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  • 大麻二酚

    Cannabidiol

    大麻二酚
    产品编号 CFN99444
    CAS编号 13956-29-1
    分子式 = 分子量 C21H30O2 = 314.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Cannabis sativa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大麻二酚 CFN99444 13956-29-1 10mg QQ客服:2056216494
    大麻二酚 CFN99444 13956-29-1 20mg QQ客服:2056216494
    大麻二酚 CFN99444 13956-29-1 50mg QQ客服:2056216494
    大麻二酚 CFN99444 13956-29-1 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Toulouse (France)
  • University of Oslo (Norway)
  • Tohoku University (Japan)
  • University of Minnesota (USA)
  • Agricultural Research Organization (ARO) (Israel)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Brasilia (Brazil)
  • University of Vigo (Spain)
  • Monash University Sunway Campus (Malaysia)
  • Kyoto University (Japan)
  • University of Hertfordshire (United Kingdom)
  • University of British Columbia (Canada)
  • University of Indonesia (Indonesia)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomed Pharmacother.2022, 145:112410.
  • Phytochemistry Letters2017, 449-455
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Braz J Med Biol Res. 2016, 49(7)
  • Appl. Sci.2023, 13(17), 9653.
  • J Sep Sci.2018, 41(11):2488-2497
  • Nat Commun.2019, 10(1):5169
  • bioRxiv - Biochemistry2023, 548213.
  • Appl. Sci.2020, 10(23), 8729
  • Sci Rep.2018, 8:15059
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Horticulturae2021, 7(1),5.
  • J Chromatogr Sci.2015, 53(5):824-9
  • Food Bioscience2023, 56:103311.
  • Sci Rep.2023, 13(1):14594.
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • J Food Biochem.2019, 43(9):e12970
  • Nat Prod Commun.2018, 10.1177
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Molecules.2022, 27(13):4227.
  • Neurochem Res.2021, s11064-021-03449-0
  • Virus Res.2023, 335:199199.
  • ...
  • 生物活性
    Description: Cannabidiol has a potent anti-arthritic effect in collagen-induced arthritis through its combined immunosuppressive and anti-inflammatory actions, it has a pharmacological profile similar to that of atypical antipsychotic drugs. Cannabidiol exerts a combination of neuroprotective, anti-oxidative and anti-apoptotic effects against beta-amyloid peptide toxicity, and that inhibition of caspase 3 appearance from its inactive precursor, pro-caspase 3, by cannabidiol is involved in the signalling pathway for this neuroprotection. Cannabidiol may have great therapeutic potential in the treatment of diabetic complications, and perhaps other cardiovascular disorders, by attenuating oxidative/ nitrative stress, inflammation, cell death and fibrosis.
    Targets: JNK | MAPK | P450 (e.g. CYP17) | TNF-α | COX | NF-kB | Caspase | 5-HT Receptor
    In vivo:
    Epilepsy Behav. 2013 Dec;29(3):574-7.
    Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.[Pubmed: 24237632]
    Severe childhood epilepsies are characterized by frequent seizures, neurodevelopmental delays, and impaired quality of life. In these treatment-resistant epilepsies, families often seek alternative treatments. This survey explored the use of Cannabidiol-enriched cannabis in children with treatment-resistant epilepsy.
    METHODS AND RESULTS:
    The survey was presented to parents belonging to a Facebook group dedicated to sharing information about the use of Cannabidiol-enriched cannabis to treat their child's seizures. Nineteen responses met the following inclusion criteria for the study: a diagnosis of epilepsy and current use of Cannabidiol-enriched cannabis. Thirteen children had Dravet syndrome, four had Doose syndrome, and one each had Lennox-Gastaut syndrome and idiopathic epilepsy. The average number of antiepileptic drugs (AEDs) tried before using Cannabidiol-enriched cannabis was 12. Sixteen (84%) of the 19 parents reported a reduction in their child's seizure frequency while taking Cannabidiol-enriched cannabis. Of these, two (11%) reported complete seizure freedom, eight (42%) reported a greater than 80% reduction in seizure frequency, and six (32%) reported a 25-60% seizure reduction. Other beneficial effects included increased alertness, better mood, and improved sleep. Side effects included drowsiness and fatigue. Our survey shows that parents are using Cannabidiol-enriched cannabis as a treatment for their children with treatment-resistant epilepsy. Because of the increasing number of states that allow access to medical cannabis, its use will likely be a growing concern for the epilepsy community. Safety and tolerability data for Cannabidiol-enriched cannabis use among children are not available.
    CONCLUSIONS:
    Objective measurements of a standardized preparation of pure Cannabidiol are needed to determine whether it is safe, well tolerated, and efficacious at controlling seizures in this pediatric population with difficult-to-treat seizures.
    J Trace Elem Med Biol. 2013 Oct;27(4):355-63.
    Protective effect of cannabidiol against cadmium hepatotoxicity in rats.[Pubmed: 23993482]

    METHODS AND RESULTS:
    The protective effect of cannabidiol, the non-psychoactive component of Cannabis sativa, against liver toxicity induced by a single dose of cadmium chloride (6.5 mgkg(-1) i.p.) was investigated in rats. Cannabidiol treatment (5 mgkg(-1)/day, i.p.) was applied for five days starting three days before cadmium administration. Cannabidiol significantly reduced serum alanine aminotransferase, and suppressed hepatic lipid peroxidation, prevented the depletion of reduced glutathione and nitric oxide, and catalase activity, and attenuated the elevation of cadmium level in the liver tissue resulted from cadmium administration. Histopathological examination showed that cadmium-induced liver tissue injury was ameliorated by cannabidiol treatment. Immunohistochemical analysis revealed that cannabidiol significantly decreased the cadmium-induced expression of tumor necrosis factor-α, cyclooxygenase-2, nuclear factor-κB, caspase-3, and caspase-9, and increased the expression of endothelial nitric oxide synthase in liver tissue.
    CONCLUSIONS:
    It was concluded that cannabidiol may represent a potential option to protect the liver tissue from the detrimental effects of cadmium toxicity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1797 mL 15.8983 mL 31.7965 mL 63.593 mL 79.4913 mL
    5 mM 0.6359 mL 3.1797 mL 6.3593 mL 12.7186 mL 15.8983 mL
    10 mM 0.318 mL 1.5898 mL 3.1797 mL 6.3593 mL 7.9491 mL
    50 mM 0.0636 mL 0.318 mL 0.6359 mL 1.2719 mL 1.5898 mL
    100 mM 0.0318 mL 0.159 mL 0.318 mL 0.6359 mL 0.7949 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-羟基-5-戊基苯基-beta-D-吡喃葡萄糖甙; 11-Dehydroxygrevilloside B CFN98002 197307-49-6 C17H26O7 = 342.4 5mg QQ客服:3257982914
    4-(3,4-二羟基苯基)-2-丁酮; 4-(3,4-Dihydroxyphenyl)-2-butanone CFN97044 61152-62-3 C10H12O3 = 180.2 5mg QQ客服:3257982914
    4-(3,4-二甲氧基苯基)-3-丁烯-1-醇; 4-(3,4-Dimethoxyphenyl)-3-buten-1-ol CFN97183 69768-97-4 C12H16O3 = 208.3 5mg QQ客服:3257982914
    4-(3,4-二甲氧基苯基)-3-丁烯-1,2-二醇; 4-(3,4-Dimethoxyphenyl)-3-butene-1,2-diol CFN99692 164661-12-5 C12H16O4 = 224.3 5mg QQ客服:2159513211
    Turmeronol A; Turmeronol A CFN96471 131651-37-1 C15H20O2 = 232.32 5mg QQ客服:2159513211
    大麻二酚; Cannabidiol CFN99444 13956-29-1 C21H30O2 = 314.5 20mg QQ客服:215959384
    大麻二酚羟基醌; Cannabidiol hydroxyquinone CFN91619 137252-25-6 C21H28O3 = 328.45 5mg QQ客服:2159513211
    表大麻二醇水合物; Epicannabidiol hydrate CFN99443 139561-95-8 C21H32O3 = 332.5 5mg QQ客服:2056216494
    大麻二醇酸; Cannabidiolic acid CFN99356 1244-58-2 C22H30O4 = 358.5 5mg QQ客服:2056216494
    Delta-9-四氢大麻酚酸; Delta-9-Tetrahydrocannabinolic acid CFN91872 23978-85-0 C22H30O4 = 358.47 5mg QQ客服:1413575084

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