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  • 双白术内酯

    Biatractylolide

    双白术内酯
    产品编号 CFN95205
    CAS编号 182426-37-5
    分子式 = 分子量 C30H38O4 = 462.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Atractylodes macrocephala
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    双白术内酯 CFN95205 182426-37-5 1mg QQ客服:2159513211
    双白术内酯 CFN95205 182426-37-5 5mg QQ客服:2159513211
    双白术内酯 CFN95205 182426-37-5 10mg QQ客服:2159513211
    双白术内酯 CFN95205 182426-37-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University Medical Center Mainz (Germany)
  • Lund University (Sweden)
  • Rio de Janeiro State University (Brazil)
  • Kazusa DNA Research Institute (Japan)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • The University of Newcastle (Australia)
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  • University of Melbourne (Australia)
  • Osmania University (India)
  • University of Parma (Italy)
  • Medizinische Universit?t Wien (Austria)
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  • Sapienza University of Rome (Italy)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2020, 12(12):3607.
  • Molecules.2018, 23(11):E2837
  • Appl. Sci. 2021, 11(17),7829
  • Arch Biochem Biophys.2020, 687:108384.
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Rev. Chim.2020, 71(3),558-564
  • Biomed Chromatogr.2020, e5021.
  • J Pharm Biomed Anal.2023, 234:115570.
  • Antioxidants.2022, 11(3):491.
  • Food Funct.2020, 11(2):1322-1333.
  • Preprints2022, 202211.0388.v1.
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Saudi Pharm J2020, 10.1016
  • Nat Prod Sci.2014, 20(3):182-190
  • Phytochemistry Letters2021, 43:80-87.
  • J Adv Res.2019, 17:85-94
  • Phytomedicine.2018, 47:48-57
  • Am J Chin Med.2022, 1-20.
  • J Nat Med.2020, 74(1):65-75
  • Foods. 2022, 11(23):3905.
  • BMC Plant Biol.2022, 22(1):128.
  • Food Sci Nutr.2019, 8(1):246-256
  • Acta Biochim Pol.2015, 62(2):253-8
  • ...
  • 生物活性
    Description: Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways. The molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only through binding to AChE, but also via reducing AChE expression by inhibiting the activity of GSK3β.
    Targets: PI3K | Akt | GSK3β | AChR
    In vitro:
    Evid Based Complement Alternat Med. 2017;2017:1291458.
    Biatractylolide Modulates PI3K-Akt-GSK3β-Dependent Pathways to Protect against Glutamate-Induced Cell Damage in PC12 and SH-SY5Y Cells.[Pubmed: 29075302]
    Biatractylolide, isolated from the ethyl acetate extract of Atractylodes macrocephala, has shown various pharmacological activities such as antitumor and antioxidant activities.
    CONCLUSIONS:
    In this work, we aim to study the protective effect of biatractylolide on glutamate-induced rat adrenal pheochromocytoma cell (PC12) and human bone marrow neuroblastoma cell line (SH-SY5Y) injury and preliminarily explore its mechanism. The results showed that glutamate was cytotoxic with an inhibitory concentration 50% (IC50) of 8.5 mM in PC12 and 10 mM in SH-SY5Y cells. In this work, the preincubation with biatractylolide (10, 15, and 20 μM) observably improved cell viability, inhibited the apoptosis of cells induced by glutamate, and reduced the activity of LDH. AO staining revealed that apoptosis of cells was decreased. Additionally, the results of western blotting manifested that pretreatment with biatractylolide could downregulate GSK3β protein expression and upregulate p-Akt protein expression, thereby protecting PC12 and SH-SY5Y cells from injury.
    CONCLUSIONS:
    All these findings indicate that biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1617 mL 10.8085 mL 21.6169 mL 43.2339 mL 54.0424 mL
    5 mM 0.4323 mL 2.1617 mL 4.3234 mL 8.6468 mL 10.8085 mL
    10 mM 0.2162 mL 1.0808 mL 2.1617 mL 4.3234 mL 5.4042 mL
    50 mM 0.0432 mL 0.2162 mL 0.4323 mL 0.8647 mL 1.0808 mL
    100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.4323 mL 0.5404 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芹烷二烯酮; Selina-4(15),7(11)-dien-8-one CFN95078 54707-47-0 C15H22O = 218.3 10mg QQ客服:3257982914
    Chlorantholide A; Chlorantholide A CFN97968 1372558-33-2 C15H16O3 = 244.3 5mg QQ客服:3257982914
    Chlorantholide B; Chlorantholide B CFN97967 1372558-34-3 C15H18O3 = 246.3 5mg QQ客服:2056216494
    Chlorantholide C; Chlorantholide C CFN97970 1372558-35-4 C15H18O3 = 246.3 5mg QQ客服:1413575084
    Chlorantholide D; Chlorantholide D CFN97956 1253106-58-9 C15H18O4 = 262.3 5mg QQ客服:1413575084
    Chlorantholide E; Chlorantholide E CFN97969 1372558-36-5 C15H18O5 = 278.3 5mg QQ客服:2159513211
    4alpha,6alpha-Dihydroxyeudesm-11(13)-en-12,8beta-olide; 4alpha,6alpha-Dihydroxyeudesm-11(13)-en-12,8beta-olide CFN89139 35001-19-5 C15H22O4 = 266.33 5mg QQ客服:1413575084
    Wedelialactone A; Wedelialactone A CFN96439 175862-40-5 C24H34O8 = 450.53 5mg QQ客服:3257982914
    6-O-Methacryloyltrilobolide; 6-O-Methacryloyltrilobolide CFN89319 950685-51-5 C23H30O9 = 450.48 5mg QQ客服:215959384
    Wedeliatrilolactone A; Wedeliatrilolactone A CFN96438 156993-29-2 C23H32O9 = 452.49 5mg QQ客服:3257982914

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