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  • 环姜黄素

    Cyclocurcumin

    环姜黄素
    产品编号 CFN95103
    CAS编号 153127-42-5
    分子式 = 分子量 C21H20O6 = 368.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Curcuma longa L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    环姜黄素 CFN95103 153127-42-5 1mg QQ客服:215959384
    环姜黄素 CFN95103 153127-42-5 5mg QQ客服:215959384
    环姜黄素 CFN95103 153127-42-5 10mg QQ客服:215959384
    环姜黄素 CFN95103 153127-42-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universite de Lille1 (France)
  • The Ohio State University (USA)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Texas A&M University (USA)
  • University of Oslo (Norway)
  • Universidad de La Salle (Mexico)
  • Helmholtz Zentrum München (Germany)
  • The University of Newcastle (Australia)
  • University of Sao Paulo (Brazil)
  • Kyushu University (Japan)
  • University of Wuerzburg (Germany)
  • Kazusa DNA Research Institute (Japan)
  • MTT Agrifood Research Finland (Finland)
  • The Institute of Cancer Research (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Food Chem.2016, 191:81-90
  • Molecules.2016, 21(6)
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • J Pharm Anal.2016, 6(6):363-373
  • Polytechnic University of Catalonia2017, 105826
  • J Ethnopharmacol.2017, 197:157-164
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Chemistry of Natural Compounds2018, 204–206
  • Biol Pharm Bull.2018, 41(1):65-72
  • Planta Med.2018, 84(15):1101-1109
  • Wageningen University & Research2018, January 2018
  • Biorxiv2019, 10.1101
  • Biomed Pharmacother.2019, 116:108987
  • Chemistry of Plant Materials.2019, 129-136
  • Microb Pathog.2019, 131:128-134
  • Molecules.2019, 24(10):E1930
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Academic J of Second Military Medical University2019, 40(1)
  • Phytomedicine.2019, 55:229-237
  • Phytomedicine.2019, 57:95-104
  • Plos One.2019, 15(2):e0220084
  • ...
  • 生物活性
    Description: Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. It may have a therapeutic potential as a novel antivasoconstrictive natural product. Cyclocurcumin offers higher neuronal protection than curcumin, they both reduced the level of ROS caused by MPP+ treatment.
    Targets: ROS | NGF | MPP | NADH | TNF-α
    In vitro:
    Sci Rep. 2017 Dec 5;7(1):16977.
    Inhibitory effects of curcumin and cyclocurcumin in 1-methyl-4-phenylpyridinium (MPP+) induced neurotoxicity in differentiated PC12 cells.[Pubmed: 29209088 ]
    Development and progression of neurodegenerative diseases like Parkinson's disease (PD) involve multiple pathways. Thus, effective therapeutic treatments should intervene to address all these pathways simultaneously for greater success. Most of the current pharmacotherapeutic approaches just supplement striatal dopamine. Hence, natural extracts of plants with therapeutic potential have been explored. Curcuminoids belong to one such group of polyphenol which show immense therapeutic effects.
    METHODS AND RESULTS:
    Here, we have used intracellular reactive oxygen species (ROS) measurement, and two-photon fluorescence lifetime imaging microscopy (2P-FLIM) of cellular autofluorescent co-enzyme reduced nicotinamide adenine dinucleotide (NADH) to study the inhibitory effects of curcumin and cyclocurcumin in alleviating PD like neurotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in neuronal growth factor (NGF) induced differentiated PC12 cells. Our results showed that both cyclocurcumin and curcumin reduced the level of ROS caused by MPP+ treatment. Moreover, a significant increase in the free, protein-bound, and average NADH fluorescence lifetimes along with a decrease in the relative contribution of free- vs. protein-bound NADH components in curcuminoids treated cells (pretreated with MPP+) were observed compared with those treated with MPP+ only.
    CONCLUSIONS:
    This study, which indicates that cyclocurcumin offers higher neuronal protection than curcumin, may initiate further studies of these compounds in the cure of neurodegenerative diseases.
    Int J Mol Med. 2017 May;39(5):1164-1172.
    Cyclocurcumin, a curcumin derivative, exhibits immune-modulating ability and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method.[Pubmed: 28339004]
    The control and treatment of rheumatoid arthritis is a challenge in today's world. Therefore, the pursuit of natural disease-modifying antirheumatic drugs (DMRDs) remains a top priority in rheumatology. The present study focused on curcumin and its derivatives in the search for new DMRDs. We focused on prominent p38 mitogen-activated protein (MAP) kinase p38α which is a prime regulator of tumor necrosis factor-α (TNF-α), a key mediator of rheumatoid arthritis.
    METHODS AND RESULTS:
    In the present study, we used the X-ray crystallographic structure of p38α for molecular docking simulations and molecular dynamic simulations to study the binding modes of curcumin and its derivatives with the active site of p38α. The ATP-binding domain was used for evaluating curcumin and its derivatives. Molecular docking simulation results were used to select 4 out of 8 compounds. These 4 compounds were simulated using GROMACS molecular simulation platform; the results generated were subjected to molecular mechanics-Poisson Boltzmann surface area (MM-PBSA) calculations.
    CONCLUSIONS:
    The results showed cyclocurcumin as a potential natural compound for development of a potent DMRD. These data were further supported by inhibition of TNF-α release from lipopolysaccharide (LPS)-stimulated human macrophages following cyclocurcumin treatment.
    J Nat Prod. 2017 Jan 27;80(1):196-200.
    Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric).[Pubmed: 28068085]
    Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood.
    METHODS AND RESULTS:
    Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC50 against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 μM) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity.
    CONCLUSIONS:
    Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in C. longa, may have a therapeutic potential as a novel antivasoconstrictive natural product.
    Mol Nutr Food Res. 2013 Sep;57(9):1529-42.
    Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.[Pubmed: 23847105 ]
    Turmeric, a dried powder derived from the rhizome of Curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, anti-aging, antidiabetic, antimicrobial, wound healing, and memory-enhancing activities. One component of turmeric is curcumin, which has been extensively studied, as indicated by more than 5600 citations, most of which have appeared within the past decade. Recent research has identified numerous chemical entities from turmeric other than curcumin. It is unclear whether all of the activities ascribed to turmeric are due to curcumin or whether other compounds in turmeric can manifest these activities uniquely, additively, or synergistically with curcumin.
    METHODS AND RESULTS:
    However, studies have indicated that turmeric oil, present in turmeric, can enhance the bioavailability of curcumin. Studies over the past decade have indicated that curcumin-free turmeric (CFT) components possess numerous biological activities including anti-inflammatory, anticancer, and antidiabetic activities. Elemene derived from turmeric is approved in China for the treatment of cancer.
    CONCLUSIONS:
    The current review focuses on the anticancer and anti-inflammatory activities exhibited by CFT and by some individual components of turmeric, including turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrone.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4'-O-Methylnyasol; 4'-O-Methylnyasol CFN89281 79004-25-4 C18H18O2 = 266.34 5mg QQ客服:2932563308
    尼亚希木脂素; Nyasicol CFN99213 111518-95-7 C17H16O6 = 316.3 5mg QQ客服:2932563308
    尼亚希木脂素 1,2-丙酮化物; Nyasicol 1,2-acetonide CFN96568 1432057-64-1 C20H20O6 = 356.37 5mg QQ客服:3257982914
    尼亚希木脂素苷; Nyasicoside CFN99212 111518-94-6 C23H26O11 = 478.5 5mg QQ客服:215959384
    Pilosidine; Pilosidine CFN95110 229971-57-7 C23H26O11 = 478.5 5mg QQ客服:2159513211
    八氢姜黄素; Octahydrocurcumin CFN90584 36062-07-4 C21H28O6 = 376.44 20mg QQ客服:215959384
    六氢姜黄素; Hexahydrocurcumin CFN97749 36062-05-2 C21H26O6 = 374.43 5mg QQ客服:3257982914
    四氢姜黄素; Tetrahydrocurcumin CFN90583 36062-04-1 C21H24O6 = 372.41 20mg QQ客服:1413575084
    脱甲氧姜黄; Demethoxycurcumin CFN99185 22608-11-3 C20H18O5 = 338.35 20mg QQ客服:2159513211
    双去甲氧基姜黄素; Bisdemethoxycurcumin CFN99186 33171-05-0 C19H16O4 = 308.33 20mg QQ客服:2159513211

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