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  • 刺苞菊甙

    Carlinoside

    刺苞菊甙
    产品编号 CFN90720
    CAS编号 59952-97-5
    分子式 = 分子量 C26H28O15 = 580.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Lespedeza bicolor Turcz.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    刺苞菊甙 CFN90720 59952-97-5 1mg QQ客服:215959384
    刺苞菊甙 CFN90720 59952-97-5 5mg QQ客服:215959384
    刺苞菊甙 CFN90720 59952-97-5 10mg QQ客服:215959384
    刺苞菊甙 CFN90720 59952-97-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2021, 26(18):5665.
  • J Adv Res.2019, 17:85-94
  • PLoS One.2021, 16(9):e0257243.
  • Molecules 2021, 26(4),1092.
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  • Tissue Cell.2022, 78:101901.
  • Biochem Biophys Res Commun.2018, 505(1):261-266
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  • Appl. Sci. 2021, 11(17),7829
  • US20170000760 A12016, 42740
  • J Ethnopharmacol.2017, 198:87-90
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  • Universidade Estadual Paulista2017, 42785
  • Front Pharmacol.2021, 12:690113.
  • Plant Pathology2022, 10.1111:ppa.13651.
  • Life Sci.2022, 311(Pt A):121157.
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  • ...
  • 生物活性
    Description: Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclear translocation and stimulates UGT1A1 promoter activity.
    Targets: Nrf2
    In vitro:
    Environ Res . 2018 Feb;161:512-523.
    Impact of edaphic factors and nutrient management on the hepatoprotective efficiency of Carlinoside purified from pigeon pea leaves: An evaluation of UGT1A1 activity in hepatitis induced organelles[Pubmed: 29223776]
    Abstract Carlinoside is a unique compound well-known for its excellent curative potential in hepatitis. There is a substantial research gap regarding the medicinal use of carlinoside, as its concentrations are greatly variable (depending on locality). We cultivated Cajanus cajan using vermicompost as a major organic amendment at two locations (Sonitpur and Birbhum) with different soil types, but identical climate conditions. Sonitpur soils were richer in soil organic C (SOC), enzyme activation, and N/P content than Birbhum. However, vermi-treatment improved many soil properties (bulk density, water retention, pH, N/P/K, and enzyme activity) to narrow the locational gap in soil quality by 15-28%. We also recorded a many-fold increment in SOC storage capacities in both locations, which was significantly correlated with carlinoside, total phenol, and flavonoid contents in Cajanus leaves. This significantly up-regulated the carlinoside induced expression of the bilirubin-solubilizing UGT1A1enzyme in HepG2 cell and rat liver. Leaf extracts of vermicompost-aided plants could cure hepatitis in affected rat livers and in the HepG2 cell line. Accordingly, vermi-treatment is an effective route for the growth of Cajanus as a cash crop for biomedical applications and can produce a concurrent improvement in soil quality. Keywords: Bilirubin solubilization; Cajanus cajan; Carlinoside; Organic fertilization; UGT1A1 expression.
    In vivo:
    Biochem Pharmacol. 2011 Nov 1;82(9):1186-97.
    Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression.[Pubmed: 21801714 ]
    Accumulation of bilirubin, primarily because of its insolubility, has been found to be associated with liver diseases including jaundice. Free bilirubin is insoluble; its glucuronidation by bilirubin-UGT enzyme (UGT1A1) makes it soluble and eliminates it through urine and faeces.
    METHODS AND RESULTS:
    Taking CCl(4) induced rat liver dysfunction model, we demonstrated that suppression of UGT1A1 activity in rat liver increased serum bilirubin level which could be reversed by carlinoside (Cln), a flavone glycoside. Although Cln is a flavone compound, it escaped self-glucuronidation in the intestine and readily absorbed. Kinetic study of microsomal UGT1A1 from HepG2 cells suggested that Cln enhanced enzyme activity by increasing V(max) without altering K(m). This altered V(max) was found to be due to UGT1A1 overexpression by Cln which was observed in both HepG2 and rat primary hepatocytes. Since Nrf2 is the transcription factor of UGT1A1, we examined whether Cln effect on UGT1A1 overexpression is mediated through Nrf2. In Nrf2 knock-out cells, Cln could not elevate UGT1A1 activity indicating Nrf2 to be its target. Cln significantly increased Nrf2 gene expression in HepG2 cells which was subsequently localized in nuclear region. Results from ChIP assay showed that Cln markedly augmented Nrf2 binding to UGT1A1 promoter that consequently enhanced reporter activity.
    CONCLUSIONS:
    Our findings therefore show that Cln upregulated Nrf2 gene expression, increased its nuclear translocation and stimulated UGT1A1 promoter activity. Total outcome of these events brought about a significant increase of bilirubin glucuronidation. Cln therefore could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7227 mL 8.6133 mL 17.2265 mL 34.4531 mL 43.0663 mL
    5 mM 0.3445 mL 1.7227 mL 3.4453 mL 6.8906 mL 8.6133 mL
    10 mM 0.1723 mL 0.8613 mL 1.7227 mL 3.4453 mL 4.3066 mL
    50 mM 0.0345 mL 0.1723 mL 0.3445 mL 0.6891 mL 0.8613 mL
    100 mM 0.0172 mL 0.0861 mL 0.1723 mL 0.3445 mL 0.4307 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异金雀花素; Isoscoparin CFN90965 20013-23-4 C22H22O11 = 462.40 10mg QQ客服:3257982914
    异金雀花素-2''-Beta-D-吡喃葡萄糖苷; Isoscoparin-2''-Beta-D-glucopyranoside CFN90900 97605-25-9 C28H32O16 = 624.54 5mg QQ客服:1413575084
    4'-O-甲基光牡荆素II; 4'-O-Methyllucenin II (Diosmetin 6,8-di-C-glucoside) CFN95344 98813-28-6 C28H32O16 = 624.6 10mg QQ客服:2159513211
    白杨素 6-C-葡萄糖 8-C-阿拉伯糖苷; Chrysin 6-C-glucoside 8-C-arabinoside CFN92285 185145-34-0 C26H28O13 = 548.5 5mg QQ客服:2056216494
    白杨素 8-C-葡萄糖苷; Chrysin 8-C-glucoside CFN91992 160880-89-7 C21H20O9 = 416.38 5mg QQ客服:2159513211
    白杨素 6-C-阿拉伯糖 8-C-葡萄糖苷; Chrysin 6-C-arabinoside 8-C-glucoside CFN92284 185145-33-9 C26H28O13 = 548.5 5mg QQ客服:3257982914
    异荭草苷; 异荭草素; Luteolin-6-C-glucoside CFN98137 4261-42-1 C21H20O11 = 448.38 20mg QQ客服:1457312923
    日当药黄素,日本当药黄素,日本獐牙菜素; Swertiajaponin CFN90652 6980-25-2 C22H22O11 = 462.4 10mg QQ客服:215959384
    荭草苷; Orientin CFN98136 28608-75-5 C21H20O11 = 448.38 20mg QQ客服:1457312923
    2''-O-p-反式香豆酰基荭草苷; Orientin 2''-O-p-trans-coumarate CFN90653 73815-15-3 C30H26O13 = 594.5 5mg QQ客服:215959384

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