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  • (-)-白果内酯

    (-)-Bilobalide

    (-)-白果内酯
    产品编号 CFN99789
    CAS编号 33570-04-6
    分子式 = 分子量 C15H18O8 = 326.30
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Sesquiterpenoids
    植物来源 The leaves of Ginkgo biloba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    (-)-白果内酯 CFN99789 33570-04-6 10mg QQ客服:3257982914
    (-)-白果内酯 CFN99789 33570-04-6 20mg QQ客服:3257982914
    (-)-白果内酯 CFN99789 33570-04-6 50mg QQ客服:3257982914
    (-)-白果内酯 CFN99789 33570-04-6 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Seoul National University of Science and Technology (Korea)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Maryland School of Medicine (USA)
  • University of Indonesia (Indonesia)
  • University of Cincinnati (USA)
  • Aveiro University (Portugal)
  • Charles Sturt University (Denmark)
  • Universiti Kebangsaan Malaysia (Malaysia)
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  • National Research Council of Canada (Canada)
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  • S.N.D.T. Women's University (India)
  • Auburn University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2020, 9(2):E99
  • J Med Food.2022, 25(3):272-280.
  • Food Research International2023, 113792.
  • Cancers (Basel).2023, 15(1):37.
  • Foods.2022, 11(12):1708.
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • Kor. J. Herbol.2019, 34(2):59-66
  • J Cell Mol Med.2023, jcmm.17968.
  • Biomolecules.2023, 13(2):227.
  • Nutr Res Pract.2020, 14(3):203-217.
  • Mol Med Rep.2024, 29(2):26.
  • Int J Mol Sci.2017, 19(1)
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Aquaculture2017, 481:94-102
  • Asian Pac J Tropical Bio.2020, 10(6):239-247
  • Toxins (Basel).2019, 11(10):E575
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • J Pharm Biomed Anal.2017, 140:274-280
  • J Sep Sci.2018, 41(11):2488-2497
  • Nutrients.2023, 15(3):753.
  • Acta Physiologiae Plantarum2016, 38:7
  • Phytomedicine.2016, 23(4):331-9
  • Phytochem Anal.2022, doi: 10.1002
  • ...
  • 生物活性
    Description: Bilobalide possesses anticonvulsant, insecticidal, and cardioprotective effects. Bilobalide exerts protective and trophic effects on neurons, the PI3K/Akt pathway may be involved in the protective effects of bilobalide; it also can protect PC12 cells from A beta 25-35-induced cytotoxicity, it dose-dependently attenuates the cytotoxic effect of A beta 25-35.
    Targets: PAFR | Beta Amyloid | PI3K | Akt | ERK | PKC | Serine
    In vitro:
    Acta Pharmacol Sin. 2000 Jan;21(1):75-9.
    Protective effects of bilobalide on amyloid beta-peptide 25-35-induced PC12 cell cytotoxicity.[Pubmed: 11263252]
    To study the effect of bilobalide[(-)-Bilobalide], a terpene extracted from the leaves of Ginkgo biloba, on beta-amyloid peptide fragment 25-35 (A beta 25-35)-induced PC12 cell cytotoxicity.
    METHODS AND RESULTS:
    3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide and lactate dehydrogenase assay were used to measure the viability of PC12 cells. Thiobarbituric acid-reactive substances were measured to determine lipid peroxidation of cells. Antioxidant enzymes in PC12 cells were detected. Treatment of PC12 cells with A beta 25-35 (100 mumol.L-1) for 24 h caused a great decrease in cell viability (P < 0.01 compared with control). Bilobalide[(-)-Bilobalide] 25-100 mumol.L-1 dose-dependently attenuated the cytotoxic effect of A beta 25-35. Bilobalide[(-)-Bilobalide] also inhibited A beta 25-35 (100 mumol.L-1)-induced elevation of lipid peroxidation and decline of antioxidant enzyme activities.
    CONCLUSIONS:
    Bilobalide[(-)-Bilobalide] protected PC12 cells from A beta 25-35-induced cytotoxicity.
    Apoptosis . 2010 Jun;15(6):715-27.
    Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells[Pubmed: 20333467]
    Abstract Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba leaf extracts, has been proposed to exert protective and trophic effects on neurons. However, mechanisms underlying the protective effects of bilobalide remain unclear. Using human SH-SY5Y neuroblastoma cells and primary hippocampal neurons, this study investigated the neuroprotective effects of bilobalide. We mimicked aging-associated neuronal impairments by applying external factors (beta amyloid protein (Abeta) 1-42, H(2)O(2) and serum deprivation) consequently inducing cell apoptosis. As markers for apoptosis, cell viability, DNA fragmentation, mitochondrial membrane potential and levels of cleaved caspase 3 were measured. We found that, bilobalide prevented Abeta 1-42-, H(2)O(2)- and serum deprivation-induced apoptosis. To better understand the neuroprotective effects of bilobalide, we also tested the ability of bilobalide to modulate pro-survival signaling pathways such as protein kinase C (PKC), extracellular-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/Akt pathways. It was found that, bilobalide dose-dependently increased PI3K activity and levels of phosphorylated Akt (p-Akt Ser473 and Thr308), which could be maintained up to at least 2 h after bilobalide withdrawal in cells treated with or without Abeta 1-42, H(2)O(2) or serum-free medium. In addition, application of PI3K/Akt inhibitor LY294002 could abrogate both the protective effects of bilobalide against Abeta 1-42-, H(2)O(2)- and serum deprivation-induced apoptotic cell damage and bilobalide-induced increase in PI3K activity and levels of p-Akt (Ser473 and Thr308). In contrast, application of PKC inhibitor staurosporine (STS) did not affect the protective effects of bilobalide. Moreover, no change in levels of phosphorylated ERK1/2 (p-ERK1/2) was observed in bilobalide-treated cells. These results further suggested that the PI3K/Akt pathway might be involved in the protective effects of bilobalide. Since modern technology allows production of purified bilobalide with high bioavailability, bilobalide may be useful in developing therapy for diseases involving age-associated neurodegeneration.
    In vivo:
    Eur J Pharmacol. 1999 Feb 19;367(2-3):165-73.
    Effects of bilobalide on gamma-aminobutyric acid levels and glutamic acid decarboxylase in mouse brain.[Pubmed: 10078989]
    We have previously demonstrated that Bilobalide[(-)-Bilobalide] a constituent of the Ginkgo biloba extract, possesses anticonvulsant activity, and suggested that the mechanism of its anticonvulsant action involves modulation of y-aminobutyric acid (GABA)-related neuronal transmission.
    METHODS AND RESULTS:
    This study examined the effects of Bilobalide[(-)-Bilobalide] on the level of GABA and glutamate, the activity and the amount of glutamic acid decarboxylase (EC 4.1.1.15), and the function of GABA(A) receptors in the hippocampus, cerebral cortex and striatum of the mouse. GABA levels, glutamic acid decarboxylase activity, and the protein amount of 67 kDa glutamic acid decarboxylase in the hippocampus of mice treated withBilobalide[(-)-Bilobalide] (30 mg/kg, p.o., once a day for 4 days) were significantly higher than those in controls. However, there were no significant differences in glutamate levels or, the number and the dissociation constants of GABA(A) receptors in the hippocampus between control and bilobalide-treated mice.
    CONCLUSIONS:
    These results suggest that the anticonvulsant effect of bilobalide is due to elevation of GABA levels, possibly through potentiation of glutamic acid decarboxylase activity and enhancement of the protein amount of 67 kDa glutamic acid decarboxylase by bilobalideBilobalide[(-)-Bilobalide].
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0647 mL 15.3233 mL 30.6466 mL 61.2933 mL 76.6166 mL
    5 mM 0.6129 mL 3.0647 mL 6.1293 mL 12.2587 mL 15.3233 mL
    10 mM 0.3065 mL 1.5323 mL 3.0647 mL 6.1293 mL 7.6617 mL
    50 mM 0.0613 mL 0.3065 mL 0.6129 mL 1.2259 mL 1.5323 mL
    100 mM 0.0306 mL 0.1532 mL 0.3065 mL 0.6129 mL 0.7662 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Cyclocalopin A; Cyclocalopin A CFN98771 486430-94-8 C15H20O6 = 296.3 5mg QQ客服:1457312923
    O-Acetylcyclocalopin A; O-Acetylcyclocalopin A CFN98770 486430-93-7 C17H22O7 = 338.4 5mg QQ客服:1457312923
    (-)-白果内酯; (-)-Bilobalide CFN99789 33570-04-6 C15H18O8 = 326.30 20mg QQ客服:1457312923

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