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  • 姜黄素

    Curcumin

    姜黄素
    产品编号 CFN98686
    CAS编号 458-37-7
    分子式 = 分子量 C21H20O6 = 368.4
    产品纯度 >=98%
    物理属性 Orange powder
    化合物类型 Phenols
    植物来源 The rhizomatous of Curcuma longa L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    姜黄素 CFN98686 458-37-7 10mg QQ客服:215959384
    姜黄素 CFN98686 458-37-7 20mg QQ客服:215959384
    姜黄素 CFN98686 458-37-7 50mg QQ客服:215959384
    姜黄素 CFN98686 458-37-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Shanghai Institute of Organic Chemistry (China)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • National Chung Hsing University (Taiwan)
  • Universidad Industrial de Santander (Colombia)
  • Hamdard University (India)
  • Monash University (Australia)
  • Medizinische Universit?t Wien (Austria)
  • Wageningen University (Netherlands)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Monash University Malaysia (Malaysia)
  • John Innes Centre (United Kingdom)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Helsinki (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Molecules.2020, 25(23):5556.
  • J Pharm Biomed Anal2016, 118:183-194
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • Arch Pharm Res.2015, 38(6):1080-9
  • Eur J Pharmacol.2021, 906:174220.
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • Sci Rep.2018, 8(1)
  • Front Plant Sci.2017, 8:723
  • Nutrients.2018, 10(7)
  • Plant Physiol Biochem.2023, 202:107913.
  • Journal of Apiculture2019, 34(2):131-136
  • J Biol Chem.2021, 297(6):101362.
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • Environ Toxicol.2020, doi: 10.1002
  • J of L. Chroma.&Related Tech2017, 252-258
  • The Japan Society for Analytical Chemistry2017, 613-617
  • Antioxidants.2022, 11(4), 67.
  • Cancers (Basel).2021, 13(6):1432.
  • Academic J of Second Military Medical University2019, 40(1)
  • ACS Omega.2021, 6(36):23460-23474.
  • Int J Mol Sci.2022, 23(20):12516.
  • Food Chem.2019, 279:80-87
  • ...
  • 生物活性
    Description: Curcumin is a natural phenolic compound with diverse pharmacologic effects including antitumour, anti-bacteria, anti-fungicidal ,anti-edemic, hepatoprotective, anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase ((HATs)) and also shows inhibitory effects on NF-κB and MAPKs.Curcumin application causes markedly fast wound closure with well-formed granulation tissue dominated by fibroblast proliferation, collagen deposition, and complete early regenerated epithelial layer.
    Targets: DNA Methyltransferase | TNF-α | IFN-γ | IL Receptor | Nrf2 | HO-1 | GLUT | Caspase | STAT | NF-kB | HDAC | VEGFR | TGF-β/Smad
    In vitro:
    Toxicol Lett. 2015 Mar 18;233(3):227-38.
    Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells.[Pubmed: 25644192]
    It is widely accepted that abnormal accumulation of vascular smooth muscle cells (VSMCs) may promote atherosclerosis and post-angioplasty restenosis. The use of some plant polyphenols with potent antiproliferative activities may be considered as a therapeutic intervention to diminish/prevent the development of cardiovascular pathologies.
    METHODS AND RESULTS:
    In the present study, VSMC response to curcumin treatment was evaluated. 5 μM curcumin elicited a cytostatic effect, which was accompanied by protein carbonylation, oxidative DNA damage and changes in the nucleolar activity (the size and number of nucleoli, nucleolar protein levels and their localization). The levels of p53 and p21 were elevated. However, this was independent of DNA DSBs. Curcumin caused inhibition of rDNA transcription, which could be due to SIRT7 downregulation, site-specific methylation of RNA18S5 gene promoter or both. Curcumin-induced DNA methyltransferase 2 (DNMT2) upregulation was also shown. DNMT2-mediated RNA methylation could promote RNA stabilization upon curcumin treatment.
    CONCLUSIONS:
    In conclusion, a nucleolus-focused cytostatic action of curcumin at a low micromolar concentration range, which could be feasibly achieved through dietary means, was established in VSMCs and we propose a novel mechanism underlying this action. We believe that our results may contribute to better understanding of the biological and pharmacological effects of curcumin on the human cardiovascular system.
    Anticancer Res. 2015 Feb;35(2):645-51.
    Potential anticancer properties and mechanisms of action of curcumin.[Pubmed: 25667441]
    Curcumin, a yellow substance belonging to the polyphenols superfamily, is the active component of turmeric, a common Indian spice, which is derived from the dried rhizome of the Curcuma longa plant. Numerous studies have demonstrated that curcumin possesses anti-oxidant, anti-inflammatory and anticancerous properties. The purpose of this review is to focus on the anti-tumor effects of curcumin.
    METHODS AND RESULTS:
    Curcumin inhibits the STAT3 and NF-κB signaling pathways, which play key-roles in cancer development and progression. Also, inhibition of Sp-1 and its housekeeping gene expressions may serve as an important hypothesis to prevent cancer formation, migration, and invasion. Recent data have suggested that curcumin may act by suppressing the Sp-1 activation and its downstream genes, including ADEM10, calmodulin, EPHB2, HDAC4, and SEPP1 in a concentration-dependent manner in colorectal cancer cell lines; these results are consistent with other studies, which have reported that curcumin could suppress the Sp-1 activity in bladder cancer and could decrease DNA binding activity of Sp-1 in non-small cell lung carcinoma cells. Recent data advocate that ER stress and autophagy may as well play a role in the apoptosis process, which is induced by the curcumin analogue B19 in an epithelial ovarian tumor cell line and that autophagy inhibition could increase curcumin analogue-induced apoptosis by inducing severe ER stress.
    CONCLUSIONS:
    The ability of curcumin to induce apoptosis in tumor cells and its anti-angiogenic potential will be discussed in this review.
    In vivo:
    Toxicol Appl Pharmacol. 2015 Feb 1;282(3):297-310.
    Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats.[Pubmed: 25541178]
    The phytochemical, curcumin, has been reported to play many beneficial roles. However, under diabetic conditions, the detail mechanism of its beneficial action in the glucose homeostasis regulatory organ, pancreas, is poorly understood.
    METHODS AND RESULTS:
    The present study has been designed and carried out to explore the role of curcumin in the pancreatic tissue of STZ induced and cellular stress mediated diabetes in eight weeks old male Wistar rats. Diabetes was induced with a single intraperitoneal dose of STZ (65 mg/kg body weight). Post to diabetes induction, animals were treated with curcumin at a dose of 100 mg/kg body weight for eight weeks. Underlying molecular and cellular mechanism was determined using various biochemical assays, DNA fragmentation, FACS, histology, immunoblotting and ELISA. Treatment with curcumin reduced blood glucose level, increased plasma insulin and mitigated oxidative stress related markers. In vivo and in vitro experimental results revealed increased levels of proinflammatory cytokines (TNF-α, IL1-β and IFN-γ), reduced level of cellular defense proteins (Nrf-2 and HO-1) and glucose transporter (GLUT-2) along with enhanced levels of signaling molecules of ER stress dependent and independent apoptosis (cleaved Caspase-12/9/8/3) in STZ administered group. Treatment with curcumin ameliorated all the adverse changes and helps the organ back to its normal physiology.
    CONCLUSIONS:
    Results suggest that curcumin protects pancreatic beta-cells by attenuating inflammatory responses, and inhibiting ER/mitochondrial dependent and independent pathways of apoptosis and crosstalk between them. This uniqueness and absence of any detectable adverse effect proposes the possibility of using this molecule as an effective protector in the cellular stress mediated diabetes mellitus.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    四氢姜黄素; Tetrahydrocurcumin CFN90583 36062-04-1 C21H24O6 = 372.41 20mg QQ客服:1413575084
    脱甲氧姜黄; Demethoxycurcumin CFN99185 22608-11-3 C20H18O5 = 338.35 20mg QQ客服:215959384
    双去甲氧基姜黄素; Bisdemethoxycurcumin CFN99186 33171-05-0 C19H16O4 = 308.33 20mg QQ客服:2056216494
    姜黄素; Curcumin CFN98686 458-37-7 C21H20O6 = 368.4 20mg QQ客服:1413575084
    二甲基姜黄素; Dimethylcurcumin CFN90607 52328-98-0 C23H24O6 = 396.43 20mg QQ客服:2159513211
    四甲基姜黄素; Tetramethylcurcumin CFN90605 52328-97-9 C25H28O6 = 424.49 5mg QQ客服:1457312923
    二氢姜黄素; Dihydrocurcumin CFN99540 76474-56-1 C21H22O6 = 370.40 5mg QQ客服:1413575084
    马拉巴酮A; Malabaricone A CFN95477 63335-23-9 C21H26O3 = 326.4 10mg QQ客服:2159513211
    马拉巴酮C; Malabaricone C CFN95475 63335-25-1 C21H26O5 = 358.4 10mg QQ客服:215959384
    Giganteone A; Giganteone A CFN95481 460337-13-7 C42H50O10 = 714.9 5mg QQ客服:3257982914

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