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  • Cabralealactone

    Cabralealactone

    Cabralealactone
    产品编号 CFN98005
    CAS编号 19865-87-3
    分子式 = 分子量 C27H42O3 = 414.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Aglaia lawii
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Cabralealactone CFN98005 19865-87-3 1mg QQ客服:3257982914
    Cabralealactone CFN98005 19865-87-3 5mg QQ客服:3257982914
    Cabralealactone CFN98005 19865-87-3 10mg QQ客服:3257982914
    Cabralealactone CFN98005 19865-87-3 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medical University of South Carolina (USA)
  • Seoul National University (Korea)
  • Ateneo de Manila University (Philippines)
  • University of Illinois at Chicago (USA)
  • Heidelberg University (Germany)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Anna University (India)
  • Georgia Institute of Technology (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Korea Food Research Institute(KFRI) (Korea)
  • Utrecht University (Netherlands)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Microchemical Journal2018, 137:168-173
  • FASEB J.2022, 36(7):e22387.
  • Biomolecules.2019, 9(11):E696
  • TCI CO.2019, US20190151257A1
  • Phytomedicine.2019, 67:153159
  • J Ethnopharmacol.2021, 267:113615.
  • Acta Chromatographica2016, 29(3)
  • Plant J.2017, 90(3):535-546
  • Evid Based Complement Alternat Med.2021, 2021:6687513.
  • International Food Research Journal2018, 25(6):2560-2571
  • Phytomedicine.2022, 102:154183.
  • Metab Eng.2022, 75:143-152.
  • Drug Dev Res.2022, 83(7):1673-1682.
  • Molecules.2018, 23(7):E1659
  • Vojnosanit Pregl2016, 75(00):391-391
  • Microchemical Journal2024: 196:109676.
  • Nutrients.2019, 11(11):E2694
  • bioRxiv - Molecular Biology2023, 535548.
  • J Biomed Sci.2020, 27(1):60.
  • Int J Mol Sci.2023, 24(8):7442.
  • Mutlu Yanic S, Ates EG. JOTCSA.2023, 10(4);893-902.
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • J-STAGE2015, 249-255
  • ...
  • 生物活性
    Description: Cabralealactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line, it is moderately active against a small-cell lung cancer (NCI-H187) cell line.
    Targets: Antifection
    In vitro:
    Nat Prod Res. 2011 Oct;25(17):1621-8.
    Biologically active constituents of Aglaia erythrosperma.[Pubmed: 22011221]

    METHODS AND RESULTS:
    From the fruits and leaves of Aglaia erythrosperma (Meliaceae), 10 chemical constituents were isolated and identified, i.e. the dammarane triterpenoids cabraleadiol (1), cabraleahydroxylactone (2), ethyl eichlerianoate (3), eichlerialactone (4), aglinin A (5), Cabralealactone (6), the aglaialactone 5,6-desmethylenedioxy-5-methoxy-aglalactone (7), the flavagline 4'-demethoxy-3',4'-methylenedioxy-methyl rocaglate (8) and two coumarins: scoparone and scopoletin.
    CONCLUSIONS:
    Flavagline 8 exhibited antimalarial activity with an IC(50) value of 7.30 µg mL(-1) and was strongly cytotoxic against small cell lung cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines, with IC(50) values of 2.17, 2.10 and 0.11 µg mL(-1), respectively. Aglinin A (5) displayed moderate cytotoxicity against all the three cancer cell lines, whereas ethyl eichlerianoate (3), Cabralealactone (6) and the aglaialactone 7 were exclusively cytotoxic to NCI-H187 cell line. Cabraleahydroxylactone (2) showed antiviral activity against herpes simplex virus type-1 with an IC(50) value of 3.20 µg mL(-1), in comparison with the standard acyclovir (IC(50) = 1.90 µg mL(-1)). When tested for antimycobacterial activity against Mycobacterium tuberculosis H(37)Ra, compounds 1-4 and 6-8 displayed minimum inhibitory concentration in the range of 25-50 µg mL(-1).
    Arch Pharm Res. 2008 Jan;31(1):21-7.
    A new sesquiterpene and other terpenoid constituents of Chisocheton penduliflorus.[Pubmed: 18277603]

    METHODS AND RESULTS:
    A new aromadendrane sesquiterpene, allo-aromadendrane-10alpha, 14-diol (3), was isolated from Chisocheton penduliflorus (Meliaceae), along with two known sesquiterpenes: allo-aromadendrane-10beta, 14-diol (2) and allo-aromadendrane-10beta, 13, 14-triol (7). Six dammarane triterpenoids, including cabraleadiol (1), eichlerialactone (4), cabraleahydroxylactone (5), Cabralealactone (6), hollongdione (8) and dammaradienone (9), the coumarins scoparone and scopoletin, and vanillic acid were also isolated from the wood and leaves of this plant.
    CONCLUSIONS:
    Compounds 1-7 displayed antimycobacterial activity against Mycobacterium tuberculosis. Compounds 1, 4, 5 and 6 were weakly cytotoxic to a breast cancer (BC) cell line; whereas, compound 6 was moderately active against a small-cell lung cancer (NCI-H187) cell line.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.412 mL 12.0598 mL 24.1196 mL 48.2393 mL 60.2991 mL
    5 mM 0.4824 mL 2.412 mL 4.8239 mL 9.6479 mL 12.0598 mL
    10 mM 0.2412 mL 1.206 mL 2.412 mL 4.8239 mL 6.0299 mL
    50 mM 0.0482 mL 0.2412 mL 0.4824 mL 0.9648 mL 1.206 mL
    100 mM 0.0241 mL 0.1206 mL 0.2412 mL 0.4824 mL 0.603 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-表南美楝羟基内酯; 3-Epicabraleahydroxylactone CFN98482 35833-72-8 C27H44O3 = 416.6 5mg QQ客服:3257982914
    南美楝羟基促皮质素; Cabraleahydroxylactone CFN98480 35833-69-3 C27H44O3 = 416.6 5mg QQ客服:3257982914
    南美楝羟基促皮质素醋酸酯; Cabraleahydroxylactone acetate CFN98481 35833-70-6 C29H46O4 = 458.7 5mg QQ客服:1413575084
    Cabralealactone; Cabralealactone CFN98005 19865-87-3 C27H42O3 = 414.6 5mg QQ客服:2159513211
    艾希勒螺内酯; Eichlerialactone CFN98092 2202-01-9 C27H42O4 = 430.6 5mg QQ客服:3257982914

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