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    直铁线莲宁B

    Clemastanin B

    直铁线莲宁B
    产品编号 CFN95064
    CAS编号 112747-98-5
    分子式 = 分子量 C32H44O16 = 684.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Stellera chamaejasme L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    直铁线莲宁B CFN95064 112747-98-5 1mg QQ客服:215959384
    直铁线莲宁B CFN95064 112747-98-5 5mg QQ客服:215959384
    直铁线莲宁B CFN95064 112747-98-5 10mg QQ客服:215959384
    直铁线莲宁B CFN95064 112747-98-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vigo (Spain)
  • University of Parma (Italy)
  • University Medical Center Mainz (Germany)
  • Anna University (India)
  • University of Auckland (New Zealand)
  • University of Bordeaux (France)
  • Wageningen University (Netherlands)
  • University of Limpopo (South Africa)
  • Complutense University of Madrid (Spain)
  • Korea Food Research Institute(KFRI) (Korea)
  • Donald Danforth Plant Science Center (USA)
  • Northeast Normal University Changchun (China)
  • University of Beira Interior (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Pharmacogn Mag.2015, 11:S585-91
  • Inflammation.2015, 38(4):1502-16
  • Oncotarget.2015, 6(31):30831-49
  • Phytochem Anal.2016, 27(5):296-303
  • Mol Immunol. 2016, 78:121-132
  • J Ethnopharmacol.2017, 209:305-316
  • Integr Med Res.2017, 6(4):395-403
  • Sci Rep. 2017, 8207(7)
  • Microchemical Journal2018, 137:168-173
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Int J Mol Sci.2018, 19(2)
  • Chemistry of Natural Compounds2018, 204–206
  • J Sep Sci.2018, 41(7):1682-1690
  • Biomed Pharmacother.2019, 116:108987
  • Neuropharmacology2019, 151437
  • Molecules.2019, 24(11):E2044
  • Food Chem.2019, 276:768-775
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Process Biochemistry2019, 85:106-115
  • Process Biochemistry2019, 87:213-220
  • Food Chem Toxicol.2020, 135:110863
  • ...
  • 生物活性
    Description: Clemastanin B has antioxidant and anti-inflammatory activities, it exerts its anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment.
    Targets: Influenza virus | Immunology & Inflammation related
    In vitro:
    J Tradit Chin Med. 2016 Jun;36(3):369-76.
    Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis).[Pubmed: 27468553]
    To study the antiviral activities of Clemastanin B (CB), epigoitrin, phenylpropanoids portion (PEP) and the mixture of phenylpropanoids, alkaloids and organic acid fractions (PEP ALK OA) from Banlangen (Radix Isatidis).
    METHODS AND RESULTS:
    The experiment consisted of four parts: therapeutic action, prophylaxsis action, inhibition of virus attachment, and direct virucidal action. Cytopathic effect (CPE) and 3-(4,5-Dimethylthiazol-2-yI)-2,5-diphenyltetrazolium (MTT) were used to assess antiviral activity. CB, epigoitrin, PEP and PEP ALK OA fractions from Banlangen (Radix Isatidis) extract significantly increased the viability of MDCK cells pre-infected with the virus compared with the virus control group in all the dilutions (P < 0.01). Pretreated with either pure compounds or chemical fractions of Banlangen (Radix Isatidis) extract in all the dilutions significantly improved the viability of MDCK cells (P < 0.01). The inhibition of virus absorption to the host cells by CB, epigoitrin and PEP was in a dose dependent manner.
    CONCLUSIONS:
    CB, epigoitrin, PEP and PEP ALK OA exert their anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. The primary mode of action of PEP and PEP ALK OA is the inhibition of virus replication. The inhibitory effects on virus attachment and multiplication are the main modes for epigoitrin.
    In vivo:
    J Ethnopharmacol. 2014 Nov 18;157:55-61.
    In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion.[Pubmed: 25256688]
    Radix Isatidis called "Ban-Lan-Gen" is one of the most commonly-used traditional Chinese medicines for antiviral, anti-inflammatory, antioxidant and antipyretic purposes. Investigate the bioaccessibility of uridine, epigoitrin, adenosine, clemastanin B, indigoticoside A and isolariciresinol as well as the antioxidant and anti-inflammatory activities during an in vitro gastro-intestinal digestion of the Radix Isatidis extract (RIE).
    METHODS AND RESULTS:
    High performance liquid chromatography (HPLC) technique was adopted to determine the bioaccessibility of six bioactive compounds in RIE. Antioxidant activities of RIE in different digestive stages were determined by 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide anion and hydroxyl radical scavenging abilities. Anti-inflammatory activity was assayed by the inhibitions of inflammatory cytokines such as nitrous oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor α(TNF-α) producted by lipopolysaccharide (LPS) stimulated RAW264.7 cells. The bioaccessibility of uridine, epigoitrin, adenosine, clemastanin B, indigoticoside A and isolariciresinol were 15.38%, 18.28%, 24.01%, 6.50%, 8.65% and 17.78%, respectively. Also, the digestion products still possessed certain antioxidant activities. The antioxidant activity was highly correlated with lignans (clemastanin B, indigoticoside A and isolariciresino). The anti-inflammation activity of the three samples decreased in the order: IN sample (the solution that had diffused into the dialysis tubing)>Nondigested sample (RIE solution)>Gastric sample (post-gastric digestion)>OUT sample (material that remained in the gastro-intestinal tract).
    CONCLUSIONS:
    Results obtained in this research reveal the amount of bioactive compounds from RIE that could be available for absorption in vivo. The antioxidant activity decreased significantly but the anti-inflammatory activity was enhanced in serum-available fraction after gastro-intestinal digestion in vitro. This study could provide a scientific basis for a deeper pharmacological activity study of Radix Isatidis and a simple method for pharmacodynamic material basis research.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4605 mL 7.3025 mL 14.6049 mL 29.2099 mL 36.5123 mL
    5 mM 0.2921 mL 1.4605 mL 2.921 mL 5.842 mL 7.3025 mL
    10 mM 0.146 mL 0.7302 mL 1.4605 mL 2.921 mL 3.6512 mL
    50 mM 0.0292 mL 0.146 mL 0.2921 mL 0.5842 mL 0.7302 mL
    100 mM 0.0146 mL 0.073 mL 0.146 mL 0.2921 mL 0.3651 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Olivil 4'-O-glucoside; Olivil 4'-O-glucoside CFN89274 76880-93-8 C26H34O12 = 538.54 5mg QQ客服:1413575084
    左旋马尾松树脂醇; Massoniresinol CFN97541 96087-10-4 C20H24O8 = 392.4 5mg QQ客服:2159513211
    橄榄树脂素9-乙酸酯; Olivil monoacetate CFN97860 1016974-78-9 C22H26O8 = 418.44 5mg QQ客服:2932563308
    Fargesol; Fargesol CFN95027 128855-64-1 C22H28O7 = 404.5 20mg QQ客服:2932563308
    9-O-Acetyl-fargesol; 9-O-Acetyl-fargesol CFN95031 449172-61-6 C24H30O8 = 446.5 5mg QQ客服:215959384
    5'-甲氧基落叶松脂素; 5'-Methoxylariciresinol CFN96706 105256-12-0 C21H26O7 = 390.43 5mg QQ客服:3257982914
    Justiciresinol; Justiciresinol CFN92502 136051-41-7 C21H26O7 = 390.4 5mg QQ客服:2159513211
    刺五加酮; Ciwujiatone CFN89318 218901-26-9 C22H26O9 = 434.44 5mg QQ客服:215959384
    5,5'-二甲氧基落叶松脂素; 5,5'-Dimethoxylariciresinol CFN99265 116498-58-9 C22H28O8 = 420.5 5mg QQ客服:1413575084
    9-O-阿魏酰基-5,5'-二甲氧基落叶松树脂醇; 9-O-Feruloyl-5,5'-dimethoxylariciresinol CFN99700 166322-14-1 C32H36O11 = 596.6 5mg QQ客服:2932563308

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