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  • 楤木皂苷A,竹节参皂苷IV

    Chikusetsusaponin IV

    楤木皂苷A,竹节参皂苷IV
    产品编号 CFN90542
    CAS编号 7518-22-1
    分子式 = 分子量 C47H74O18 = 927.08
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax japonicus C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    楤木皂苷A,竹节参皂苷IV CFN90542 7518-22-1 10mg QQ客服:3257982914
    楤木皂苷A,竹节参皂苷IV CFN90542 7518-22-1 20mg QQ客服:3257982914
    楤木皂苷A,竹节参皂苷IV CFN90542 7518-22-1 50mg QQ客服:3257982914
    楤木皂苷A,竹节参皂苷IV CFN90542 7518-22-1 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Agricultural Research Organization (ARO) (Israel)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Ain Shams University (Egypt)
  • Wroclaw Medical University (Poland)
  • Georgia Institute of Technology (USA)
  • University of Canterbury (New Zealand)
  • University of Melbourne (Australia)
  • Donald Danforth Plant Science Center (USA)
  • Tokyo Woman's Christian University (Japan)
  • Copenhagen University (Denmark)
  • Universidade Federal de Santa Catarina (Brazil)
  • Chinese University of Hong Kong (China)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Functional Foods2021, 84:104581
  • Nutraceutical Research . 2021, 19(1),p90-105.
  • Int J Med Sci.2021, 18(10):2155-2161.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Heliyon2020, 6(6):e04337.
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Saudi Pharmaceutical Journal2023, 31(12):101829
  • Oncotarget.2017, 8(64):108006-108019
  • Eur J Pharmacol.2018, 832:96-103
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • Nat Prod Commun.2018, 10.1177
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Molecules.2019, 24(19):E3417
  • Biomed Chromatogr.2020, e5021.
  • iScience.2020, 23(2):100849.
  • Industrial Crops and Products2017, 95:286-295
  • Exp Neurobiol.2018, 27(3):200-209
  • Natural Product Communications2020, doi: 10.1177.
  • Molecules2022, 27(9):2827.
  • Kor. J. Herbol.2019, 34(2):59-66
  • ...
  • 生物活性
    Description: Chikusetsusaponin IV may relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway.
    Targets: Fas/FasL
    In vitro:
    Planta Med. 2006 Feb;72(3):193-8.
    Suppression of Fas-mediated apoptosis of keratinocyte cells by chikusetsusaponins isolated from the roots of Panax japonicus.[Pubmed: 16534721]
    Activity-guided fractionation led to the isolation of Chikusetsusaponin IV, Chikusetsusaponin IVa, chikusetsusaponin V and polysciasaponin P5 as the active ingredients.
    METHODS AND RESULTS:
    Of these compounds, Chikusetsusaponin IV, was most active when applied at a concentration of 12.5 microg/mL. The intracellular hallmark events of apoptosis such as DNA fragmentation and chromatin condensation were significantly reduced by the treatment with Chikusetsusaponin IV. The apoptotic cell death of Jurkat cells was also suppressed by treatment with the active saponins.
    CONCLUSIONS:
    These results suggest that the use of Chikusetsusaponin IV, Chikusetsusaponin IVa, chikusetsusaponin V, polysciasaponin P5, or a crude extract of P. japonicus containing these saponins is expected to relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway.
    Biomed Res . 2010 Apr;31(2):155-9.
    Inhibition of human renin activity by saponins[Pubmed: 20460744]
    Abstract Renin is the most important enzyme in the renin-angiotensin system. Our previous study led to the identification of soyasaponin I, the first renin inhibitor isolated from soybean. In the present study, the effects of saponins and sapogenols on human renin activities were investigated. Soyasaponins I and II, glycyrrhizin, monoglucuronyl glycyrrhetic acid (MGGA), chikusetsusaponin IV, and Kochia scoparia fruit saponins (momordins) were found to inhibit renin activity. On the other hand, sapogenols (soyasapogenol B and glycyrrhetic acid), saikosaponins b2 and c, and ginsenoside Rb(1) had no effect on renin activity. These results clearly indicate that the 3-O-beta-dglucopyranosiduronic moiety in saponins (glucuronide saponin) is essential for renin inhibition.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0787 mL 5.3933 mL 10.7866 mL 21.5731 mL 26.9664 mL
    5 mM 0.2157 mL 1.0787 mL 2.1573 mL 4.3146 mL 5.3933 mL
    10 mM 0.1079 mL 0.5393 mL 1.0787 mL 2.1573 mL 2.6966 mL
    50 mM 0.0216 mL 0.1079 mL 0.2157 mL 0.4315 mL 0.5393 mL
    100 mM 0.0108 mL 0.0539 mL 0.1079 mL 0.2157 mL 0.2697 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    川牛膝皂苷B; Cyaonoside B CFN91695 51161-58-1 C48H76O18 = 941.1 10mg QQ客服:1457312923
    川牛膝皂苷A; Cyaonoside A CFN91696 110081-91-9 C54H86O23 = 1103.3 10mg QQ客服:2056216494
    龙牙楤木皂甙VII; Tarasaponin VII CFN90543 144118-18-3 C52H84O21 = 1045.22 5mg QQ客服:1457312923
    辽东楤木皂苷V; Araloside V CFN90322 340963-86-2 C54H88O23 = 1105.3 20mg QQ客服:1457312923
    辽东楤木皂苷X; Araloside X CFN90323 344911-90-6 C60H98O28 = 1267.42 20mg QQ客服:1457312923
    日本续断皂甙E1; Japondipsaponin E1 CFN95354 175586-66-0 C59H96O26 = 1221.4 5mg QQ客服:2159513211
    常春藤皂苷B; Hederasaponin B CFN99986 36284-77-2 C59H96O25 = 1205.4 20mg QQ客服:2056216494
    Acanthopanaxoside B; Acanthopanaxoside B CFN93301 915792-03-9 C61H98O27 = 1263.43 5mg QQ客服:1413575084
    红背银莲花皂甙R8; Raddeanoside R8 CFN94832 124961-61-1 C65H106O30 = 1367.54 20mg QQ客服:1457312923
    两头尖皂苷R9; Raddeanoside R9 CFN95636 124961-62-2 C65H106O31 = 1383.6 5mg QQ客服:215959384

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