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  • 鸦胆醇

    Bruceantinol

    鸦胆醇
    产品编号 CFN89336
    CAS编号 53729-52-5
    分子式 = 分子量 C30H38O13 = 606.62
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The fruits of Brucea javanica (L.) Merr.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸦胆醇 CFN89336 53729-52-5 1mg QQ客服:2056216494
    鸦胆醇 CFN89336 53729-52-5 5mg QQ客服:2056216494
    鸦胆醇 CFN89336 53729-52-5 10mg QQ客服:2056216494
    鸦胆醇 CFN89336 53729-52-5 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Indonesia (Indonesia)
  • Indian Institute of Science (India)
  • Ateneo de Manila University (Philippines)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Wuerzburg (Germany)
  • Melbourne University (Australia)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Mysore (India)
  • Universidade de Franca (Brazil)
  • University of Hertfordshire (United Kingdom)
  • University of Wisconsin-Madison (USA)
  • Srinakharinwirot University (Thailand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Sci Food Agric.2023, 103(1):213-220.
  • PLoS One.2020, 15(2):e0220084.
  • JAOCS2021, 98(7):779-794.
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • Phytomedicine.2022, 102:154183.
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Cosmetics2021, 8(3),91.
  • Sci Rep.2023, 13(1):13610.
  • PLoS One.2015, 10(5):e0127060
  • Oncol Lett.2020, 20(4):122.
  • J. Food Composition and Analysis2022, 114:104731
  • Int J Mol Sci.2019, 20(21):E5488
  • Front Cell Dev Biol.2021, 9:764263.
  • J Nat Med.2017, 71(4):745-756
  • Oncol Rep.2021, 46(2):166.
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Applied Biological Chemistry2022, 65(77).
  • J Agric Food Chem.2020, 68(51):15164-15175
  • Biomed Pharmacother.2021, 137:111362.
  • Antioxidants (Basel).2022, 11(8):1471.
  • J Asian Nat Prod Res.2019, 5:1-17
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • ...
  • 生物活性
    Description: Bruceantinol has antiviral activity, it can inhibit pepper mottle virus in pepper; it shows antibabesial activity against Babesia gibsoni in vitro, with the IC50 value of 12 ng/mL. Bruceantinol shows in vitro inhibitory activity against Trypanosoma evansi.
    Targets: Antifection
    In vitro:
    Virus Res. 2017 Jan 2;227:49-56.
    Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper.[Pubmed: 27686478 ]

    METHODS AND RESULTS:
    A green fluorescent protein (GFP)-tagged pepper mottle virus (PepMoV) based leaf-disc method and systemic host method were developed to identify antiviral agents. Preliminary experiments using a PepMoV-GFP based leaf-disc method led to the isolation of five quassinoids, including brusatol (1), bruceantin (2), brucein A (3), bruceantinol (4), and brucein B (5), from the CH3OH extract of Brucea javanica.
    CONCLUSIONS:
    All isolated compounds exhibited inactivation effects in systemic host plants, and compounds 3 and 4 were potent, with a minimum inhibitory concentration of 10μM. Furthermore, compound 3 was found to have a protective effect at the tested concentration of 40μM.
    J Nat Prod. 2007 Oct;70(10):1654-7.
    Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica.[Pubmed: 17896817]
    Boiled extracts derived from 28 Indonesian medicinal plants were screened for their antibabesial activity against Babesia gibsoni in vitro.
    METHODS AND RESULTS:
    Of these extracts, the fruit of Brucea javanica was the most active in inhibiting parasite growth at a concentration of 10 microg/mL. Bioassay-guided fractionation of the fruit extract of Br. javanica led to the isolation of two new quassinoids, Bruceantinol B and bruceine J, and the structures of these compounds were elucidated on the basis of their spectroscopic data and by chemical transformation to known compounds. In addition, the known quassinoids bruceines A-D, Bruceantinol, and yadanziolide A were isolated.
    CONCLUSIONS:
    Antibabesial activities were also examined in vitro, and bruceine A and Bruceantinol were shown to be more potent than diminazene aceturate, a drug (IC50 = 103 ng/mL) used clinically against B. gibsoni, with IC50 values of 4 and 12 ng/mL, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6485 mL 8.2424 mL 16.4848 mL 32.9696 mL 41.212 mL
    5 mM 0.3297 mL 1.6485 mL 3.297 mL 6.5939 mL 8.2424 mL
    10 mM 0.1648 mL 0.8242 mL 1.6485 mL 3.297 mL 4.1212 mL
    50 mM 0.033 mL 0.1648 mL 0.3297 mL 0.6594 mL 0.8242 mL
    100 mM 0.0165 mL 0.0824 mL 0.1648 mL 0.3297 mL 0.4121 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鸦胆子苷P; Yadanzioside P CFN96417 79439-84-2 C34H46O16 = 710.72 5mg QQ客服:1457312923
    鸦胆子苷L ; Yadanzioside L CFN96419 99132-97-5 C34H46O17 = 726.72 5mg QQ客服:1413575084
    鸦胆子苷K; Yadanzioside K CFN96420 101559-98-2 C36H48O18 = 768.76 5mg QQ客服:1413575084
    13,18-二氢乐园树酮; 13,18-Dehydroglaucarubinone CFN92980 68703-94-6 C25H32O10 = 492.52 5mg QQ客服:1457312923
    (+)-乐园树酮; (+)-Glaucarubinone CFN92979 1259-86-5 C25H34O10 = 494.53 5mg QQ客服:2159513211
    鸦胆子素B; Bruceine B CFN89335 25514-29-8 C23H28O11 = 480.46 5mg QQ客服:3257982914
    鸦胆子素C; Bruceine C CFN91974 25514-30-1 C28H36O12 = 564.58 5mg QQ客服:2159513211
    鸦胆醇; Bruceantinol CFN89336 53729-52-5 C30H38O13 = 606.62 5mg QQ客服:1457312923
    鸦胆亭醇B; Bruceantinol B CFN95216 1822332-33-1 C27H34O12 = 550.6 5mg QQ客服:3257982914
    鸦胆亭醇; Bruceantinol A CFN91971 948038-36-6 C29H36O13 = 592.59 5mg QQ客服:2159513211

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