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  • 旋覆花内酯

    Britannin

    旋覆花内酯
    产品编号 CFN90220
    CAS编号 33627-28-0
    分子式 = 分子量 C19H26O7 = 366.41
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Inula japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    旋覆花内酯 CFN90220 33627-28-0 10mg QQ客服:3257982914
    旋覆花内酯 CFN90220 33627-28-0 20mg QQ客服:3257982914
    旋覆花内酯 CFN90220 33627-28-0 50mg QQ客服:3257982914
    旋覆花内酯 CFN90220 33627-28-0 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Korea Institute of Oriental Medicine (Korea)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Toulouse (France)
  • Aveiro University (Portugal)
  • Chinese University of Hong Kong (China)
  • Julius Kühn-Institut (Germany)
  • University of Hertfordshire (United Kingdom)
  • Universidad Industrial de Santander (Colombia)
  • Kitasato University (Japan)
  • National Research Council of Canada (Canada)
  • Universidade Federal de Santa Catarina (Brazil)
  • Wageningen University (Netherlands)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Kor. J. Herbol.2019, 34(2):59-66
  • Front Immunol.2017, 8:1542
  • Institute of Food Science & Technology2021, 18 December.
  • J Pharm Biomed Anal2016, 118:183-194
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • Food and Fermentation Industries2019, 45(7):45-51
  • Plos One.2020, 10.1371
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Phytomedicine.2019, 55:229-237
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Analytical sci. & Tech2020, 33(5):224-231
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Appl. Sci.2020, 10(23), 8729
  • PLoS One.2018, 13(11):e0208055
  • Korean J Dent Mater2020, 47(2):63-70.
  • Rev. Chim.2020, 71(3),558-564
  • Sci Rep.2017, 7:40345
  • SRM Institute of Sci&Tech2022, 34(1): 32-37
  • Journal of Plant Growth Regulation2022, 10705-2.
  • Applied Biological Chemistry2022, 65(12)
  • Front Pharmacol.2022, 13:972825.
  • Food Res Int.2021, 148:110607.
  • Kor. J. Herbol.2022, 37(5): 89-96.
  • ...
  • 生物活性
    Description: Britannin has strong cytotoxicity to HepG-2, MCF-7, MDBK and A-549 cells (IC50: 2.2, 5.9, 5.4, and 3.5 microg/mL, respectively). Britannin inhibits growth of MCF-7 and MDA-MB-468 breast cancer cells through the activation of the mitochondrial apoptotic pathway and may potentially serve as an agent for breast cancer therapy.
    Targets: ROS | Bcl-2/Bax | Caspase | p53
    In vitro:
    Tumour Biol. 2015 Feb;36(2):1191-8.
    Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.[Pubmed: 25342596]
    Induction of apoptosis in cancer cells can be a promising treatment method in cancer therapy. Naturally derived products had drawn growing attention as agent in cancer therapy. The main target of anticancer drugs may be distinct, but eventually, they lead to identical cell death pathway, which is apoptosis.
    METHODS AND RESULTS:
    Here, we indicated that britannin, a sesquiterpene lactone isolated from Asteraceae family, has antiproliferative activity on the MCF-7 and MDA-MB-468 human breast cancer cells. Annexin V/propidium iodide (PI) staining, Hoechst 33258 staining, and caspase-3/9 activity assay confirmed that britannin is able to induce apoptosis in MCF-7 and MDA-MB-468 cells. The Western blot analysis showed that the expression of Bcl-2 was noticeably decreased in response to britannin treatment, while the expression of Bax protein was increased, which were positively correlated with elevated expression of p53. Moreover, britannin also increased reactive oxygen species (ROS) generation which in turn triggered the loss of mitochondrial transmembrane potential (ΔΨm) and the subsequent release of cytochrome c from mitochondria into cytosol.
    CONCLUSIONS:
    Taken together, these results suggest that britannin inhibits growth of MCF-7 and MDA-MB-468 breast cancer cells through the activation of the mitochondrial apoptotic pathway and may potentially serve as an agent for breast cancer therapy.
    Nat Prod Commun. 2012 Aug;7(8):979-80.
    Anti-proliferative activity and apoptotic potential of britannin, a sesquiterpene lactone from Inula aucheriana.[Pubmed: 22978209]
    Inula aucheriana n-hexane, CHCl3 and MeOH extracts were evaluated for their anti-proliferative activity against HepG-2, MCF-7, MDBK and A-549 cells.
    METHODS AND RESULTS:
    The CHCl3 extract exhibited cytotoxic activity to the above cell lines with IC50 values of 13.5, 23.4, 10.5, and 26.9 microg/mL, respectively. The sesquiterpene lactone britannin was isolated from the above extract. This was further evaluated in the MTT assay to demonstrate strong cytotoxicity to the mentioned cell lines (IC50: 2.2, 5.9, 5.4, and 3.5 microg/mL, respectively), and the apoptotic inducing properties of britannin were evaluated on human breast adenocarcinoma (MCF-7) cells through the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7292 mL 13.6459 mL 27.2918 mL 54.5837 mL 68.2296 mL
    5 mM 0.5458 mL 2.7292 mL 5.4584 mL 10.9167 mL 13.6459 mL
    10 mM 0.2729 mL 1.3646 mL 2.7292 mL 5.4584 mL 6.823 mL
    50 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.0917 mL 1.3646 mL
    100 mM 0.0273 mL 0.1365 mL 0.2729 mL 0.5458 mL 0.6823 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2beta-(异丁酰氧基)堆心菊内酯; 2beta-(Isobutyryloxy)florilenalin CFN91998 94898-78-9 C19H26O5 = 334.41 5mg QQ客服:2056216494
    4-表异粘性旋覆花内酯; 4-Epi-isoinuviscolide CFN97174 68832-39-3 C15H20O3 = 248.3 5mg QQ客服:1457312923
    Minimolide F; Minimolide F CFN92943 1367351-41-4 C19H26O5 = 334.41 5mg QQ客服:2056216494
    8-表-密花豚草素; 8-epi-Confertin CFN95509 110115-60-1 C15H20O3 = 248.3 5mg QQ客服:1413575084
    Dihydroconfertin; Dihydroconfertin CFN95523 68832-40-6 C15H22O3 = 250.3 5mg QQ客服:1457312923
    5-Hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on; 5-Hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on CFN95522 114579-31-6 C15H22O3 = 250.3 5mg QQ客服:215959384
    2-去氧-4-表-天人菊灵; 2-Desoxy-4-epi-pulchellin CFN99345 122872-03-1 C15H22O3 = 250.3 20mg QQ客服:2159513211
    Carabrolactone B; Carabrolactone B CFN99287 1187925-31-0 C15H22O4 = 266.3 5mg QQ客服:3257982914
    旋覆花内酯; Britannin CFN90220 33627-28-0 C19H26O7 = 366.41 20mg QQ客服:2056216494
    麦角内酯; Ergolide CFN91552 54999-07-4 C17H22O5 = 306.4 10mg QQ客服:2056216494

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