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  • β-倒捻子素

    Beta-mangostin

    β-倒捻子素
    产品编号 CFN99723
    CAS编号 20931-37-7
    分子式 = 分子量 C25H28O6 = 424.49
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Xanthones
    植物来源 The fruits of Garcinia mangostana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    β-倒捻子素 CFN99723 20931-37-7 1mg QQ客服:2056216494
    β-倒捻子素 CFN99723 20931-37-7 5mg QQ客服:2056216494
    β-倒捻子素 CFN99723 20931-37-7 10mg QQ客服:2056216494
    β-倒捻子素 CFN99723 20931-37-7 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Copenhagen University (Denmark)
  • Medical University of Gdansk (Poland)
  • Medizinische Universit?t Wien (Austria)
  • Stanford University (USA)
  • Universidade Federal de Santa Catarina (Brazil)
  • Aveiro University (Portugal)
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  • Harvard University (USA)
  • Colorado State University (USA)
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  • University of Cincinnati (USA)
  • Periyar University (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Pharmacol2020, 16:1-9
  • HortTechnology2016, 26(6):816-819
  • Molecules2020, 25(4):892
  • Molecules.2023, 28(13):4971.
  • Eur J Pharmacol.2020, 889:173589.
  • Metabolites.2023, 13(5):625.
  • Cell Rep.2020, 32(11):108158.
  • The Journal of Phytopharmacology2020, 9(1): 1-4
  • Appl. Sci. 2021, 11(17),7829
  • Aquaculture2017, 481:94-102
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Appl. Sci.2020, 10(5),1713.
  • bioRxiv2021, 462065.
  • J Agric Food Chem.2020, 68(51):15164-15175
  • J Sep Sci.2018, 41(7):1682-1690
  • J Nat Med.2022, 76(1):59-67.
  • J Biomed Sci.2020, 27(1):60.
  • Int Immunopharmacol.2023, 7:127:111322.
  • Nutrients.2021, 13(12):4364.
  • Preprints2017, 2017120176
  • APMIS.2019, 127(10):688-695
  • Horticulture Research2020, 7:111.
  • J Bone Miner Res.2017, 32(12):2415-2430
  • ...
  • 生物活性
    Description: Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity against B. cereus, and Mycobacterium tuberculosis with the MIC value of 0.25, and 6.25 microg/ml, respectively. It also shows antimalarial activity against Plasmodium falciparum with IC(50) values of 7.2 microg/ml.
    Targets: COX | TNF-α | PGE | NF-kB | IL Receptor | Antifection
    In vitro:
    J Ethnopharmacol. 2014 Apr 28;153(2):435-45.
    β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo.[Pubmed: 24607509]
    The fruit hull of Garcinia mangostana Linn. has been used in traditional medicine for treatment of various inflammatory diseases. Hence, this study aims to investigate the in vitro and in vivo anti-inflammatory effect of β mangostin (βM), a major compound present in Garcinia mangostana.
    METHODS AND RESULTS:
    The in silico analysis of inflammatory mediators such as cyclooxygenase (COX) and nuclear factor-kappa B (NF-kB) were performed via molecular docking. Further evaluation of anti-inflammatory effect was conducted in lipopolysaccharide (LPS) induced RAW 264.7 macrophages. Suppression of activated NF-kB was analyzed by high content screening. βM triggered inhibition of COX-1 and COX-2 in vitro were studied using biochemical kit. The in vivo model used in this study was carrageenan-induced peritonitis model, where reduction in carrageenan-induced peritonitis is measured by leukocyte migration and vascular permeability. In addition, the evaluation of βM׳s effect on carrageenan induced TNF-α and IL-1β release on peritoneal fluid was also carried out. Treatment with βM could inhibit the LPS-induced NO production but not the viability of RAW 264.7. Similarly, βM inhibited PGE2 production and the cytokines: TNF-α and IL-6. The COX catalyzed prostaglandin biosynthesis assay had showed selective COX-2 inhibition with a 53.0±6.01% inhibition at 20 μg/ml. Apart from this, βM was capable in repressing translocation of NF-kB into the nucleus. These results were concurrent with molecular docking which revealed COX-2 selectivity and NF-kB inhibition. The in vivo analysis showed that after four hours of peritonitis, βM was unable to reduce vascular permeability, yet could decrease the total leukocyte migration; particularly, neutrophils. Meanwhile, dexamethasone 0.5 mg/kg, successfully reduced vascular permeability. The levels of TNF-α and IL-1β in peritoneal fluid was reduced significantly by βM treatment.
    CONCLUSIONS:
    The current study supports the traditional use of Garcinia mangostana fruit hull for treatment of inflammatory conditions. In addition, it is clear that the anti-inflammatory efficacy of this plant is not limited to the presence of α and γ, but β also with significant activity.
    Fitoterapia. 2014 Oct;98:179-83.
    Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa.[Pubmed: 25110196]

    METHODS AND RESULTS:
    A phytochemical investigation of the acetone extract from the immature fruits of Garcinia cowa led to the isolation of two novel tetraoxygenated xanthones, garcicowanones A (1) and B (2), together with eight known tetraoxygeanted xanthones. Their structures were determined by spectroscopic analysis.All isolated compounds were evaluated for their antibacterial activity against Bacillus cereus TISTR 688, Bacillus subtilis TISTR 008, Micrococcus luteus TISTR 884, Staphylococcus aureus TISTR 1466, Escherichia coli TISTR 780, Pseudomonas aeruginosa TISTR 781, Salmonella typhimurium TISTR 292 and Staphylococcus epidermidis ATCC 12228.
    CONCLUSIONS:
    α-Mangostin showed potent activity (MIC 0.25-1 μg/mL) against three Gram-positive strains and garcicowanone A and Beta-mangostin exhibited strong antibacterial activity against B. cereus with the same MIC values of 0.25 μg/mL.
    Tumour Biol . 2017 Nov;39(11):1010428317731451.
    Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G 0/G 1 cell-cycle arrest[Pubmed: 29110583]
    Abstract Xanthones are phytochemical compounds found in a number of fruits and vegetables. Characteristically, they are noted to be made of diverse properties based on their biological, biochemical, and pharmacological actions. Accordingly, the apoptosis mechanisms induced by beta-mangostin, a xanthone compound isolated from Cratoxylum arborescens in the human promyelocytic leukemia cell line (HL60) in vitro, were examined in this study. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was done to estimate the cytotoxicity effect of β-mangostin on the HL60 cell line. Acridine orange/propidium iodide and Hoechst 33342 dyes and Annexin V tests were conducted to detect the apoptosis features. Caspase-3 and caspase-9 activities; reactive oxygen species; real-time polymerase chain reaction for Bcl-2, Bax, caspase-3, and caspase-9 Hsp70 genes; and western blot for p53, cytochrome c, and pro- and cleavage-caspase-3 and caspase-9 were assessed to examine the apoptosis mechanism. Cell-cycle analysis conducted revealed that β-mangostin inhibited the growth of HL60 at 58 μM in 24 h. The administration of β-mangostin with HL60 caused cell morphological changes related to apoptosis which increased the number of early and late apoptotic cells. The β-mangostin-catalyzed apoptosis action through caspase-3, caspase-7, and caspase-9 activation overproduced reactive oxygen species which downregulated the expression of antiapoptotic genes Bcl-2 and HSP70. Conversely, the expression of the apoptotic genes Bax, caspase-3, and caspase-9 were upregulated. Meanwhile, at the protein level, β-mangostin activated the formation of cleaved caspase-3 and caspase-9 and also upregulated the p53. β-mangostin arrested the cell cycle at the G0/G1 phase. Overall, the results for β-mangostin showed an antiproliferative effect in HL60 via stopping the cell cycle at the G0/G1 phase and prompted the intrinsic apoptosis pathway. Keywords: Apoptosis; HL60 cell line; beta-mangostin; intrinsic pathway; leukemia; xanthones.
    Environ Toxicol . 2017 Nov;32(11):2360-2370.
    β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways[Pubmed: 28722351]
    Abstract β-mangostin is a dietary xanthone that has been reported to have the anticancer properties in some human cancer cell types. However, the antimetastatic effect and molecular mechanism of β-mangostin action in human hepatocellular carcinoma (HCC) cells remain unknown. In this study, we found that β-mangostin did not induce cytotoxicity in human HCC cells (SK-Hep-1, Huh-7 and HA22T/VGH cells). β-mangostin could inhibit migration and invasion of human HCC cells. Meanwhile, β-mangostin significantly decreased the protein activities and expression of matrix metalloproteinase (MMP)-2 and MMP-9 via increasing the activation of MEK1/2, ERK1/2, MEK4 and JNK1/2 signaling pathways. Furthermore, using specific inhibitor for ERK1/2 (PD98059) and JNK1/2 (JNKII) significantly restored the expression of MMP-2/-9 and invasion by β-mangostin treatment in Huh-7 cells. In addition, β-mangostin effectively restored the protein levels and transcription activity of MMP-2 and MMP-9 in siERK or siJNK-transfected Huh-7 cells, concomitantly with promotion on cell migration and invasion. Taken together, these findings are the first to demonstrate the antimetastatic activity of β-mangostin against human HCC cells, which may act as a promising therapeutic agent for the treatment of HCC. Keywords: MMP-2; MMP-9; hepatocellular carcinoma cell; invasion; migration; β-Mangostin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3558 mL 11.7788 mL 23.5577 mL 47.1154 mL 58.8942 mL
    5 mM 0.4712 mL 2.3558 mL 4.7115 mL 9.4231 mL 11.7788 mL
    10 mM 0.2356 mL 1.1779 mL 2.3558 mL 4.7115 mL 5.8894 mL
    50 mM 0.0471 mL 0.2356 mL 0.4712 mL 0.9423 mL 1.1779 mL
    100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.4712 mL 0.5889 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    伽升沃D; Garcinone D CFN90383 107390-08-9 C24H28O7 = 428.48 20mg QQ客服:215959384
    伽升沃C; Garcinone C CFN97254 76996-27-5 C23H26O7 = 414.5 10mg QQ客服:215959384
    γ-倒捻子素; gamma-Mangostin CFN98396 31271-07-5 C23H24O6 = 396.4 20mg QQ客服:1413575084
    α-倒捻子素; alpha-Mangostin CFN97050 6147-11-1 C24H26O6 = 410.5 20mg QQ客服:2056216494
    β-倒捻子素; Beta-mangostin CFN99723 20931-37-7 C25H28O6 = 424.49 10mg QQ客服:215959384
    黄牛木酮; Cratoxylone CFN93577 149155-01-1 C24H28O7 = 428.5 5mg QQ客服:2159513211
    β-倒捻子素类似物2号; Cowaxanthone B CFN93911 212842-64-3 C25H28O6 = 424.5 5mg QQ客服:1413575084
    β-倒捻子素类似物1号; Fuscaxanthone C CFN93676 15404-76-9 C26H30O6 = 438.5 5mg QQ客服:1413575084

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