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  • 安五脂素

    Anwulignan

    安五脂素
    产品编号 CFN98539
    CAS编号 107534-93-0
    分子式 = 分子量 C20H24O4 = 328.41
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Schisandra sphenanthera.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    安五脂素 CFN98539 107534-93-0 10mg QQ客服:215959384
    安五脂素 CFN98539 107534-93-0 20mg QQ客服:215959384
    安五脂素 CFN98539 107534-93-0 50mg QQ客服:215959384
    安五脂素 CFN98539 107534-93-0 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Malaysia Pahang (Malaysia)
  • Charles Sturt University (Denmark)
  • Medical University of Gdansk (Poland)
  • Celltrion Chemical Research Institute (Korea)
  • John Innes Centre (United Kingdom)
  • Cornell University (USA)
  • Universiti Sains Malaysia (Malaysia)
  • Yale University (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Harvard University (USA)
  • Florida A&M University (USA)
  • University of Minnesota (USA)
  • Agricultural Research Organization (ARO) (Israel)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Heliyon.2022, 8(12):e12031.
  • Molecules2022, 27(9):2827.
  • Front Pharmacol.2019, 10:1025
  • Front Cell Dev Biol.2021, 9:638174.
  • Agriculture.2022, 12(3), 342.
  • BMC Complement Med Ther. 2020, 20(1):94.
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • J Ethnopharmacol.2017, 206:327-336
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Int J Mol Sci.2019, 20(14):E3538
  • Oxid Med Cell Longev2020, 12
  • J Biochem Mol Toxicol.2022, e23211.
  • Separations2023, 10(11), 567;
  • Phytother Res.2022, 10.1002:ptr.7592.
  • Heliyon.2023, e12778.
  • J Cell Biochem.2022, 123(7):1222-1236.
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • J-STAGE2015, 249-255
  • Inflammation.2020, 43(5):1716-1728.
  • Food Chem.2019, 290:286-294
  • Appl. Sci.2023, 13(17), 9653.
  • Phytochem Anal.2016, 27(5):296-303
  • ...
  • 生物活性
    Description: Anwuligan has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities. (+)-Anwulignan has inhibitory effects on platelets aggregation induced by adenosine diphosphate (ADP) and platelet activating factor(PAF) in vitro.
    Targets: PAFR | Antifection
    In vitro:
    Journal of Shanghai Medica, 2005, 32(4):467-70.
    Effects of heteroclitin D, schisanhenol and ( + )-anwulignan on platelet aggregation.[Reference: WebLink]
    To investigate the effects of three lignans: heteroclitin D (HD), schisanhenol (SAL) and ( + )-Anwulignan(AN) with different skeletons from Schisandraceae medicinal plants on platelet aggregation.
    METHODS AND RESULTS:
    At concentrations 0.05-25 mg/L of the three lignans, rabbit platelet aggregation induced by adenosine diphosphate (ADP) and platelet activating factor(PAF) were studied by Born's turbidimetry, the maximum time of platelet aggregation and platelet aggregation at 1,3,5 min were also observed. 1 HD and SAL inhibited the ADP- and PAF-induced platelet aggregation in a concentration-dependant manner. The inhibitory effect of AN was weak. 2 ADP-induced platelet aggregation at 1, 3,5 min were inhibited by HD and SAL in a similar manner. At 5 mg/L,AN inhibited platelet aggregation at 3 and 5 min significantly;The PAF-induced platelet aggregation at 1,3,5 min, the inhibition of HD at 1,3 min and of SAL at 3,5 min were more potent. 3 HD, SAL and AN had no effects on maximum time of ADP- and PAF-induced platelet aggregation.
    CONCLUSIONS:
    HD,SAL and AN have inhibitory effects on platelets aggregation induced by ADP and PAF in vitro. The inhibitory effect of HD is the most potent and could be one of the important active components from Kadsura medicinal plants.
    In vivo:
    Chin Med . 2011 Mar 4;6:10.
    Effects of a multi-herbal extract on type 2 diabetes[Pubmed: 21375727]
    Abstract Background: An aqueous extract of multi-hypoglycemic herbs of Panax ginseng C.A.Meyer, Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus and Evodia officinalis was investigated for its anti-diabetic effects in cell and animal models. Methods: Activities of PPARγ agonist, anti-inflammation, AMPK activator and anti-ER stress were measured in cell models and in db/db mice (a genetic animal model for type 2 diabetes). Results: While the extract stimulated PPARγ-dependent luciferase activity and activated AMPK in C2C12 cells, it inhibited TNF-α-stimulated IKKβ/NFkB signaling and attenuated ER stress in HepG2 cells. The db/db mice treated with the extract showed reduced fasting blood glucose and HbA1c levels, improved postprandial glucose levels, enhanced insulin sensitivity and significantly decreased plasma free fatty acid, triglyceride and total cholesterol. Conclusion: The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.045 mL 15.2249 mL 30.4497 mL 60.8995 mL 76.1244 mL
    5 mM 0.609 mL 3.045 mL 6.0899 mL 12.1799 mL 15.2249 mL
    10 mM 0.3045 mL 1.5225 mL 3.045 mL 6.0899 mL 7.6124 mL
    50 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
    100 mM 0.0304 mL 0.1522 mL 0.3045 mL 0.609 mL 0.7612 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二氢愈创木脂酸; Dihydroguaiaretic acid CFN97133 66322-34-7 C20H26O4 = 330.4 10mg QQ客服:2056216494
    安五脂素; Anwulignan CFN98539 107534-93-0 C20H24O4 = 328.41 20mg QQ客服:2056216494
    赤式-6-澳白木脂素; erythro-Austrobailignan-6 CFN95501 114127-24-1 C20H24O4 = 328.4 10mg QQ客服:215959384
    Schineolignin B; Schineolignin B CFN92717 1352185-26-2 C22H30O5 = 374.5 5mg QQ客服:215959384
    华中五脂素; Sphenanlignan CFN95245 866347-36-6 C21H26O5 = 358.4 5mg QQ客服:1413575084
    Arisanschinin E; Arisanschinin E CFN95221 1333378-33-8 C21H28O5 = 360.5 5mg QQ客服:2056216494
    前五味子脂素; Pregomisin CFN96694 66280-26-0 C22H30O6 = 390.47 10mg QQ客服:2056216494
    脱水开环异落叶松树脂酚; Anhydrosecoisolariciresinol CFN89236 29388-33-8 C20H24O5 = 344.40 5mg QQ客服:1413575084
    4,4'-[[(2S,3S,4S)-四氢-2-甲氧基-3,4-呋喃二基]二(亚甲基)]二[2-甲氧基苯酚]; 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan CFN96711 1206464-65-4 C21H26O6 = 374.43 5mg QQ客服:2056216494
    开环异落叶松树脂酚; Secoisolariciresinol CFN98363 29388-59-8 C20H26O6 = 362.4 10mg QQ客服:1457312923

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