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  • 马兜铃内酰胺BII

    Aristolactam BII

    马兜铃内酰胺BII
    产品编号 CFN98903
    CAS编号 53948-09-7
    分子式 = 分子量 C17H13NO3 = 279.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The herbs of Aristolochia debilis Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    马兜铃内酰胺BII CFN98903 53948-09-7 1mg QQ客服:215959384
    马兜铃内酰胺BII CFN98903 53948-09-7 5mg QQ客服:215959384
    马兜铃内酰胺BII CFN98903 53948-09-7 10mg QQ客服:215959384
    马兜铃内酰胺BII CFN98903 53948-09-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of the Basque Country (Spain)
  • National Cancer Institute (USA)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Kyushu University (Japan)
  • St. Jude Children Research Hospital (USA)
  • University of Queensland (Australia)
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  • University of Auckland (New Zealand)
  • Medical University of Gdansk (Poland)
  • Regional Crop Research Institute (Korea)
  • Universit?t Basel (Switzerland)
  • Griffith University (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2020, 21(9):3239.
  • J Ethnopharmacol.2022, 291:115159.
  • Front Microbiol.2021, 12:736780.
  • Molecules.2018, 23(12):E3103
  • Biofactors.2018, 44(2):168-179
  • Industrial Crops and Products2022, 188:115596.
  • Sci Rep. 2018, 1-9
  • Bio-protocol2018, 9(14):e3301
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • Theranostics.2023, 13(9):3103-3116.
  • Planta Med.2019, 85(4):347-355
  • Korean J Acupunct2020, 37:104-121
  • Crystals2020, 10(3), 206.
  • Int Immunopharmacol.2023, 7:127:111322.
  • Nat Prod Commun.2014, 9(5):679-82
  • Antioxidants (Basel).2021, 10(11): 1802.
  • Natural Product Communications2021, 16(9):1-10.
  • Int Immunopharmacol.2022, 106:108603.
  • Front Pharmacol.2019, 10:1226
  • HIV Med.2021, 22(8):690-704.
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • UDC.2020, 19(4).
  • ...
  • 生物活性
    Description: Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effects against tyrosinase mushroom. Aristolactam BII also exerts its significant neuroprotective effects on glutamate-injured primary cultures of rat cortical cells by directly inhibiting the production of nitric oxide.
    Targets: NO | HIV
    In vitro:
    Planta Med. 2004 May;70(5):391-6.
    Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production.[Pubmed: 15124081]
    Saurolactam and Aristolactam BII, aristolactam-type alkaloids isolated from the aerial part of Saururus chinensis (Lour.) Ball (Saururaceae), showed significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells.
    METHODS AND RESULTS:
    The action mechanism of Aristolactam BII, the more potent neuroprotective compound, was investigated using primary cultures of rat cortical cells as an in vitro system. Aristolactam BII attenuated glutamate-induced neurotoxicity significantly when it was added immediately or up to 9 h after the excitotoxic glutamate challenge. The alkaloid could not protect cultured neuronal cells from neurotoxicity induced by kainic acid or N-methyl- D-aspartate in a pre-treatment paradigm. However, Aristolactam BII successfully reduced the overproduction of nitric oxide and the level of cellular peroxide in cultured neurons when it was treated as a post-treatment paradigm.
    CONCLUSIONS:
    These results may suggest that Aristolactam BII exerts its significant neuroprotective effects on glutamate-injured primary cultures of rat cortical cells by directly inhibiting the production of nitric oxide.
    Nat Prod Commun. 2010 Feb;5(2):253-8.
    Aristolactams, 1-(2-C-methyl-beta-D-ribofuranosyl)-uracil and other bioactive constituents of Toussaintia orientalis.[Pubmed: 20334138]

    METHODS AND RESULTS:
    The new aristolactam alkaloid toussalactam {2-hydroxy-1,6-dimethoxy-5H-dibenzo[cdf]indol-4-one} and the known ones, namely aristolactam AII, Aristolactam BII, piperolactam C and aristolactam FII; 1-(2-C-methyl-beta-D-ribofuranosyl)-uracil, 3,4,5-trimethoxyphenyl-beta-D-glucopyranoside, and three catechinoids were isolated from the cytotoxic Toussaintia orientalis Verdc stem and root bark extracts, and their structures established based on analysis of spectroscopic data.
    CONCLUSIONS:
    The aristolactams exhibited antimicrobial and antiinflammatory activity, aristolactam FII showing almost the same level of activity as the standard anti-inflammatory agent Indomethacin. The compounds also exhibited either mild or no antiproliferative and cytotoxic activities, except aristolactam FII that showed the same level of cytotoxicity as the standard drug Camptothecin. 1-(2-C-Methyl-beta-D-ribofuranosyl)-uracil, which is being reported for the first time as a natural product, was inactive in the antibacterial, antifungal, antiinflammatory, antiproliferative and cytotoxicity assays.
    J. Appl. Pharm. Sci., 2014, 4(5):87-91.
    Antioxidant and Anti-tyrosinase Activities from Piper officinarum C.DC (Piperaceae).[Reference: WebLink]
    The present study was carried out to evaluate antioxidant and anti-tyrosinase activities from Piper officinarum stems, as well as investigation of its chemical constituents.
    METHODS AND RESULTS:
    In a series of in vitro assays, antioxidant (DPPH radical scavenging and total phenolic content) and anti-tyrosinase (mushroom tyrosinase) activities of various extracts of stem were evaluated. The isolation and purification of the constituents were carried out on the extracts using various chromatographic methods and identified by direct comparison of their spectroscopic data with respective published data. The results showed that the methanol extracts showed the highest DPPH (80.0%) at 1 mg/ml, as well as total phenolic content (50.5%). Phytochemical analysis of the stem extracts have isolated five compounds identified as 4-allyl resorcinol (1), aristolactam AII (2) Aristolactam BII (3), stigmast-4-en-3-one (4) and 6-hydroxystigmast-4-en-3-one (5). Compound (1), (2) and (3) showed significant activity towards DPPH radical scavenging (I%=17.3-28.1%), while (2), (3) and (4) demonstrated potent inhibitory effects against tyrosinase mushroom (I%=11.1-24.4%).
    CONCLUSIONS:
    The results showed that the stem extracts has significant antioxidant activity that may help to discover new chemical classes of natural antioxidant substances.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5804 mL 17.9019 mL 35.8038 mL 71.6076 mL 89.5095 mL
    5 mM 0.7161 mL 3.5804 mL 7.1608 mL 14.3215 mL 17.9019 mL
    10 mM 0.358 mL 1.7902 mL 3.5804 mL 7.1608 mL 8.9509 mL
    50 mM 0.0716 mL 0.358 mL 0.7161 mL 1.4322 mL 1.7902 mL
    100 mM 0.0358 mL 0.179 mL 0.358 mL 0.7161 mL 0.8951 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    马兜铃内酰胺FI; Aristolactam FI CFN99222 112501-42-5 C16H11NO3 = 265.3 5mg QQ客服:215959384
    马兜铃内酰胺AII; Aristolactam AII CFN96013 53948-07-5 C16H11NO3 = 265.3 5mg QQ客服:2056216494
    Griffithinam; Griffithinam CFN97866 240122-32-1 C17H13NO4 = 295.3 5mg QQ客服:2056216494
    马兜铃内酰胺II; Aristololactam II CFN91875 55610-00-9 C16H9NO3 = 263.25 5mg QQ客服:1457312923
    马兜铃内酰胺I; Aristololactam I CFN90312 13395-02-3 C17H11NO4 = 293.27 20mg QQ客服:2159513211
    马兜铃内酰胺A; 7-(2'-Deoxyadenosin-N6-yl)aristolactam I CFN90417 127191-86-0 C27H22N6O7 = 542.5 5mg QQ客服:2056216494
    马兜铃内酰胺AIIIa; Aristolactam AIIIa CFN97551 97399-91-2 C16H11NO4 = 281.3 5mg QQ客服:2159513211
    马兜铃内酰胺BII; Aristolactam BII CFN98903 53948-09-7 C17H13NO3 = 279.3 5mg QQ客服:2159513211
    马兜铃内酰胺BIII; Aristolactam BIII CFN98904 53948-10-0 C18H15NO4 = 309.3 5mg QQ客服:2159513211
    2-O-甲基马兜铃,胡椒内酰胺C; Piperolactam C CFN97948 116064-76-7 C18H15NO4 = 309.3 5mg QQ客服:3257982914

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