations for longer time induced the cell cycle arrest, which may contributes to its anti-proliferation effect and anti-angiogenic activity. And DPT dramatically inducted the expression of cyclin B1 and p21 (WAF1/CIP1). Meanwhile, DPT disrupted capillary-like networks in vitro and newly formed vessels from rat aortic rings. Endothelial cell contraction associated with an increase in F-actin via the Rho/Rho kinase pathway likely contributed to the vascular disrupting activity.
    CONCLUSIONS:
    Taken together, our results provided the initial evidence that DPT exerts potent anti-angiogenic and vascular disrupting effects. This study also provides important insight into the mechanism of action of promising new anticancer drugs with both anti-angiogenic and vascular disrupting activities.
    Molecules. 2015 Jan 20;20(1):1661-75.
    Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in SGC-7901 cells and inhibits tumor growth in vivo.[Pubmed: 25608854]
    Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer effect. However, the in vivo antitumor efficacy of DPT is currently indeterminate.
    METHODS AND RESULTS:
    In this study, we investigated the anti-gastric cancer effects of DPT both in vitro and in vivo. Our data showed that DPT inhibited cancer cell proliferation and induced G2/M cell cycle arrest accompanied by an increase in apoptotic cell death in SGC-7901 cancer cells. In addition, DPT caused cyclin B1, Cdc2 and Cdc25C to accumulate, decreased the expression of Bcl-2 and activated caspase-3 and PARP, suggesting that caspase-mediated pathways were involved in DPT-induced apoptosis. Animal studies revealed that DPT significantly inhibited tumor growth and decreased microvessel density (MVD) in a xenograft model of gastric cancer.
    CONCLUSIONS:
    Taken together, our findings provide a framework for further exploration of DPT as a novel chemotherapeutic for human gastric cancer.
    Neurotoxicology. 2010 Dec;31(6):680-6.
    Pharmacological effect of deoxypodophyllotoxin: a medicinal agent of plant origin, on mammalian neurons.[Pubmed: 20705089 ]
    Deoxypodophyllotoxin (DOP) is a natural product that can be isolated from a variety of medicinal herb plants. It is well known for its antitumor, antiviral, and anti-inflammatory activities. However, there are few investigations that address neurotoxic effect of DOP in animal nervous system.
    METHODS AND RESULTS:
    In this study, whole-cell patch clamp and calcium imaging techniques were employed to investigate effects of DOP on electrophysiological properties and calcium regulation of rat dorsal root ganglion (DRG) neurons. DOP inhibited both TTX-S (tetrodotoxin-sensitive) and TTX-R (tetrodotoxin-resistant) sodium currents in voltage clamp recording and caused a decrease in the number of action potentials (APs) in current clamp experiment. Suppressive and unfavorable effects of DOP on the kinetics of sodium currents in terms of excitability of DRG neurons may greatly contribute to its antitumor and anti-inflammatory activities. Moreover, DOP evoked increase of intracellular Ca(2+) concentrations ([Ca(2+)](i)) in DRG neurons, and this effect may lead to neuronal cytotoxicity.
    Pest Manag Sci. 2004 Nov;60(11):1131-6.
    Insecticidal activity of deoxypodophyllotoxin, isolated from Juniperus sabina L, and related lignans against larvae of Pieris rapae L.[Pubmed: 15532689 ]
    In the course of screening for naturally occurring insecticides from plants from the northwestern part of China, a petroleum ether extract of Juniperus sabina L was found to show insecticidal activity against fifth-instar larvae of Pieris rapae L.
    METHODS AND RESULTS:
    From the extract, an insecticidal compound was isolated by bioassay-guided fractionation. The compound was identified as deoxypodophyllotoxin (1) by comparison of its spectroscopic characteristics with literature data. In bioassays, 1 showed antifeedant activity against fifth-instar larvae of P rapae at 0.05-1.00 g litre(-1) and its AFC50 (concentration for 50% antifeedant activity) values at 12 and 48h were 0.170 and 0.060 g litre(-1), respectively. In that concentration range, all treated insects died within 48 h after treatment and compound 1 showed delayed insecticidal activity. At 0.015-0.100 g litre(-1), 1 showed insecticidal activity, with an LC50 of 0.020 g litre(-1). The related compound deoxypicropodophyllotoxin (2), however, showed lower antifeedant and insecticidal activities than 1 in bioassay.
    CONCLUSIONS:
    This indicated that the trans-lactone ring is an important moiety for enhancing activity in these compounds. Comparison of the insecticidal activities of 1 and another related compound, podophyllotoxin (3), suggested that varying the substituent at C-4 is an exciting possibility for synthesizing more potent analogues.
    Pharmacol Rep . 2017 Oct;69(5):878-884.
    Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells[Pubmed: 28623712]
    Abstract Background: A natural compound deoxypodophyllotoxin (DPT) possesses potent anti-proliferative and anti-tumor properties on several cancer types. It triggers cell cycle arrest followed by apoptosis through various cellular processes. However, it is limited to the action mechanism of DPT-mediated cell death modes via apoptosis and autophagy. Methods: Cell viability assay, morphological changes, annexin-V/propidium iodide (PI) assay, reactive oxygen species (ROS), acridine orange staining, and Western blot analyses were evaluated. Results: We demonstrated that DPT induced both apoptosis and autophagy via production of mitochondrial reactive oxygen species (ROS). DPT suppressed the PI3K/AKT/mTOR signaling cascades to lead autophagy process, resulting from conversion of light chain 3-I (LC3-I) into LC3-II and acidic vesicular organelles (AVOs) formation. Even if DPT-induced ROS were occurred in both apoptosis and autophagy, inhibition of ROS generation enhanced cell viability. Otherwise, 3-methyladeine (3-MA) impeding on autophagy accelerated an apoptotic response caused by DPT. Therefore, these findings suggest that DPT triggers cytoprotective autophagy against cytotoxic apoptosis. Conclusion: Autophagy is required for cell survival by inhibition of apoptosis through down-regulation of PI3K/AKT/mTOR pathway against DPT-induced apoptosis in U2OS cells. Keywords: Apoptosis; DPT; Deoxypodophyllotoxin; ROS; Reactive oxygen species.
    In vivo:
    Planta Med. 2004 May;70(5):474-6.
    Deoxypodophyllotoxin, a naturally occurring lignan, inhibits the passive cutaneous anaphylaxis reaction.[Pubmed: 15124098]
    This study examined the effect of a podophyllotoxin derivative, deoxypodophyllotoxin (anthricin), which is a medicinal herb product isolated from Anthriscus sylvestris Hoffm.
    METHODS AND RESULTS:
    Deoxypodophyllotoxin was tested in a rat PCA (passive cutaneous anaphylaxis) assay by administering deoxypodophyllotoxin intraperitoneally (1.0 to 10 mg/kg, i.p.) and intravenously (0.25 to 1.0 mg/kg, i.v.). Deoxypodophyllotoxin dose-dependently inhibited the PCA reaction activated by anti-dinitrophenyl (DNP) IgE. The PCA inhibitory activity of deoxypodophyllotoxin was stronger than those of prednisolone and indomethacin, which were used as positive controls.
    CONCLUSIONS:
    These results suggest that deoxypodophyllotoxin may be beneficial in regulating the immediate-type allergic reaction.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.51 mL 12.5502 mL 25.1004 mL 50.2008 mL 62.751 mL
    5 mM 0.502 mL 2.51 mL 5.0201 mL 10.0402 mL 12.5502 mL
    10 mM 0.251 mL 1.255 mL 2.51 mL 5.0201 mL 6.2751 mL
    50 mM 0.0502 mL 0.251 mL 0.502 mL 1.004 mL 1.255 mL
    100 mM 0.0251 mL 0.1255 mL 0.251 mL 0.502 mL 0.6275 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异峨参内酯; Isoanthricin CFN92623 17301-70-5 C22H22O7 = 398.4 5mg QQ客服:1413575084
    alpha-盾叶鬼臼素; alpha-Peltatin CFN70412 568-53-6 C21H20O8 = 400.4 5mg QQ客服:3257982914
    (-)-β-盾叶鬼臼素; (-)-beta-Peltatin CFN92699 518-29-6 C22H22O8 = 414.4 5mg QQ客服:2056216494
    (-)-β-盾叶鬼臼素-5-O-β-葡萄糖甙; (-)-beta-Peltatin-5-O-beta-D-glucopyranoside CFN92700 11024-59-2 C28H32O13 = 576.6 5mg QQ客服:1457312923
    去氧鬼臼脂素; Deoxypodophyllotoxin CFN99888 19186-35-7 C22H22O7 = 398.4 10mg QQ客服:1413575084
    4'-去甲鬼臼毒素; 4'-Demethylpodophyllotoxin CFN90483 40505-27-9 C21H20O8 = 400.37 20mg QQ客服:1457312923
    依托泊甙; Etoposide CFN89061 33419-42-0 C29H32O13 = 588.56 20mg QQ客服:1457312923
    Podophyllotoxinone; Podophyllotoxinone CFN91909 477-49-6 C22H20O8 = 412.39 5mg QQ客服:1413575084
    苦鬼臼毒素; Picropodophyllotoxin CFN90443 17434-18-3 C22H22O8 = 414.4 20mg QQ客服:215959384
    鬼臼毒素; Podophyllotoxin CFN99168 518-28-5 C22H22O8 = 414.41 20mg QQ客服:3257982914

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