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  • 阿彼斯基姆素,洋芫荽茵芋苷

    Apiosylskimmin

    阿彼斯基姆素,洋芫荽茵芋苷
    产品编号 CFN90311
    CAS编号 103529-94-8
    分子式 = 分子量 C20H24O12 = 456.40
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Peucedanum praeruptorum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    阿彼斯基姆素,洋芫荽茵芋苷 CFN90311 103529-94-8 1mg QQ客服:2056216494
    阿彼斯基姆素,洋芫荽茵芋苷 CFN90311 103529-94-8 5mg QQ客服:2056216494
    阿彼斯基姆素,洋芫荽茵芋苷 CFN90311 103529-94-8 10mg QQ客服:2056216494
    阿彼斯基姆素,洋芫荽茵芋苷 CFN90311 103529-94-8 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Illinois at Chicago (USA)
  • University Medical Center Mainz (Germany)
  • Siksha O Anusandhan University (India)
  • University of Oslo (Norway)
  • Universidade Católica Portuguesa (Portugal)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of Dicle (Turkey)
  • University of Toulouse (France)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Minnesota (USA)
  • Medical University of Gdansk (Poland)
  • University of Leipzig (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • LWT2021, 150:112021.
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • Microb Pathog.2019, 131:128-134
  • Sci Rep. 2018, 462(8)
  • Journal of Food Composition and Analysis2021, 100:103905.
  • Biomed Chromatogr.2020, e5021.
  • Appl. Sci.2023, 13(17), 9653.
  • Inflammation.2021, doi: 10.1007
  • Biomed Pharmacother.2023, 163:114785.
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Chem. of Vegetable Raw Materials2020, 97-105
  • Anticancer Res.2020, 40(10):5529-5538.
  • Food Chem.2019, 274:345-350
  • Biomimetics (Basel).2022, 7(4):154.
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • BMC Complement Altern Med.2014, 14:242
  • Process Biochemistry2019, 85:106-115
  • Horticulturae2021, 7(1),5.
  • Pharmacol Res.2020, 161:105205.
  • Exp Neurobiol.2018, 27(3):200-209
  • Molecules.2017, 22(12)
  • Spectrochim Acta A2019, 210:372-380
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • ...
  • 生物活性
    Description: Apiosylskimmin is a natural product from Angelica gigas.
    In vitro:
    Immunopharmacol Immunotoxicol. 2011 Dec;33(4):663-6.
    Antiplasmodial and cytotoxic activity of coumarin derivatives from dried roots of Angelica gigas Nakai in vitro.[Pubmed: 21428713]
    The butanol-soluble fraction of the dried root of Angelica gigas exhibited significant protection against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method.
    METHODS AND RESULTS:
    Using antiplasmodial activity-guided fractionation, five coumarins, marmesinin (1), nodakenin (2), skimmin (3), Apiosylskimmin (4), and magnolioside (5), were isolated and evaluated for in vitro antiplasmodial activity, as well as for their cytotoxic potential on SK-OV-3 cancer cell lines. Compounds 1 and 5 showed notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum with IC(50) values of 5.3 and 8.2 μM. The compounds showed no significant cytotoxicity (IC(50) > 100 μM) toward the SK-OV-3 cancer cell line.
    CONCLUSIONS:
    This is the first report on the antiplasmodial activity of these coumarin derivatives from the dried root of A. gigas.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1911 mL 10.9553 mL 21.9106 mL 43.8212 mL 54.7765 mL
    5 mM 0.4382 mL 2.1911 mL 4.3821 mL 8.7642 mL 10.9553 mL
    10 mM 0.2191 mL 1.0955 mL 2.1911 mL 4.3821 mL 5.4777 mL
    50 mM 0.0438 mL 0.2191 mL 0.4382 mL 0.8764 mL 1.0955 mL
    100 mM 0.0219 mL 0.1096 mL 0.2191 mL 0.4382 mL 0.5478 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    阿彼斯基姆素,洋芫荽茵芋苷; Apiosylskimmin CFN90311 103529-94-8 C20H24O12 = 456.40 10mg QQ客服:2159513211
    伞形花内酯-7-O-芸香糖苷; Umbelliferone 7-O-rutinoside CFN95431 135064-04-9 C21H26O12 = 470.4 10mg QQ客服:3257982914
    7-异戊烯氧基香豆素; 7-Prenylumbelliferone CFN90825 10387-50-5 C14H14O3 = 230.3 20mg QQ客服:2056216494
    橙皮油内酯; Auraptene CFN98787 495-02-3 C19H22O3 = 298.4 20mg QQ客服:1413575084
    Marmin; Marmin CFN99621 14957-38-1 C19H24O5 = 332.4 20mg QQ客服:1457312923
    Marmin acetonide; Marmin acetonide CFN98408 320624-68-8 C22H28O5 = 372.5 5mg QQ客服:2159513211
    7'-O-Ethylmarmin; 7'-O-Ethylmarmin CFN97584 N/A C21H28O5 = 360.5 5mg QQ客服:2159513211
    Excavatin M; Excavatin M CFN98274 250293-31-3 C19H20O7 = 360.4 5mg QQ客服:2056216494
    Diversoside; Diversoside CFN89254 55062-36-7 C25H34O10 = 494.53 10mg QQ客服:2159513211
    香豆素; Coumarin CFN99552 91-64-5 C9H6O2 = 146.15 20mg QQ客服:3257982914

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