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    Clemastanin B

    产品编号 CFN95064
    CAS编号 112747-98-5
    分子式 = 分子量 C32H44O16 = 684.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Stellera chamaejasme L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    直铁线莲宁B CFN95064 112747-98-5 1mg QQ客服:2159513211
    直铁线莲宁B CFN95064 112747-98-5 5mg QQ客服:2159513211
    直铁线莲宁B CFN95064 112747-98-5 10mg QQ客服:2159513211
    直铁线莲宁B CFN95064 112747-98-5 20mg QQ客服:2159513211
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    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    doi: 10.1016/j.cmet.2020.01.002.

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    doi: 10.1016/j.molcel.2017.10.022.

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    doi: 10.1126/sciadv.aat6994.

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  • 生物活性
    Description: Clemastanin B has antioxidant and anti-inflammatory activities, it exerts its anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment.
    Targets: Influenza virus | Immunology & Inflammation related
    In vitro:
    J Tradit Chin Med. 2016 Jun;36(3):369-76.
    Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis).[Pubmed: 27468553]
    To study the antiviral activities of Clemastanin B (CB), epigoitrin, phenylpropanoids portion (PEP) and the mixture of phenylpropanoids, alkaloids and organic acid fractions (PEP ALK OA) from Banlangen (Radix Isatidis).
    The experiment consisted of four parts: therapeutic action, prophylaxsis action, inhibition of virus attachment, and direct virucidal action. Cytopathic effect (CPE) and 3-(4,5-Dimethylthiazol-2-yI)-2,5-diphenyltetrazolium (MTT) were used to assess antiviral activity. CB, epigoitrin, PEP and PEP ALK OA fractions from Banlangen (Radix Isatidis) extract significantly increased the viability of MDCK cells pre-infected with the virus compared with the virus control group in all the dilutions (P < 0.01). Pretreated with either pure compounds or chemical fractions of Banlangen (Radix Isatidis) extract in all the dilutions significantly improved the viability of MDCK cells (P < 0.01). The inhibition of virus absorption to the host cells by CB, epigoitrin and PEP was in a dose dependent manner.
    CB, epigoitrin, PEP and PEP ALK OA exert their anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. The primary mode of action of PEP and PEP ALK OA is the inhibition of virus replication. The inhibitory effects on virus attachment and multiplication are the main modes for epigoitrin.
    In vivo:
    J Ethnopharmacol. 2014 Nov 18;157:55-61.
    In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion.[Pubmed: 25256688]
    Radix Isatidis called "Ban-Lan-Gen" is one of the most commonly-used traditional Chinese medicines for antiviral, anti-inflammatory, antioxidant and antipyretic purposes. Investigate the bioaccessibility of uridine, epigoitrin, adenosine, clemastanin B, indigoticoside A and isolariciresinol as well as the antioxidant and anti-inflammatory activities during an in vitro gastro-intestinal digestion of the Radix Isatidis extract (RIE).
    High performance liquid chromatography (HPLC) technique was adopted to determine the bioaccessibility of six bioactive compounds in RIE. Antioxidant activities of RIE in different digestive stages were determined by 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide anion and hydroxyl radical scavenging abilities. Anti-inflammatory activity was assayed by the inhibitions of inflammatory cytokines such as nitrous oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor α(TNF-α) producted by lipopolysaccharide (LPS) stimulated RAW264.7 cells. The bioaccessibility of uridine, epigoitrin, adenosine, clemastanin B, indigoticoside A and isolariciresinol were 15.38%, 18.28%, 24.01%, 6.50%, 8.65% and 17.78%, respectively. Also, the digestion products still possessed certain antioxidant activities. The antioxidant activity was highly correlated with lignans (clemastanin B, indigoticoside A and isolariciresino). The anti-inflammation activity of the three samples decreased in the order: IN sample (the solution that had diffused into the dialysis tubing)>Nondigested sample (RIE solution)>Gastric sample (post-gastric digestion)>OUT sample (material that remained in the gastro-intestinal tract).
    Results obtained in this research reveal the amount of bioactive compounds from RIE that could be available for absorption in vivo. The antioxidant activity decreased significantly but the anti-inflammatory activity was enhanced in serum-available fraction after gastro-intestinal digestion in vitro. This study could provide a scientific basis for a deeper pharmacological activity study of Radix Isatidis and a simple method for pharmacodynamic material basis research.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4605 mL 7.3025 mL 14.6049 mL 29.2099 mL 36.5123 mL
    5 mM 0.2921 mL 1.4605 mL 2.921 mL 5.842 mL 7.3025 mL
    10 mM 0.146 mL 0.7302 mL 1.4605 mL 2.921 mL 3.6512 mL
    50 mM 0.0292 mL 0.146 mL 0.2921 mL 0.5842 mL 0.7302 mL
    100 mM 0.0146 mL 0.073 mL 0.146 mL 0.2921 mL 0.3651 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Sanshodiol; Sanshodiol CFN96282 54854-91-0 C20H22O6 = 358.4 5mg QQ客服:1413575084
    (-)-落叶松脂醇; (-)-Lariciresinol CFN92501 83327-19-9 C20H24O6 = 360.4 5mg QQ客服:2159513211
    紫杉脂素; Taxiresinol CFN97744 40951-69-7 C19H22O6 = 346.38 5mg QQ客服:3257982914
    落叶松树脂醇; Lariciresinol CFN98324 27003-73-2 C20H24O6 = 360.4 5mg QQ客服:1413575084
    乙酸落叶松脂酯; Lariciresinol acetate CFN97679 79114-77-5 C22H26O7 = 402.44 5mg QQ客服:1413575084
    9-O-阿魏酰落叶松脂; 9-O-Feruloyllariciresinol CFN97023 60337-67-9 C30H32O9 = 536.6 5mg QQ客服:2056216494
    直铁线莲宁B; Clemastanin B CFN95064 112747-98-5 C32H44O16 = 684.7 10mg QQ客服:3257982914
    橄榄树脂素; Olivil CFN98365 2955-23-9 C20H24O7 = 376.4 5mg QQ客服:2932563308
    Olivil 4'-O-glucoside; Olivil 4'-O-glucoside CFN89274 76880-93-8 C26H34O12 = 538.54 5mg QQ客服:3257982914
    左旋马尾松树脂醇; Massoniresinol CFN97541 96087-10-4 C20H24O8 = 392.4 5mg QQ客服:1457312923





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