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  • 大黄酚-8-O-葡萄糖苷

    Chrysophanol 8-O-glucoside

    大黄酚-8-O-葡萄糖苷
    产品编号 CFN99410
    CAS编号 13241-28-6
    分子式 = 分子量 C21H20O9 = 416.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Anthraquinones
    植物来源 The roots of Rheum emodi.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大黄酚-8-O-葡萄糖苷 CFN99410 13241-28-6 10mg QQ客服:1413575084
    大黄酚-8-O-葡萄糖苷 CFN99410 13241-28-6 20mg QQ客服:1413575084
    大黄酚-8-O-葡萄糖苷 CFN99410 13241-28-6 50mg QQ客服:1413575084
    大黄酚-8-O-葡萄糖苷 CFN99410 13241-28-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Santa Catarina (Brazil)
  • Lodz University of Technology (Poland)
  • Sant Gadge Baba Amravati University (India)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Auckland (New Zealand)
  • University of Perugia (Italy)
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  • Ain Shams University (Egypt)
  • Chulalongkorn University (Thailand)
  • University of Fribourg (Switzerland)
  • Tokyo Woman's Christian University (Japan)
  • University of Hertfordshire (United Kingdom)
  • Chinese University of Hong Kong (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2021, 26(2):E255.
  • Sci Rep. 2017, 8207(7)
  • LWT2020, 126:109313
  • Drug Chem Toxicol.2020, 1-12.
  • Front Microbiol.2022, 12:833233.
  • Appl. Sci. 2021, 11(10),4666.
  • Phytother Res.2023, 37(10):4587-4606.
  • J Ethnopharmacol.2017, 198:91-97
  • Univerzita Karlova2022, 228192.
  • Food Chem.2022, 378:131975.
  • Am J Chin Med.2016, 44(8):1719-1735
  • J Cell Mol Med.2023, jcmm.18071.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • J Nat Prod.2015, 78(6):1339-4
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Tumour Biol.2015, 36(12):9385-93
  • Molecules.2016, 21(6)
  • Plants (Basel).2022, 11(21):2947.
  • Food Chem.2018, 252:207-214
  • Foods.2020, 9(10):1348.
  • Plants (Basel).2022, 11(16):2126.
  • Nutr Res Pract.2023, 17(4):670-681.
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • ...
  • 生物活性
    Description: Chrysophanol-8-O-beta-D-glucopyranoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway; it has potent inhibitory effect on collagen- and thrombin-induced platelet aggregation, it only inhibits platelet phosphatidylserine exposure.Chrysophanol-8-O-beta-D-glucopyranoside also exhibits significant anti-HBV activities with improved liver function, and enhanced HBeAg and HBsAg sero-conversion rates as well as HBV DNA clearance rates in HepG2 2.2.15 cells, DHBV models, or patients with chronic hepatitis B (CHB).
    Targets: HBV | GLUT
    In vitro:
    J Pharmacol Sci. 2012;118(2):245-54.
    Chrysophanol-8-O-glucoside, an anthraquinone derivative in rhubarb, has antiplatelet and anticoagulant activities.[Pubmed: 22302018]
    Rhubarb is a widely used traditional medicine and has been reported to elicit a number of biological effects including anti-inflammatory and antiplatelet effects. In the present study, we investigated the effects of anthraquinone derivatives isolated from rhubarb on platelet activity.
    METHODS AND RESULTS:
    Of four anthraquinone derivatives isolated from rhubarb examined, Chrysophanol 8-O-glucoside (CP-8-O-glc) was found to have the most potent inhibitory effect on collagen- and thrombin-induced platelet aggregation. Chrysophanol 8-O-glucoside-treated mice showed significantly prolonged bleeding times. Furthermore, Chrysophanol 8-O-glucoside was found to have a significant inhibitory effect on rat platelet aggregation ex vivo and on thromboxane A(2) formation in vitro. In coagulation tests, Chrysophanol 8-O-glucoside did not alter prothrombin time, and it prolonged the activated partial thromboplastin time. However, Chrysophanol 8-O-glucoside only inhibited platelet phosphatidylserine exposure, but not exert direct inhibition on intrinsic factors.
    CONCLUSIONS:
    This study demonstrates the antiplatelet and anticoagulant effects of Chrysophanol 8-O-glucoside and suggests that this compound might be of therapeutic benefit for the prevention of platelet-related cardiovascular diseases.
    Drug Discov Ther. 2013 Dec;7(6):212-24.
    Traditional Chinese medicine and related active compounds: a review of their role on hepatitis B virus infection.[Pubmed: 24423652]
    Over a long period of time in clinical practice and in basic research progress, the effectiveness and beneficial contribution of TCM on CHB have been gradually known and confirmed.
    METHODS AND RESULTS:
    Based upon our review of related papers and because of our prior knowledge and experience, we have selected some Chinese medicines, including Chinese herbal formulas (e.g., Xiao-Chai-Hu-Tang, Xiao-Yao-San, and Long-Dan-Xie-Gan-Tang), single herbs (e.g., Phyllanthus niruri, Radix astragali, Polygonum cuspidatum, Rheum palmatum, and Salvia miltiorrhiza) and related active compounds (e.g., wogonin, artesunate, saikosaponin, astragaloside IV, and chrysophanol 8-O-beta-Dglucoside(Chrysophanol 8-O-glucoside)) and Chinese medicine preparations (e.g., silymarin, silibinin, kushenin, and cinobufacini), which seem effective and worthy of additional and indepth study in treating CHB, and we have given them a brief review. We conclude that these Chinese herbal medicines exhibit significant anti-HBV activities with improved liver function, and enhanced HBeAg and HBsAg sero-conversion rates as well as HBV DNA clearance rates in HepG2 2.2.15 cells, DHBV models, or patients with CHB.
    CONCLUSIONS:
    We hope this review will contribute to an understanding of TCM and related active compounds as an effective treatment for CHB and provide useful information for the development of more effective antiviral drugs.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4015 mL 12.0077 mL 24.0154 mL 48.0307 mL 60.0384 mL
    5 mM 0.4803 mL 2.4015 mL 4.8031 mL 9.6061 mL 12.0077 mL
    10 mM 0.2402 mL 1.2008 mL 2.4015 mL 4.8031 mL 6.0038 mL
    50 mM 0.048 mL 0.2402 mL 0.4803 mL 0.9606 mL 1.2008 mL
    100 mM 0.024 mL 0.1201 mL 0.2402 mL 0.4803 mL 0.6004 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    葡欧鼠李苷 B; Glucofrangulin B CFN70247 14062-59-0 C26H28O14 = 564.5 5mg QQ客服:1413575084
    大黄素甲醚-1-O-β-D-葡萄糖苷; Physcion 1-O-beta-D-glucoside CFN91103 26296-54-8 C22H22O10 = 446.41 5mg QQ客服:1457312923
    芦西定 3-O-葡萄糖苷; Lucidin 3-O-glucoside CFN91032 22255-29-4 C21H20O10 = 432.38 5mg QQ客服:1413575084
    3-(beta-D-Glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione; 3-(beta-D-Glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione CFN91796 125906-49-2 C21H20O10 = 432.38 5mg QQ客服:1413575084
    1,3,6-三羟基-2-甲基蒽醌-3-O-新橙皮糖苷; 1,3,6-Trihydroxy-2-methylanthraquinone 3-O-alpha-L-rhamnosyl-(1->2)-beta-D-glucoside CFN95096 87686-88-2 C27H30O14 = 578.5 10mg QQ客服:1457312923
    檄树素苷; Morindin CFN70420 60450-21-7 C26H28O14 = 564.5 5mg QQ客服:3257982914
    大黄酸-8-葡萄糖苷钙盐; Rhein-8-glucoside calcium salt CFN99592 113443-70-2 C21H16O11.Ca = 484.43 5mg QQ客服:2056216494
    胭脂红; Carmine CFN90066 2611-82-7 C20H11N2O10S3 = 534.9 20mg QQ客服:1457312923
    芦荟素B; Aloin B CFN90434 28371-16-6 C21H22O9 = 418.39 20mg QQ客服:2159513211
    10-羟基芦荟苷B; 10-Hydroxyaloin B CFN95454 134863-92-6 C21H22O10 = 434.4 5mg QQ客服:2056216494

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