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  • 安格洛苷C; 安格洛甙C

    Angoroside C

    安格洛苷C; 安格洛甙C
    产品编号 CFN98149
    CAS编号 115909-22-3
    分子式 = 分子量 C36H48O19 = 784.75
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Scrophularia ningpoensis Hemsl.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    安格洛苷C; 安格洛甙C CFN98149 115909-22-3 10mg QQ客服:2056216494
    安格洛苷C; 安格洛甙C CFN98149 115909-22-3 20mg QQ客服:2056216494
    安格洛苷C; 安格洛甙C CFN98149 115909-22-3 50mg QQ客服:2056216494
    安格洛苷C; 安格洛甙C CFN98149 115909-22-3 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universite Libre de Bruxelles (Belgium)
  • University of Virginia (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Biotech R&D Institute (USA)
  • University of Indonesia (Indonesia)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • University of Toulouse (France)
  • Korea Food Research Institute(KFRI) (Korea)
  • Monash University Sunway Campus (Malaysia)
  • Periyar University (India)
  • University of Perugia (Italy)
  • University of Pretoria (South Africa)
  • Agricultural Research Organization (ARO) (Israel)
  • Donald Danforth Plant Science Center (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plants (Basel).2021, 10(2):278.
  • Biomed Pharmacother.2023, 166:115329.
  • Sci Rep.2019, 9:19059
  • Phytochemistry Letters2017, 449-455
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • J Ethnopharmacol.2022, 289:115018.
  • Molecules.2020, 25(9):2081.
  • Int Immunopharmacol. 2020, 83:106403.
  • Natural Product Communications2020, doi: 10.1177.
  • Industrial Food Engineering2015, 19(4):408-413
  • Oxid Med Cell Longev.2022, 2022:9139338.
  • Front Microbiol.2020, 11:583594.
  • Int J Mol Sci.2021, 22(21):11447.
  • J Appl Biol Chem.2021, 64(3),263?268
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Int J Mol Sci.2020, 21(9):3144.
  • Molecules.2020, 25(18):4283.
  • Molecules.2019, 24(2):E343
  • Life Sci.2019, 216:259-270
  • J Cell Mol Med.2023, jcmm.18071.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Molecules.2021, 26(3):695.
  • ...
  • 生物活性
    Description: Angoroside C has anti-inflammatory effect , it can significantly inhibit LPS-induced PGE(2), NO and TNF-alpha in a concentration-dependent manner; it also exhibits cytotoxic and cytostatic activities against several kinds of cancer cells. Angoroside C has beneficial effects against ventricular remodeling, the mechanism is likely to be related to decreasing the level of Ang Ⅱ, attenuating the mRNA expressions of ET-1 and TGF-β1.
    Targets: COX | LOX | NO | TNF-α | PGE | MMP(e.g.TIMP) | TGF-β/Smad
    In vitro:
    Life Sci. 2004 Apr 2;74(20):2515-26.
    Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity.[Pubmed: 15010262]
    Five phenylpropanoid glycosides isolated from Scrophularia scorodonia L. (Scrophulariaceae), namely angoroside A (1), angoroside C (2), angoroside D (3), acteoside (4) and isoacteoside (5), had been evaluated as potential inhibitors of some macrophage functions involved in the inflammatory process.
    METHODS AND RESULTS:
    These compounds have been tested in two experimental systems: ionophore-stimulated mouse peritoneal macrophages and human platelets serve as source of COX-1 and 5-LOX, and mouse peritoneal macrophages stimulated with E. coli LPS are the means of testing for COX-2, NO and TNF-alpha activity. None of compounds assayed had a significant effect on LTC(4)-release from calcium ionophore-stimulated mouse peritoneal macrophages. However, the release of PGE(2) by mouse peritoneal macrophages stimulated with calcium ionophore was inhibited by most of these compounds. In the TXB(2)-release assay, acteoside (4), angoroside A (1) and angoroside C (2) showed a significant effect. These five compounds, except angoroside C (2) significantly inhibited LPS-induced PGE(2), NO and TNF-alpha in a concentration-dependent manner. In LPS-stimulated macrophages, the phenylpropanoid glycoside angoroside C (2) only had activity on NO.
    CONCLUSIONS:
    These results indicate that the pharmacology of these compounds may participate in the anti-inflammatory effect of Scrophularia scorodonia.
    In vivo:
    Phytomedicine. 2015 Jul 15;22(7-8):705-12.
    The effect of angoroside C on pressure overload-induced ventricular remodeling in rats.[Pubmed: 26141756 ]
    Our previous study reveals that total rough extract of Radix Scrophulariae has a beneficial effect on ventricular remodeling. HYPOTHESIS: After carrying out a series of preliminary experiments, we speculated that angoroside C may be the effective agent. STUDY DESIGN: After oral administration, the effect of angoroside C on ventricular remodeling was evaluated by using a pressure-overloaded rat model, some related indexes were detected in vivo.
    METHODS AND RESULTS:
    A model of pressure overloaded ventricular remodeling was produced by abdominal aortic constriction (AAC) in rats. The sham-operated rats underwent an identical surgical procedure except for AAC. AAC rats were randomly divided into five groups: model control group, three angoroside C treated groups (7.5, 15 and 30 mg·kg(-1)) and captopril treated group (40 mg·kg(-1)). The rats were orally administered with the corresponding drugs or drinking water for 4 weeks. The levels of blood pressure (BP), left ventricular weight index (LVWI) and heart weight index (HWI) were detected. Myocardium tissue was stained with hematoxylin and eosin or picric acid/sirius red for cardiomyocyte cross-section area or collagen content measurements respectively. The concentrations of angiotensin Ⅱ (Ang Ⅱ), hydroxyproline (Hyp), matrix metalloproteinase 2 (MMP-2), MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in myocardium or serum were determined. Real-time RT-PCR was performed to detect the mRNA expressions of endothelin 1 (ET-1), transforming growth factor β1 (TGF-β1). Angoroside C significantly reduced the BP, LVWI and HWI, decreased the content of Ang Ⅱ, Hyp, diminished cross sectional area of cardiomyocytes and ameliorated collagen deposition. Additionally, it markedly reduced collagen I and III expressions and regulated matrix metalloproteinase-2, 9 and inhibitors of metalloproteinase expressions. Angoroside C also down regulated the gene expressions of ET-1 and TGF-β1mRNA in myocardium.
    CONCLUSIONS:
    Angoroside C has beneficial effects against ventricular remodeling. The mechanism is likely to be related to decreasing the level of Ang Ⅱ, attenuating the mRNA expressions of ET-1 and TGF-β1.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2743 mL 6.3715 mL 12.7429 mL 25.4858 mL 31.8573 mL
    5 mM 0.2549 mL 1.2743 mL 2.5486 mL 5.0972 mL 6.3715 mL
    10 mM 0.1274 mL 0.6371 mL 1.2743 mL 2.5486 mL 3.1857 mL
    50 mM 0.0255 mL 0.1274 mL 0.2549 mL 0.5097 mL 0.6371 mL
    100 mM 0.0127 mL 0.0637 mL 0.1274 mL 0.2549 mL 0.3186 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    西伯利亚远志糖A1; Sibiricose A1 CFN91841 139726-40-2 C23H32O15 = 548.5 5mg QQ客服:1457312923
    6-O-咖啡酰基熊果甙; 6-O-Caffeoylarbutin CFN99427 136172-60-6 C21H22O10 = 434.4 5mg QQ客服:1413575084
    灯盏花苷 I; Erigeside I CFN96865 224824-74-2 C20H20O11 = 436.36 5mg QQ客服:215959384
    木通苯乙醇苷B; Calceolarioside B CFN90647 105471-98-5 C23H26O11 = 478.45 20mg QQ客服:1457312923
    木通苯乙醇苷A; Calceolarioside A CFN98522 84744-28-5 C23H26O11 = 478.44 5mg QQ客服:215959384
    去鼠李糖地黄苷; Desrhamnosylmartynoside CFN89370 136055-64-6 C25H30O11 = 506.49 5mg QQ客服:2056216494
    管花肉苁蓉苷B1; Cistantubuloside B1 CFN95714 130009-44-8 C35H46O19 = 770.7 5mg QQ客服:2159513211
    连翘酯苷B; Forsythoside B CFN99715 81525-13-5 C34H44O19 = 756.70 20mg QQ客服:2159513211
    金石蚕苷; Poliumoside CFN99714 94079-81-9 C35H46O19 = 770.73 20mg QQ客服:1457312923
    2'-乙酰基金石蚕苷; Brandioside CFN90882 133393-81-4 C37H48O20 = 812.8 10mg QQ客服:1413575084

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