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  • 曼陀罗萜醇酮

    Daturaolone

    曼陀罗萜醇酮
    产品编号 CFN94010
    CAS编号 41498-80-0
    分子式 = 分子量 C30H48O2 = 440.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Datura stramonium Linn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    曼陀罗萜醇酮 CFN94010 41498-80-0 1mg QQ客服:215959384
    曼陀罗萜醇酮 CFN94010 41498-80-0 5mg QQ客服:215959384
    曼陀罗萜醇酮 CFN94010 41498-80-0 10mg QQ客服:215959384
    曼陀罗萜醇酮 CFN94010 41498-80-0 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Guangzhou Institutes of Biomedicine and Health (China)
  • University of Liège (Belgium)
  • Washington State University (USA)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Northeast Normal University Changchun (China)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Periyar University (India)
  • University of Vienna (Austria)
  • University of Maryland School of Medicine (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Macau University of Science and Technology (China)
  • University of Illinois (USA)
  • Center for protein Engineering (CIP) (Belgium)
  • Wroclaw Medical University (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • University of Central Lancashire2017, 20472
  • Nat Prod Sci.2019, 25(3):238
  • PLoS One.2021, 16(9):e0257243.
  • Int J Mol Sci.2021, 22(17):9400.
  • Plants (Basel).2022, 11(21):2947.
  • Tissue Cell.2022, 75:101728.
  • Int J Mol Sci.2020, 21(9):3239.
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Biochem Biophys Res Commun.2021, 534:802-807.
  • Nature Ecology & Evolution2020, doi: 10.1038
  • Histol Histopathol.2022, 18518.
  • Planta Med.2016, 82(13):1208-16
  • J Plant Biotechnol.2023, 50:070-075.
  • Pharmacol Res.2022, 182:106346.
  • Clin Transl Med.2021, 11(5):e392.
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Foods2023, 12(23), 4342.
  • Int J Mol Sci.2021, 22(14):7324.
  • Food Funct.2021, 12(4):1469-1481.
  • Nutrients.2023, 15(6):1335.
  • Cancer Sci.2022, 113(4):1406-1416.
  • Sains Malaysiana2022, 51(4):1143-1154
  • Int J Mol Sci.2020, 21(19):7209.
  • ...
  • 生物活性
    Description: Daturaolone has potency in reducing the harmful effects or in maintaining the normal hepatic physiological mechanisms in both acute and chronic hepato-toxic induced liver damage in rats. Daturaolone also possesses in vivo anti-inflammatory and antinociceptive potentials, which are supported in silico by an interaction with COXs receptors.
    Targets: COX
    In vivo:
    Evid. Based Complement .Alternat. Med., 2016; 2016: 4098686.
    Biological Evaluation and Docking Analysis of Daturaolone as Potential Cyclooxygenase Inhibitor[Reference: WebLink]
    This study deals with the isolation of the active constituent(s) from a methanolic extract of Pistacia integerrima J. L. Stewart barks and it was also oriented to evaluate the in vivo and in silico anti-inflammatory activity.
    METHODS AND RESULTS:
    By NMR and crystallography techniques, we have isolated a triterpenoid identified as Daturaolone (compound 1). This compound showed in vivo a significant and dose dependent (1-30 mg/kg) anti-inflammatory activity on carrageenan induced mouse paw oedema (ED50= 10.1 mg/kg) and on acetic acid-induced writhing responses in mice (ED50= 13.8 mg/kg). In the in vivo experiments, the effect of tested compound was also evaluated in presence of the reference drug diclofenac (1-30 mg/kg). Moreover, in silico analysis of receptor ligand complex shows that compound 1 interacts with cyclooxygenase (COXs) binding sites displaying an interesting interaction with COX-1.
    CONCLUSIONS:
    These findings suggest that compound 1 isolated from P. integerrima possesses in vivo anti-inflammatory and anti-nociceptive potential, which are supported in silico by an interaction with COXs receptors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2691 mL 11.3453 mL 22.6907 mL 45.3813 mL 56.7266 mL
    5 mM 0.4538 mL 2.2691 mL 4.5381 mL 9.0763 mL 11.3453 mL
    10 mM 0.2269 mL 1.1345 mL 2.2691 mL 4.5381 mL 5.6727 mL
    50 mM 0.0454 mL 0.2269 mL 0.4538 mL 0.9076 mL 1.1345 mL
    100 mM 0.0227 mL 0.1135 mL 0.2269 mL 0.4538 mL 0.5673 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    beta-香树脂醇乙酸酯; beta-Amyrin acetate CFN99679 1616-93-9 C32H52O2 = 468.8 5mg QQ客服:215959384
    beta-软脂酸香树精酯; beta-Amyrin palmitate CFN97009 5973-06-8 C46H80O2 = 665.1 5mg QQ客服:1457312923
    beta-白檀酮; beta-Amyrone CFN97099 638-97-1 C30H48O = 424.7 5mg QQ客服:2056216494
    9(11),12-齐墩果二烯-3beta-醇; 9(11),12-Oleanadien-3-ol CFN97528 94530-87-7 C30H48O = 424.7 5mg QQ客服:2056216494
    齐墩果-12-烯-3b,6b-二醇; 12-Oleanene-3,6-diol CFN94009 41498-79-7 C30H50O2 = 442.72 5 mg QQ客服:3257982914
    曼陀罗萜醇酮; Daturaolone CFN94010 41498-80-0 C30H48O2 = 440.71 5 mg QQ客服:2159513211
    黑果茜草萜 B ; Rubiprasin B CFN96835 125263-66-3 C32H52O4 = 500.76 5mg QQ客服:1457312923
    黑果茜草萜 A ; Rubiprasin A CFN96836 125263-65-2 C32H52O5 = 516.76 5mg QQ客服:1413575084
    13(18)-齐墩果烯-3-醇,Α-香树素; 13(18)-Oleanen-3-ol CFN98801 508-04-3 C30H50O = 426.7 5mg QQ客服:3257982914
    乙酸-delta-香树精酯; delta-Amyrin acetate CFN98820 51361-60-5 C32H52O2 = 468.8 5mg QQ客服:1413575084

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