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  • 构树宁A

    Broussonin A

    构树宁A
    产品编号 CFN97694
    CAS编号 73731-87-0
    分子式 = 分子量 C16H18O3 = 258.32
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The branches of Broussonetia papyrifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    构树宁A CFN97694 73731-87-0 1mg QQ客服:3257982914
    构树宁A CFN97694 73731-87-0 5mg QQ客服:3257982914
    构树宁A CFN97694 73731-87-0 10mg QQ客服:3257982914
    构树宁A CFN97694 73731-87-0 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Anna University (India)
  • Max-Planck-Insitut (Germany)
  • Center for protein Engineering (CIP) (Belgium)
  • Shanghai Institute of Organic Chemistry (China)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Universidade do Porto (Portugal)
  • University of Queensland (Australia)
  • Universidad Industrial de Santander (Colombia)
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  • Yale University (USA)
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  • University of Maryland School of Medicine (USA)
  • The University of Newcastle (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • JPC-Journal of Planar Chromatography2023, 36:179-190
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Nutr Res Pract.2020, 14(3):203-217.
  • J Ethnopharmacol.2021, 267:113615.
  • Fitoterapia.2022, 105141.
  • Cytotechnology.2017, 69(5):765-773
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • J Med Food.2016, 19(12):1155-1165
  • J Appl Biol Chem.2021, 64(3),263?268
  • Advances in Traditional Medicine 2021, 21:779-789.
  • J Med Food.2021, 24(3):209-217.
  • Research Square2023, 2883170.
  • J Pharm Biomed Anal.2016, 129:50-59
  • Phytomedicine.2016, 23(4):331-9
  • Journal of Apicultural Research2021, 60(1)
  • Planta Med.2022, 88(9-10):794-804.
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Int Immunopharmacol.2019, 71:22-31
  • Clin Transl Oncol.2019, 10.1007
  • JEJU National University2022, 24032.
  • Univerzita Karlova2021, 20.500.11956.
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • Biochem Pharmacol.2017, 130:10-20
  • ...
  • 生物活性
    Description: Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A can significantly inhibit adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay; it suppresses lipopolysaccharide (LPS)-stimulated inducible nitric oxide synthase (iNOS) expression at the transcriptional level through modulating NF-κB and down-regulation of the Akt and ERK signaling pathways.
    Targets: NOS | Akt | ERK | Estrogen receptor | IFN-γ | IL Receptor | NF-kB | IkB | IKK | Progestogen receptor
    In vitro:
    Chem Biodivers. 2014 May;11(5):749-59.
    Suppression of inducible nitric oxide synthase expression by nyasol and broussonin A, two phenolic compounds from Anemarrhena asphodeloides, through NF-κB transcriptional regulation in vitro and in vivo.[Pubmed: 24827684]
    Anemarrhena asphodeloides is widely used in traditional Chinese medicine, and is known to possess antidiabetic and anti-inflammatory properties.
    METHODS AND RESULTS:
    Because inducible nitric oxide synthase (iNOS) plays an important role in inflammation, we investigated the inhibitory effects of two known phenolic compounds, nyasol (1) and broussonin A (2), from A. asphodeloides, on iNOS and its plausible mechanism of action. Compounds 1 and 2 exhibited inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Compounds 1 and 2 also suppressed the expressions of iNOS protein and mRNA. Moreover, compounds 1 and 2 suppressed the expression of inflammatory cytokines such as interleukin-1β (IL-1β) and interferon-β (IFN-β). They also inhibited the transcriptional activity of NF-κB and degradation of IκB-α, as well as the activation of Akt and ERK in LPS-stimulated RAW 264.7 cells. In in vivo animal model, compounds 1 and 2 significantly inhibited TPA-induced mouse ear edema.
    CONCLUSIONS:
    These results suggest that 1 and 2 suppress LPS-stimulated iNOS expression at the transcriptional level through modulating NF-κB and down-regulation of the Akt and ERK signaling pathways. Taken together, these findings indicate that the suppressive effects of 1 and 2 on iNOS expression might provide one possible mechanism for their anti-inflammatory activities.
    Bioorg Med Chem Lett. 2010 Jun 15;20(12):3764-7.
    New estrogenic compounds isolated from Broussonetia kazinoki.[Pubmed: 20493686 ]

    METHODS AND RESULTS:
    Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4).
    CONCLUSIONS:
    They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8712 mL 19.3558 mL 38.7117 mL 77.4234 mL 96.7792 mL
    5 mM 0.7742 mL 3.8712 mL 7.7423 mL 15.4847 mL 19.3558 mL
    10 mM 0.3871 mL 1.9356 mL 3.8712 mL 7.7423 mL 9.6779 mL
    50 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.5485 mL 1.9356 mL
    100 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.7742 mL 0.9678 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    构树宁A; Broussonin A CFN97694 73731-87-0 C16H18O3 = 258.32 5mg QQ客服:1413575084
    构树宁C; Broussonin C CFN97690 76045-49-3 C20H24O3 = 312.41 5mg QQ客服:1457312923
    1-(4-羟基-2-甲氧基苯基)-3-(4-羟基-3-异戊烯基苯基)丙烷; 1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane CFN98607 376362-03-7 C21H26O3 = 326.4 5mg QQ客服:215959384
    1-羟基-1-(4-羟基-2-甲氧基苯基)-3-(4-羟基苯基)-2-丙酮; 1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one CFN97846 117614-84-3 C16H16O5 = 288.3 5mg QQ客服:2056216494
    Puerol A; Puerol A CFN96269 152784-32-2 C17H14O5 = 298.3 5mg QQ客服:1457312923
    (+)-Puerol B 2''-O-glucoside; (+)-Puerol B 2''-O-glucoside CFN97602 868409-19-2 C24H26O10 = 474.46 10mg QQ客服:1457312923
    Puerol B; Puerol B CFN95155 112343-17-6 C18H16O5 = 312.3 5mg QQ客服:2159513211
    Specioside B; Specioside B CFN95165 126589-95-5 C23H24O10 = 460.4 5mg QQ客服:1457312923
    葛根苷A; Pueroside A CFN95177 100692-52-2 C29H34O14 = 606.6 5mg QQ客服:215959384
    葛根苷C; Pueroside C CFN95156 112343-16-5 C24H26O10 = 474.5 5mg QQ客服:1413575084

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