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  • 柯楠次碱

    • 柯楠次碱

    Corynanthine

    柯楠次碱
    		产品编号 CFN70375
    CAS编号 483-10-3
    分子式 = 分子量 C21H26N2O3 = 354.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Corynanthe pachyceras
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柯楠次碱 CFN70375 483-10-3 1mg QQ客服：2159513211
    柯楠次碱 CFN70375 483-10-3 5mg QQ客服：2159513211
    柯楠次碱 CFN70375 483-10-3 10mg QQ客服：2159513211
    柯楠次碱 CFN70375 483-10-3 20mg QQ客服：2159513211
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    3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • The Ohio State University (USA)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Medical University of South Carolina (USA)
  • University of Perugia (Italy)
  • National Cancer Institute (USA)
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  • Universidade Católica Portuguesa (Portugal)
  • Universite Libre de Bruxelles (Belgium)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Max-Planck-Insitut (Germany)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Sapienza University of Rome (Italy)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chemistr of plant2016, 2016021195
  • Universitat Stuttgart2022, opus-12200.
  • J Cell Physiol.2020, 10.1002
  • The Korea Society of Pha.2014, 300-314
  • Planta Med.2018, 84(6-07):465-474
  • Arch Biochem Biophys.2018, 644:93-99
  • Plants (Basel).2021, 10(2):278.
  • Acta horticulturae2017, 1158:257-268
  • Food Sci Nutr.2019, 8(1):246-256
  • Food Chem.2020, 327:126992.
  • Molecules.2023, 28(19):6775.
  • Anal Bioanal Chem.2016, 408(1):177-90.
  • J Ethnopharmacol.2019, 241:112025
  • Heliyon.2022, e12337.
  • Biorxiv2019, 10.1101
  • Fitoterapia.2022, 157:105130.
  • Separations2021, 8(6),80.
  • Nutr Cancer.2022, 1-13.
  • Saf Health Work.2019, 10(2):196-204
  • Am J Chin Med.2023, 51(4):1019-1039.
  • Research Square2021, March 3rd.
  • Sci Rep.2017, 7(1):3249
  • Journal of Ginseng Research2021, 3 June.
  • ...
    • 生物活性
    Description: Corynanthine is an alpha 1-adrenoceptor and alpha 2-adrenoceptor antagonist. Corynanthine inhibits, while idazoxan potentiates, cardiotoxic effects of ouabain. It modulates DNA synthesis in mitogen-stimulated human lymphocytes.
    Targets: alpha 1-adrenoceptor | alpha 2-adrenoceptor | IL Recepter | DNA
    In vitro:
    Naunyn-schmiedeberg's Archives of Pharmacology, 01 Feb 1984, 325(2):136-144.
    Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine.[Reference: WebLink]
    In the present studies the potency and selectivity of idazoxan (RX 781094) were compared with yohimbine and its diastereoisomers rauwolscine and corynanthine in both functional studies and radioligand binding experiments.
    METHODS AND RESULTS:
    Prejunctional alpha 2- and postjunctional alpha 1-adrenoceptor antagonist potencies were assessed by determining pA2 values against clonidine on the stimulated rat was deferens and noradrenaline on the anococcygeus muscle, respectively. The rank order of prejunctional alpha 2-adrenoceptor antagonist potency was idazoxan greater than yohimbine greater than rauwolscine much greater than corynanthine. At postjunctional alpha 1-adrenoceptors the rank order of antagonist potency was rauwolscine greater than corynanthine greater than yohimbine greater than idazoxan. The selectivity values (alpha 2/alpha 1) for idazoxan, yohimbine, rauwolscine and corynanthine were 245, 45, 3 and 0.03 respectively. The selectivity and potency profiles established for these antagonists in functional studies were confirmed in radioligand binding studies utilising 3H-idazoxan (alpha 2) and 3H-prazosin (alpha 1) in rat cerebral cortex. In pithed rats intravenously administered idazoxan, yohimbine and rauwolscine fully reversed the inhibitory effects of clonidine on electrically-induced contractions of the vas deferens; idazoxan was approximately ten times more potent than both yohimbine and rauwolscine. Corynanthine was inactive. Idazoxan and yohimbine also fully antagonised the inhibitory effects of guanabenz on electrically-induced contractions of the anococcygeus muscle; idazoxan again was more than ten times more potent than yohimbine in this model.
    CONCLUSIONS:
    The inhibitory effects of guanabenz were less readily antagonised by rauwolscine indicating that the selectivity of this compound is less than that of yohimbine in this tissue. Corynanthine was again inactive.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8209 mL 14.1044 mL 28.2087 mL 56.4175 mL 70.5219 mL
    5 mM 0.5642 mL 2.8209 mL 5.6417 mL 11.2835 mL 14.1044 mL
    10 mM 0.2821 mL 1.4104 mL 2.8209 mL 5.6417 mL 7.0522 mL
    50 mM 0.0564 mL 0.2821 mL 0.5642 mL 1.1283 mL 1.4104 mL
    100 mM 0.0282 mL 0.141 mL 0.2821 mL 0.5642 mL 0.7052 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    毛冬青皂苷B2; Ilexsaponin B2 CFN93153 108906-69-0 C47H76O17 = 913.10 5mg QQ客服：215959384
    鸦胆苦内酯A; Yadanziolide A CFN96428 95258-14-3 C20H26O10 = 426.41 10mg QQ客服：3257982914
    异银杏双黄酮; Isoginkgetin CFN90174 548-19-6 C32H22O10 = 566.51 20mg QQ客服：215959384
    雷公藤酚E; Wilforol E CFN91914 117456-86-7 C21H30O3 = 330.46 5mg QQ客服：215959384

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