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  • 葫芦素R

    Cucurbitacin R

    葫芦素R
    产品编号 CFN92895
    CAS编号 55903-92-9
    分子式 = 分子量 C30H46O7 = 518.68
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The rhizomes of Hemsleya amabilis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    葫芦素R CFN92895 55903-92-9 1mg QQ客服:1457312923
    葫芦素R CFN92895 55903-92-9 5mg QQ客服:1457312923
    葫芦素R CFN92895 55903-92-9 10mg QQ客服:1457312923
    葫芦素R CFN92895 55903-92-9 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Católica Portuguesa (Portugal)
  • University of Eastern Finland (Finland)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • University of Minnesota (USA)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Kyushu University (Japan)
  • Kyung Hee University (Korea)
  • Melbourne University (Australia)
  • University of Wollongong (Australia)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Malaya (Malaysia)
  • University of Vienna (Austria)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Max-Planck-Insitut (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cell Chem Biol.2019, 26(1):27-34
  • Molecules.2019, 24(7):E1290
  • LWT2020, 124:109163
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Food Funct.2022, D1FO03838A.
  • Drug Des Devel Ther.2020, 14:61-71
  • Mol Med Rep.2022, 25(1):8.
  • J Biosci.2020, 45:46.
  • Biomedicines.2022, 10(2):463.
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Life Sci.2021, 270:119074.
  • J Ethnopharmacol.2023, 321:117501.
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Molecules.2020, 25(9):2111.
  • J Ginseng Res.2020, 44(4):611-618.
  • PLoS One.2017, 12(3):e0173585
  • Int J Mol Sci.2021, 22(8):4211.
  • Food and Fermentation Industries2019, 45(7):45-51
  • Evid Based Complement Alternat Med.2021, 2021:8707280.
  • Journal of Molecular Liquids2021, 334:116014.
  • Applied Biological Chemistry2021, 64(4)
  • Genes Genomics.2020, 10.1007
  • J Breast Cancer.2015, 18(2):112-118
  • ...
  • 生物活性
    Description: Cucurbitacin R, a natural anti-inflammatory product, has been shown to exhibit activity against both adjuvant-induced arthritis and delayed-type hypersensitivity reactions induced by various agents; it has the potential to be a new immunosuppressive agent with antiproliferative effects through the inhibition of the NFAT with anti-inflammatory activity in DTH reactions. Cucurbitacin R can exert antitumorigenic activity in the absence of activated STAT3.
    Targets: Bcl-2/Bax | Caspase | p21 | p53 | IL Receptor | NOS | PGE | TNF-α | COX | STAT
    In vivo:
    J Pharmacol Exp Ther. 2010 Feb;332(2):352-63.
    Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus.[Pubmed: 19846588 ]
    Cucurbitacin R is known to exhibit an anti-inflammatory effect in different experimental models of inflammation.
    METHODS AND RESULTS:
    In this article, we outline the effect of Cucurbitacin R on T lymphocyte proliferation, cytokine production, and nuclear factor activation, as well as its influence on various experimental models of delayed-type hypersensitivity (DTH) in mice. Cucurbitacin R reduced the proliferation of phytohemagglutinin A-stimulated human T lymphocytes (IC(50), 18 microM), modifying the cell cycle, as well as the production of cytokines [interleukin (IL)-2, IL-4, IL-10, and especially interferon-gamma] and the induction of the principal cyclins implicated in the cell cycle (A(1), B(1), D(2), and E). These effects are brought on by a novel, selective inhibition of nuclear factor AT (NFAT) by Cucurbitacin R, with no concomitant effect on other transcription factors such as activator protein-1. In addition, we tested the in vivo effects of Cucurbitacin R in three experimental models of DTH, as well as its effects on T lymphocyte proliferation, the cell cycle, cytokines, and cyclins. Although Cucurbitacin R was found to reduce the inflammatory response brought on by both oxazolone and dinitrofluorobenzene, its activity was even more pronounced against sheep red blood cell-induced edema in mouse paws, with a clear reduction in the production of IL-1beta, IL-4, and tumor necrosis factor alpha in the inflamed paw.
    CONCLUSIONS:
    In conclusion, Cucurbitacin R has the potential to be a new immunosuppressive agent with antiproliferative effects through the inhibition of the NFAT with anti-inflammatory activity in DTH reactions.
    J Pharmacol Exp Ther. 2007 Feb;320(2):581-90.
    Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages.[Pubmed: 17065367 ]
    The aim of this study was to investigate the effects of Cucurbitacin R on an experimental model of adjuvant-induced arthritis in rats.
    METHODS AND RESULTS:
    The treatment of arthritic rats with Cucurbitacin R (1 mg/kg p.o. daily) modified the evolution of the clinical symptoms, whereas the histopathology of paws demonstrated a reduction in the signs of arthritis. Compared with the control group, radiography of the tibiotarsal joints of Cucurbitacin R-treated rats showed a decrease in joint damage and soft tissue swelling of the footpad. The in vivo study of the expression of proinflammatory enzymes (nitric-oxide synthase-2 and cyclooxygenase-2) with the aid of the Western blot technique, and that of tumor necrosis factor-alpha (TNF-alpha) and prostaglandin E(2) by means of enzyme-linked immunosorbent assays demonstrated a clear decrease in both the enzymes and the mediators in paw homogenates. The analysis for prostaglandin E(2), nitric oxide, and TNF-alpha production in RAW 264.7 macrophages, as well as that for TNF-alpha in human lymphocytes, indicated a reduction of all mediators. The expression of cyclooxygenase-2 was not modified in RAW 264.7 macrophages, whereas the expression of nitric-oxide synthase-2 was clearly diminished. Moreover, Cucurbitacin R was found to inhibit signal transducer and activator of transcription 3 activation in the lymphocytes of both healthy and arthritic men.
    CONCLUSIONS:
    These experimental data on the chronic model, together with previously reported activity on acute and subchronic experimental models, justify the anti-inflammatory activity of Cucurbitacin R and provide further evidence for the therapeutic potential of a group of natural products as anti-inflammatory agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.928 mL 9.6399 mL 19.2797 mL 38.5594 mL 48.1993 mL
    5 mM 0.3856 mL 1.928 mL 3.8559 mL 7.7119 mL 9.6399 mL
    10 mM 0.1928 mL 0.964 mL 1.928 mL 3.8559 mL 4.8199 mL
    50 mM 0.0386 mL 0.1928 mL 0.3856 mL 0.7712 mL 0.964 mL
    100 mM 0.0193 mL 0.0964 mL 0.1928 mL 0.3856 mL 0.482 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    四氢异葫芦素I; Tetrahydroisocucurbitacin I CFN92892 3877-89-2 C30H46O7 = 518.68 5mg QQ客服:1457312923
    葫芦素 IIa; 雪胆素甲; Cucurbitacin IIA CFN98171 58546-34-2 C32H50O8 = 562.73 20mg QQ客服:2056216494
    葫芦素Q1; Cucurbitacin Q1 CFN91760 99530-82-2 C32H48O8 = 560.72 10mg QQ客服:3257982914
    葫芦素R; Cucurbitacin R CFN92895 55903-92-9 C30H46O7 = 518.68 5mg QQ客服:2056216494
    二氢葫芦素B; Dihydrocucurbitacin B CFN92140 13201-14-4 C32H48O8 = 560.7 10mg QQ客服:215959384
    法巴森; Fabacein CFN91586 37710-13-7 C34H48O9 = 600.7 5mg QQ客服:2056216494
    Arvenin II; Arvenin II CFN92896 65247-28-1 C38H58O13 = 722.86 5mg QQ客服:1413575084
    Arvenin III; Arvenin III CFN95327 65597-45-7 C36H54O12 = 678.8 5mg QQ客服:2056216494
    葫芦苦素D; Hexanorcucurbitacin D CFN92893 29065-05-2 C24H34O5 = 402.52 5mg QQ客服:1457312923
    葫芦素D; Cucurbitacin D CFN90209 3877-86-9 C30H44O7 = 516.67 10mg QQ客服:3257982914

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