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  • 咖啡酸苯乙酯

    Caffeic acid phenethyl ester

    咖啡酸苯乙酯
    产品编号 CFN90554
    CAS编号 104594-70-9
    分子式 = 分子量 C17H16O4 = 284.31
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The barks of Cinnamomum cassia Presl
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    咖啡酸苯乙酯 CFN90554 104594-70-9 10mg QQ客服:2056216494
    咖啡酸苯乙酯 CFN90554 104594-70-9 20mg QQ客服:2056216494
    咖啡酸苯乙酯 CFN90554 104594-70-9 50mg QQ客服:2056216494
    咖啡酸苯乙酯 CFN90554 104594-70-9 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Goias (UFG) (Brazil)
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  • University of Canterbury (New Zealand)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Industrial Crops and Products2020, 146:112186
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Fitoterapia.2015, 100:179-86
  • Cancers (Basel).2023, 15(1):293.
  • Virulence.2018, 9(1):588-603
  • Planta Med.2016, 82(13):1208-16
  • Kangwon National University2022, 37(1):29-37
  • Sustainability2021, 13(23),12981.
  • Nutrients.2020, 12(3):595.
  • J. of Med. Plant Research.2013, 90-151
  • Foods.2021, 10(11):2754.
  • Int J Pharm.2022, 618:121636.
  • J.Food Processing & Preservation2022, jfpp.16666
  • J Chromatogr B Analyt Technol Biomed Life Sci.2021, 1187:123012.
  • Toxicol Mech Methods.2021, 1-12.
  • Biomed Pharmacother.2021, 137:111362.
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • J Nat Prod.2018, 81(4):966-975
  • Antibiotics.2022, 11(4), 510.
  • Nutrients.2017, 10(1)
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • Mutlu Yanic S, Ates EG. JOTCSA.2023, 10(4);893-902.
  • PLoS One.2018, 13(4):e0195642
  • ...
  • 生物活性
    Description: Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays neuroprotective, antioxidant, immunomodulatory and antiinflammatory activities; it also has potential beneficial effects on the wound healing of nasal mucosa in the rat.Caffeic acid phenethyl ester has potential preventive effects on myringosclerosis development after myringotomy and ventilation tube insertion.
    Targets: NF-κB | IL Receptor | MCP-1 | ICAM-1 | Akt
    In vitro:
    Immunopharmacol Immunotoxicol. 2014 Oct;36(5):371-7.
    Caffeic acid phenethyl ester inhibits the inflammatory effects of interleukin-1β in human corneal fibroblasts.[Pubmed: 25151996]
    The regulatory mechanisms of Caffeic acid phenethyl ester on cellular signaling pathways were examined using Western blot and electrophoretic mobility shift assays.
    METHODS AND RESULTS:
    A functional validation was carried out by evaluating the inhibitory effects of Caffeic acid phenethyl ester on neutrophil and monocyte migration in vitro. Caffeic acid phenethyl ester inhibited the expression of IL-6, MCP-1 and ICAM-1 induced by the pro-inflammatory cytokine IL-1β in corneal fibroblasts. The activation of AKT and NF-κB by IL-1β was markedly inhibited by Caffeic acid phenethyl ester, whereas the activity of mitogen-activated protein kinases (MAPKs) was not affected. Caffeic acid phenethyl ester significantly suppressed the IL-1β-induced migration of differentiated (d)HL-60 and THP-1 cells.
    CONCLUSIONS:
    These anti-inflammatory effects of Caffeic acid phenethyl ester may be expected to inhibit the infiltration of leukocytes into the corneal stroma in vivo.
    Oncotarget . 2015 Mar 30;6(9):6684-707.
    Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1[Pubmed: 25788262]
    Abstract Prostate cancer (PCa) patients receiving the androgen ablation therapy ultimately develop recurrent castration-resistant prostate cancer (CRPC) within 1-3 years. Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell cycle arrest in LNCaP 104-R1, DU-145, 22Rv1, and C4-2 CRPC cells. CAPE treatment also inhibited soft agar colony formation and retarded nude mice xenograft growth of LNCaP 104-R1 cells. We identified that CAPE treatment significantly reduced protein abundance of Skp2, Cdk2, Cdk4, Cdk7, Rb, phospho-Rb S807/811, cyclin A, cyclin D1, cyclin H, E2F1, c-Myc, SGK, phospho-p70S6kinase T421/S424, phospho-mTOR Ser2481, phospho-GSK3α Ser21, but induced p21Cip1, p27Kip1, ATF4, cyclin E, p53, TRIB3, phospho-p53 (Ser6, Ser33, Ser46, Ser392), phospho-p38 MAPK Thr180/Tyr182, Chk1, Chk2, phospho-ATM S1981, phospho-ATR S428, and phospho-p90RSK Ser380. CAPE treatment decreased Skp2 and Akt1 protein expression in LNCaP 104-R1 tumors as compared to control group. Overexpression of Skp2, or siRNA knockdown of p21Cip1, p27Kip1, or p53 blocked suppressive effect of CAPE treatment. Co-treatment of CAPE with PI3K inhibitor LY294002 or Bcl-2 inhibitor ABT737 showed synergistic suppressive effects. Our finding suggested that CAPE treatment induced cell cycle arrest and growth inhibition in CRPC cells via regulation of Skp2, p53, p21Cip1, and p27Kip1. Keywords: Skp2; caffeic acid phenethyl ester; cell cycle arrest; p53; prostate cancer.
    In vivo:
    Am J Otolaryngol. 2014 Jul-Aug;35(4):482-6.
    Effects of caffeic acid phenethyl ester on wound healing of nasal mucosa in the rat: an experimental study.[Pubmed: 24767474]
    In this experimental study, our aim was to use histopathological examination to investigate the effects of Caffeic acid phenethyl ester on the wound healing of rat nasal mucosa after mechanical trauma.
    METHODS AND RESULTS:
    The rats were randomly divided into 3 experimental groups: a non-treated group (n=7), a control saline group (n=7) and a Caffeic acid phenethyl ester group (n=7). The non-treated group received no treatment for 15 days. The second group was administered saline (2.5 mL/kg, intraperitoneal) once a day for 15 days. The third group received Caffeic acid phenethyl ester intraperitoneally at a dose of 10 μmol/kg once a day for 15 days. At the beginning of the study, unilateral mechanical nasal trauma was induced on the right nasal mucosa of all rats in the three groups using a brushing technique. Samples were stained using hematoxylin and eosin solution and were examined by a pathologist using a light microscope. The severity of inflammation was milder in the Caffeic acid phenethyl ester group compared with that in the non-treated and saline groups (P<0.05). The subepithelial thickness index was lower in the experimental group (P<0.05). Goblet cell and ciliated cell loss was substantially reduced in the experimental group compared with the non-treated and saline groups (P<0.05).
    CONCLUSIONS:
    Caffeic acid phenethyl ester decreases inflammation and the loss of goblet cells and ciliated cells. Therefore, Caffeic acid phenethyl ester has potential beneficial effects on the wound healing of nasal mucosa in the rat.
    Epilepsy Behav. 2013 Nov;29(2):275-80.
    Caffeic acid phenethyl ester prevents apoptotic cell death in the developing rat brain after pentylenetetrazole-induced status epilepticus.[Pubmed: 24012504]
    The aim of this study was to investigate whether Caffeic acid phenethyl ester exerts neuroprotective effects on the developing rat brain after status epilepticus.
    METHODS AND RESULTS:
    Twenty-one dams reared Wistar male rats, and 21-day-old rats were divided into three groups: control group, pentylenetetrazole-induced status epilepticus group, and Caffeic acid phenethyl ester-treated group. Status epilepticus was induced on the first day of experiment. Caffeic acid phenethyl ester injections (30 mg/kg intraperitoneally) started 40 min after the tonic phase of status epilepticus was reached, and the injections of Caffeic acid phenethyl ester were repeated over 5 days. Rats were sacrificed, and brain tissues were collected on the 5th day of experiment after the last injection of Caffeic acid phenethyl ester. Apoptotic cell death was evaluated. Histopathological examination showed that Caffeic acid phenethyl ester significantly preserved the number of neurons in the CA1, CA3, and dentate gyrus regions of the hippocampus and the prefrontal cortex. It also diminished apoptosis in the hippocampus and the prefrontal cortex.
    CONCLUSIONS:
    In conclusion, this experimental study suggests that Caffeic acid phenethyl ester administration may be neuroprotective in status epilepticus in the developing rat brain.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5173 mL 17.5864 mL 35.1729 mL 70.3457 mL 87.9322 mL
    5 mM 0.7035 mL 3.5173 mL 7.0346 mL 14.0691 mL 17.5864 mL
    10 mM 0.3517 mL 1.7586 mL 3.5173 mL 7.0346 mL 8.7932 mL
    50 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.4069 mL 1.7586 mL
    100 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.7035 mL 0.8793 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    丹参素; Danshensu CFN99539 22681-72-7 C9H10O5 = 198.17 20mg QQ客服:3257982914
    丹参素钠; Sodium Danshensu CFN99163 67920-52-9 C9H9O5Na = 220.2 20mg QQ客服:1457312923
    左旋多巴; Levodopa CFN99800 59-92-7 C9H11NO4 = 197.20 20mg QQ客服:1457312923
    Trans-咖啡酸; Trans-caffeic acid CFN92549 501-16-6 C9H8O4 = 180.2 20mg QQ客服:2159513211
    咖啡酸甲酯; Methyl caffeate acid CFN95561 3843-74-1 C10H10O4 = 194.18 5mg QQ客服:3257982914
    咖啡酸乙酯; Ethyl caffeate CFN97136 66648-50-8 C11H12O4 = 208.2 20mg QQ客服:3257982914
    咖啡酸苯乙酯; Caffeic acid phenethyl ester CFN90554 104594-70-9 C17H16O4 = 284.31 20mg QQ客服:3257982914
    Nepetoidin B; Nepetoidin B CFN96779 55486-06-1 C17H14O6 = 314.29 5mg QQ客服:1413575084
    Cinnamyl caffeate; Cinnamyl caffeate CFN89444 115610-32-7 C18H16O4 = 296.31 5mg QQ客服:1413575084
    香豆酸肉桂酯; Cinnamyl coumarate CFN89462 115610-30-5 C18H16O3 = 280.31 5mg QQ客服:3257982914

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