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  • 环银线草醇A

    Cycloshizukaol A

    环银线草醇A
    产品编号 CFN96270
    CAS编号 150033-85-5
    分子式 = 分子量 C32H36O8 = 548.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Chloranthus spicatus.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    环银线草醇A CFN96270 150033-85-5 1mg QQ客服:1413575084
    环银线草醇A CFN96270 150033-85-5 5mg QQ客服:1413575084
    环银线草醇A CFN96270 150033-85-5 10mg QQ客服:1413575084
    环银线草醇A CFN96270 150033-85-5 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Instituto Politécnico de Bragan?a (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cell Prolif.2021, 54(8):e13083.
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Food Res Int.2022, 157:111207.
  • Phytomedicine Plus2022, 2(1):100207.
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • BMC Complement Altern Med.2014, 14:352
  • Sci Rep.2017, 7:46299
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Processes 2021, 9(5),894.
  • Nutrients.2019, 11(11):E2694
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Journal of Functional Foods2022, 96: 105216.
  • Antioxidants (Basel).2020, 9(6):466.
  • Phytomedicine.2018, 40:37-47
  • Food Chem.2019, 276:768-775
  • Preprints2017, 2017120176
  • J Biomol Struct Dyn.2023, 1-21.
  • ACS Nano.2018, 12(4):3385-3396
  • Plants (Basel).2021, 10(6):1119.
  • Molecules.2021, 26(9):2791.
  • Mol Med Rep.2014, 9(5):1653-9
  • Sci Rep. 2017, 17332(7)
  • Cardiovasc Toxicol.2021, 21(11):947-963.
  • ...
  • 生物活性
    Description: Cycloshizukaol A prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha, it inhibits PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity with MIC values of 0.9 microM.
    Targets: TNF-α
    In vitro:
    J Ethnopharmacol. 2006 Mar 8;104(1-2):270-7.
    Dimeric sesquiterpenoids isolated from Chloranthus japonicus inhibited the expression of cell adhesion molecules.[Pubmed: 16229979 ]

    METHODS AND RESULTS:
    In the search for cell adhesion inhibitors from natural sources, three active compounds were isolated from Chloranthus japonicus Sieb. (Chloranthaceae) roots. The compounds were identified as dimeric sesquiterpenoids of shizukaol B (1), Cycloshizukaol A (2) and shizukaol F (3). These compounds inhibited PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity with MIC values of 34.1 nM (1), 0.9 microM (2) and 27.3 nM (3), respectively. Although 1-3 did not affect the direct binding of LFA-1 to ICAM-1, these compounds markedly inhibited ICAM-1 expression in HL-60 cells in a dose-dependent fashion. On the other hand, when HUVEC were pretreated with 1-3 and stimulated with TNF-alpha, adhesion of THP-1 cells to HUVEC decreased in dose-dependent manner with IC(50) values of 54.6 nM, 1.2 microM and 34.1 nM, respectively. In fact, 1 inhibited TNF-alpha-induced surface expression of the ICAM-1, VCAM-1 and E-selectin in HUVEC with IC(50) values of 5.4 nM, 13.6 microM and 95.6 nM, respectively.
    CONCLUSIONS:
    The present findings suggest that 1-3 prevent monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8228 mL 9.1141 mL 18.2282 mL 36.4564 mL 45.5705 mL
    5 mM 0.3646 mL 1.8228 mL 3.6456 mL 7.2913 mL 9.1141 mL
    10 mM 0.1823 mL 0.9114 mL 1.8228 mL 3.6456 mL 4.5571 mL
    50 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.7291 mL 0.9114 mL
    100 mM 0.0182 mL 0.0911 mL 0.1823 mL 0.3646 mL 0.4557 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    金粟兰交酯F; Shizukanolide F CFN96318 120061-96-3 C15H18O4 = 262.3 5mg QQ客服:3257982914
    金粟兰交酯H; Shizukanolide H CFN99236 1136932-34-7 C17H20O5 = 304.3 5mg QQ客服:215959384
    金粟兰交酯A; Shizukanolide A CFN91953 70578-36-8 C15H18O2 = 230.30 5mg QQ客服:1413575084
    金粟兰内酯E; Chloranthalactone E CFN89177 73215-92-6 C15H18O4 = 262.30 5mg QQ客服:2056216494
    5alpha-羟基金粟兰内酯A; 5alpha-Hydroxychloranthalactone A CFN89181 66395-04-8 C15H16O3 = 244.29 5mg QQ客服:2159513211
    金粟兰内酯A; Chloranthalactone A CFN91950 66395-02-6 C15H16O2 = 228.29 5mg QQ客服:3257982914
    Chlojaponilactone B ; Chlojaponilactone B CFN89106 1449382-91-5 C17H18O4 = 286.32 5mg QQ客服:3257982914
    8-epi-Chlorajapolide F; 8-epi-Chlorajapolide F CFN91951 863301-69-3 C16H20O4 = 276.33 5mg QQ客服:2159513211
    Chlorajapolide F; Chlorajapolide F CFN91952 1461760-59-7 C16H20O4 = 276.33 5mg QQ客服:3257982914
    金粟兰内酯B; Chloranthalactone B CFN91954 66395-03-7 C15H16O3 = 244.29 5mg QQ客服:2056216494

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