Cinnamyl caffeate

	产品编号	CFN89444
	CAS编号	115610-32-7
	分子式 = 分子量	C₁₈H₁₆O₄ = 296.31
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenylpropanoids
	植物来源	From Chinese propolis.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Cinnamyl caffeate	CFN89444	115610-32-7	1mg	QQ客服：2056216494
Cinnamyl caffeate	CFN89444	115610-32-7	5mg	QQ客服：2056216494
Cinnamyl caffeate	CFN89444	115610-32-7	10mg	QQ客服：2056216494
Cinnamyl caffeate	CFN89444	115610-32-7	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Instituto de Investigaciones Agropecuarias (Chile)

Hamdard University (India)

Nicolaus Copernicus Uniwersity (Poland)

Sri Ramachandra University (India)

Rio de Janeiro State University (Brazil)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Universitas islam negeri Jakarta (Indonesia)

University of Minnesota (USA)

University of Malaya (Malaysia)

Charles Sturt University (Denmark)

Chang Gung University (Taiwan)

CSIRO - Agriculture Flagship (Australia)

Tokyo Woman's Christian University (Japan)

Korea Intitute of Science and Technology (KIST) (Korea)

More...

Description:

Cinnamyl caffeate has cardiovascular protective effects, it can increase H9c2 cellular antioxidant potential, decrease intracellular calcium ion ([Ca2+]i) level, and prevent cell apoptosis; it possesses potent antiproliferative activity with the EC(50) value of 0.114 microM, toward colon 26-L5 carcinoma. Cinnamyl caffeate possesses potent NO inhibitory activity with the IC(50) value of 9.53 microM.

Targets:

Calcium Channel | NO

In vitro:

Evid Based Complement Alternat Med. 2017;2017:7074147

Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells.[Pubmed: 28337227 ]

Chinese propolis (CP) is known as a health food but its beneficial effects in protecting cardiomyocytes remain elusive.
METHODS AND RESULTS:
Here, we investigated the effects of CP and its active compounds on hydrogen peroxide (H2O2) induced rats cardiomyocytes (H9c2) oxidative injury. Cell viability decreases induced by H2O2 were mitigated by different CP extracts using various solvents. From these active fractions, six active compounds were separated and identified. Among tested isolated compound, the cytoprotective activities of three caffeates, caffeic acid phenethyl ester (CAPE), benzyl caffeate (BZC), and Cinnamyl caffeate (CNC), exerted stronger effects than chrysin, pinobanksin, and 3,4-dimethoxycinnamic acid (DMCA). These three caffeates also increased H9c2 cellular antioxidant potential, decreased intracellular calcium ion ([Ca2+]i) level, and prevented cell apoptosis.
CONCLUSIONS:
Overall, the cardiovascular protective effects of the CP might be attributed to its caffeates constituents (CAPE, BZC, and CNC) and provide evidence for its usage in complementary and alternative medicine.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Trans-咖啡酸; Trans-caffeic acid	CFN92549	501-16-6	C₉H₈O₄ = 180.2	20mg	QQ客服：2159513211
咖啡酸甲酯; Methyl caffeate acid	CFN95561	3843-74-1	C₁₀H₁₀O₄ = 194.18	5mg	QQ客服：3257982914
咖啡酸乙酯; Ethyl caffeate	CFN97136	66648-50-8	C₁₁H₁₂O₄ = 208.2	20mg	QQ客服：3257982914
咖啡酸苯乙酯; Caffeic acid phenethyl ester	CFN90554	104594-70-9	C₁₇H₁₆O₄ = 284.31	20mg	QQ客服：2159513211
Nepetoidin B; Nepetoidin B	CFN96779	55486-06-1	C₁₇H₁₄O₆ = 314.29	5mg	QQ客服：2159513211
Cinnamyl caffeate; Cinnamyl caffeate	CFN89444	115610-32-7	C₁₈H₁₆O₄ = 296.31	5mg	QQ客服：1457312923
香豆酸肉桂酯; Cinnamyl coumarate	CFN89462	115610-30-5	C₁₈H₁₆O₃ = 280.31	5mg	QQ客服：2056216494
(E)-Cinnamyl-(Z)-p-coumarate; (E)-Cinnamyl-(Z)-p-coumarate	CFN89417	391682-51-2	C₁₈H₁₆O₃ = 280.31	5mg	QQ客服：1413575084
异阿魏酸肉桂酯; Cinnamyl isoferulate	CFN89441	115610-31-6	C₁₉H₁₈O₄ = 310.34	5mg	QQ客服：215959384
升麻消旋体A; Cimiracemate A	CFN95608	478294-16-5	C₁₉H₁₈O₇ = 358.4	10mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3748 mL	16.8742 mL	33.7484 mL	67.4969 mL	84.3711 mL
5 mM	0.675 mL	3.3748 mL	6.7497 mL	13.4994 mL	16.8742 mL
10 mM	0.3375 mL	1.6874 mL	3.3748 mL	6.7497 mL	8.4371 mL
50 mM	0.0675 mL	0.3375 mL	0.675 mL	1.3499 mL	1.6874 mL
100 mM	0.0337 mL	0.1687 mL	0.3375 mL	0.675 mL	0.8437 mL