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  • 盐酸野靛碱

    Cytisine Hydrochloride

    盐酸野靛碱
    产品编号 CFN80438
    CAS编号 6047-01-4
    分子式 = 分子量 C11H14N2O.HCl = 226.70
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Genista tinctoria L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    盐酸野靛碱 CFN80438 6047-01-4 1mg QQ客服:2056216494
    盐酸野靛碱 CFN80438 6047-01-4 5mg QQ客服:2056216494
    盐酸野靛碱 CFN80438 6047-01-4 10mg QQ客服:2056216494
    盐酸野靛碱 CFN80438 6047-01-4 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Ain Shams University (Egypt)
  • University of Illinois (USA)
  • Medical University of Gdansk (Poland)
  • Osmania University (India)
  • Lund University (Sweden)
  • University of Pretoria (South Africa)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int Immunopharmacol.2023, 123:110572.
  • Planta Medica International2022, 9(01):e108-e115.
  • J Ethnopharmacol.2023, 321:117501.
  • J Sep Sci.2021, 44(22):4064-4081.
  • Molecules.2018, 23(7):E1817
  • Journal of Plant Growth Regulation2022, 10705-2.
  • Molecules.2021, 26(12):3652.
  • Biomolecules.2020, 10(6):925.
  • Plants (Basel).2021, 10(11):2525.
  • Oxid Med Cell Longev2019, 9056845:13
  • Functional Ecology2020, doi: 10.1111.
  • Biomolecules.2019, 9(11):E696
  • Enzyme and Microbial Technology2022, 110002.
  • Molecules.2015, 20(10):19172-88
  • Legume Science2021, 3(4): e101.
  • Mol Cells.2018, 41(8):771-780
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Analytical Methods2018, 10(27)
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • National University of Pharmacy2022, 1:73-76
  • Medicinal Chemistry Research 2021, 30:1117-1124.
  • Crystals2020, 10(3), 206.
  • Chem Biol Interact.2020, 328:109200.
  • ...
  • 生物活性
    Description: Cytisine hydrochloride has toxicity.
    In vivo:
    Br J Pharmacol. 1969 Jan;35(1):161-74.
    Some studies on cytisine and its methylated derivatives.[Pubmed: 4387392]

    METHODS AND RESULTS:
    1. In mice Cytisine Hydrochloride is less toxic intravenously than nicotine hydrogen tartrate, but more toxic by intraperitoneal or oral administration. Compared with cytisine, caulophylline hydrogen iodide is one-fifth to one-tenth as toxic and caulophylline methiodide is less than one-thirtieth as toxic.2. The surprising low oral toxicity of cytisine and nicotine may be ascribed to the method of administration; if the drug is placed directly in the stomach there is no possibility of absorption through buccal mucous membranes.3. The peripheral effects of nicotine, cytisine and caulophylline are similar, though on some preparations those of nicotine last longer. In most tests cytisine is active in doses from a quarter to three-quarters of those of nicotine, caulophylline in doses from 10 to 20 times those of cytisine. Caulophylline methiodide is virtually inactive.4. Cytisine and caulophylline may differ from nicotine in their central effects.5. Cytisine and caulophylline are active as the cations. The pKa of cytisine is 7.92 and that of caulophylline is 7.04; the difference accounts, in part, for the weaker activity of caulophylline. The caulophylline ion is generally one-sixth to one-third as active as the cytisine ion.6. The introduction of the second methyl group to form the quaternary salt does not appear to cause a dramatic change in the conformation of the molecule.
    CONCLUSIONS:
    Caulophylline methiodide appears to be feebly active because it has feeble affinity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4111 mL 22.0556 mL 44.1112 mL 88.2223 mL 110.2779 mL
    5 mM 0.8822 mL 4.4111 mL 8.8222 mL 17.6445 mL 22.0556 mL
    10 mM 0.4411 mL 2.2056 mL 4.4111 mL 8.8222 mL 11.0278 mL
    50 mM 0.0882 mL 0.4411 mL 0.8822 mL 1.7644 mL 2.2056 mL
    100 mM 0.0441 mL 0.2206 mL 0.4411 mL 0.8822 mL 1.1028 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-O-乙酰山栀苷甲酯; 8-O-Acetylshanzhiside methyl ester CFN98966 57420-46-9 C19H28O12 = 448.4 20mg QQ客服:2159513211
    表小檗碱; Epiberberine CFN98564 6873-09-2 C20H18NO4 = 336.36 20mg QQ客服:1457312923
    脱水开环异落叶松树脂酚; Anhydrosecoisolariciresinol CFN89236 29388-33-8 C20H24O5 = 344.40 5mg QQ客服:2056216494
    4-甲基七叶亭; 4-Methylesculetin CFN93058 529-84-0 C10H8O4 = 192.17 5mg QQ客服:215959384

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