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  • 山小柑碱

    Arborinine

    山小柑碱
    产品编号 CFN89147
    CAS编号 5489-57-6
    分子式 = 分子量 C16H15NO4 = 285.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The fruits of Uapaca togoensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    山小柑碱 CFN89147 5489-57-6 1mg QQ客服:1413575084
    山小柑碱 CFN89147 5489-57-6 5mg QQ客服:1413575084
    山小柑碱 CFN89147 5489-57-6 10mg QQ客服:1413575084
    山小柑碱 CFN89147 5489-57-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Ioannina (Greece)
  • China Medical University (Taiwan)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Universidad Miguel Hernández (Spain)
  • Florida International University (USA)
  • Texas A&M University (USA)
  • University of Leipzig (Germany)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Shanghai University of TCM (China)
  • Tokyo Woman's Christian University (Japan)
  • Massachusetts General Hospital (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • Kyung Hee University (Korea)
  • University of Perugia (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Inflammation.2021, doi: 10.1007
  • J.Pharm. & Biome. Anal.2023, 2: 100018.
  • J Anal Toxicol.2021, bkab015.
  • Medicinal Chemistry Research 2021, 30:1117-1124.
  • Int Immunopharmacol.2022, 106:108603.
  • Chung Shan Medical University2020, US20200323790A1
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Pharmacol Res.2022, 182:106346.
  • Heinrich Heine University Dusseldorf2021, 62203.
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Int J Mol Sci.2020, 21(22):8816.
  • J Nat Med.2018, 72(3):734-744
  • Free Radic Biol Med.2016, 97:307-319
  • Phytother Res.2019, 33(7):1784-1793
  • Sci Rep.2018, 8:9267
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Phytochem Anal.2021, 32(6):970-981.
  • Spectrochim Acta A2019, 210:372-380
  • Phytother Res.2015, 29(7):1088-96
  • Mol Biol Rep.2022, doi: 10.1007
  • Lab Chip.2018, 18(6):971-978
  • China Pharmacy2015, 26(27)
  • PLoS One.2018, 13(4):e0195642
  • ...
  • 生物活性
    Description: Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC₅₀ values being 6.4 ± 0.7 ug/ml. Arborinine shows antifeedant activity against Spodoptera frugiperda. Arborinin shows cytotoxicity against nine drug sensitive and multidrug-resistant cancer cell lines, it also can strongly induce apoptosis in CCRF-CEM cells and cell cycle arrest in the G0/G1 and S phases.
    Targets: HCV | Antifection
    In vitro:
    Fitoterapia. 2014 Dec;99:276-83.
    Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves.[Pubmed: 25454460 ]

    METHODS AND RESULTS:
    We isolated six compounds, chalepin, scopoletin, γ-fagarine, Arborinine, kokusaginine and pseudane IX. Among them, chalepin and pseudane IX showed strong anti-HCV activities with 50% inhibitory concentration (IC₅₀) of 1.7 ± 0.5 and 1.4 ± 0.2 μg/ml, respectively, without apparent cytotoxicity. Their anti-HCV activities were stronger than that of ribavirin (2.8 ± 0.4 μg/ml), which has been widely used for the treatment of HCV infection.
    CONCLUSIONS:
    Mode-of-action analyses revealed that chalepin and pseudane IX inhibited HCV at the post-entry step and decreased the levels of HCV RNA replication and viral protein synthesis. We also observed that Arborinine, kokusaginine and γ-fagarine possessed moderate levels of anti-HCV activities with IC₅₀ values being 6.4 ± 0.7, 6.4 ± 1.6 and 20.4 ± 0.4 μg/ml, respectively, whereas scopoletin did not exert significant anti-HCV activities at 30 μg/ml.
    Fitoterapia. 2004 Jul;75(5):510-3.
    Antibacterial activity and cytotoxicity of extractives from Ravenia spectabilis.[Pubmed: 15261391 ]

    METHODS AND RESULTS:
    A methanolic extract of Ravenia spectabilis, an isolated alkaloid, arborinine plus a fraction comprising arborinine and gamma-fagarine (VLC), showed mild to significant in vitro antibacterial activity.
    CONCLUSIONS:
    In a brine shrimp lethality bioassay, the extract and the fraction were found to exhibit moderate cytotoxicity having LC50 of 76.26 microg/ml and 14.98 microg/ml, respectively.
    Fitoterapia. 2001 Jun;72(5):538-43.
    Antifeedant constituents from Fagara macrophylla.[Pubmed: 11429249]

    METHODS AND RESULTS:
    Analysis of the polar fractions of an EtOH extract obtained from the bark of the African medicinal plant Fagara macrophylla led to the isolation and identification of the alkaloids oblongine (6), tembetarine (7) and magnoflorine (8) and the flavonoid hesperidin (9). These compounds, together with other metabolites (1--5) previously isolated from F. macrophylla, were tested for antifeedant activity in a binary-choice bioassay. The acridone alkaloid xanthoxoline (4) was found to have a potent antifeedant activity against larvae of both Spodoptera frugiperda and S. littoralis.
    CONCLUSIONS:
    1-Hydroxy-3-methoxy-N-methyl-acridone (2), Arborinine (3), tembetarine (7) and magnoflorine (8) were antifeedant against S. frugiperda.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5052 mL 17.526 mL 35.0521 mL 70.1041 mL 87.6301 mL
    5 mM 0.701 mL 3.5052 mL 7.0104 mL 14.0208 mL 17.526 mL
    10 mM 0.3505 mL 1.7526 mL 3.5052 mL 7.0104 mL 8.763 mL
    50 mM 0.0701 mL 0.3505 mL 0.701 mL 1.4021 mL 1.7526 mL
    100 mM 0.0351 mL 0.1753 mL 0.3505 mL 0.701 mL 0.8763 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
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    Dorsmanin A; Dorsmanin A CFN96193 162229-27-8 C20H20O4 = 324.4 5mg QQ客服:215959384
    芹菜素-7-O-葡萄糖醛酸苷; Apigenin-7-glucuronide CFN98500 29741-09-1 C21H18O11 = 446.36 20mg QQ客服:1413575084
    Danaidone; Danaidone CFN00253 6064-85-3 C8H9NO = 135.16 5mg QQ客服:1457312923

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