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  • 蛇葡萄素; 二氢杨梅素

    Ampelopsin

    蛇葡萄素; 二氢杨梅素
    产品编号 CFN98326
    CAS编号 27200-12-0
    分子式 = 分子量 C15H12O8 = 320.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Myrica rubra (Lour.) Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蛇葡萄素; 二氢杨梅素 CFN98326 27200-12-0 10mg QQ客服:1457312923
    蛇葡萄素; 二氢杨梅素 CFN98326 27200-12-0 20mg QQ客服:1457312923
    蛇葡萄素; 二氢杨梅素 CFN98326 27200-12-0 50mg QQ客服:1457312923
    蛇葡萄素; 二氢杨梅素 CFN98326 27200-12-0 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mahatma Gandhi University (India)
  • University of Amsterdam (Netherlands)
  • Monash University Malaysia (Malaysia)
  • University of Madras (India)
  • Kyoto University (Japan)
  • University of Vienna (Austria)
  • Technical University of Denmark (Denmark)
  • Utrecht University (Netherlands)
  • University of Malaya (Malaysia)
  • Stanford University (USA)
  • Harvard University (USA)
  • Griffith University (Australia)
  • MTT Agrifood Research Finland (Finland)
  • Lodz University of Technology (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Arch Biochem Biophys.2020, 687:108384.
  • J of Apicultural Research2020, 10.1080
  • Front Pharmacol.2020, 11:683.
  • J Nat Prod.2021, 84(9):2544-2553.
  • Phytochemistry Letters2015, 243-247
  • BMB Rep.2020, 53(4):218-222.
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Int J Mol Sci.2020, 21(6):2190.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • Int Immunopharmacol.2019, 71:361-371
  • Evid Based Complement Alternat Med.2021, 2021:8850744.
  • J Biomol Struct Dyn.2022, 1-21.
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • J Ethnopharmacol.2020, 260:112988.
  • Molecules.2019, 24(10):E1926
  • Biomedicines.2021, 9(8):996.
  • J Food Sci Technol.2022, 59(1):212-219.
  • Front Microbiol.2020, 11:583594.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • Tea Res. Ins. Of China2017, 1-12
  • Curr Eye Res.2018, 43(1):27-34
  • Chemistry of Natural Compounds2018, 204-206
  • ...
  • 生物活性
    Description: Ampelopsin,a major antifungal constituent from Salix sachalinensis, which has hepatoprotective, anti-inflammatory,antioxidant, antitumor, anti-invasive and anti-metastatic effects. It is an effective mTOR inhibitor, it inhibited the interconnected ROS/Akt/IKK/NF-κB signaling pathways, and it inhibited H₂O₂-induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme oxygenase-1.
    Targets: TNF-α | IL Receptor | NO | NF-kB | NOS | Akt | PI3K | IkB | MAPK | ROS | Bcl-2/Bax | Caspase | ROS | HO-1 | ERK | mTOR | P-gp | Antifection | IKK
    In vitro:
    Int Immunopharmacol. 2012 Jan;12(1):278-87.
    Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.[Pubmed: 22193240 ]
    Ampelopsin (AMP), a plant flavonoid, has potent anti-inflammatory properties in vitro and in vivo. The molecular mechanisms of ampelopsin on pharmacological and biochemical actions of RAW264.7 macrophages in inflammation have not been clearly elucidated yet.
    METHODS AND RESULTS:
    In the present study, non-cytotoxic level of ampelopsin significantly inhibited the release of nitric oxide (NO) and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in a dose-dependent manner. Consistent with NO inhibition, ampelopsin suppressed lipopolysaccharide (LPS)-induced expression of inducible NO synthase (iNOS) by inhibiting nuclear factor κB (NF-κB) activation, which highly correlated with its inhibitory effect on IκB kinase (IKK) phosphorylation, IκB phosphorylation and NF-κB nuclear translocation. Further study demonstrated that ampelopsin suppressed LPS-induced activation of Akt without effecting mitogen-activated protein kinases (MAPKs) phosphorylation. A pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, abrogated IKK/IκB/NF-κB-mediated iNOS gene expression. Finally, we certificated that ampelopsin reduced reactive oxygen species (ROS) accumulation and an anti-oxidant N-acetyl-L-cysteine (NAC) significantly repressed LPS-induced PI3K/Akt phosphorylation and the downstream IKK/IκB activation. NAC thereby inhibited LPS-induced iNOS expression and NO production.
    CONCLUSIONS:
    The present results suggest that the anti-inflammatory effect of ampelopsin is due to inhibiting the interconnected ROS/Akt/IKK/NF-κB signaling pathways.
    Journal of the Agricultural Chemical Society of Japan, 2001, 75(6):659-67.
    Ampelopsin, a Major Antifungla Constitutent from Salix sachalinensis, and its Methyl Ethers.[Reference: WebLink]

    METHODS AND RESULTS:
    To measure the antifungal potency of plant secondary metabolites, we did an antifungal test using Cladosporium herbarum as a test fungus and minute extracts of some plants. This test showed that the methanol extract of Salix sachalinensis leaves had strong antifungal activity. An antifugal principle in the leaves has been identified as (2R,3R)-(+)-5,7,3 ' ,4 ' ,5 ' -pentahydroxy-dihydroflavonol (ampelopsin). The antifungal potency of S. sachalinensis leaves was not due to an antifungal constituent with high specific activity, but due to the high content of ampelopsin.
    CONCLUSIONS:
    To improve the antifungal activity, ampelopsin was made into variously methylated derivatives, and these products were bioassayed. 7,3 ' ,4 ' -Tri-O-methylampelopsin, out of 8 derivatives, had the strongest antifungal activity, which was about 4 times that of ampelopsin. The structure-activity relationship is briefly discussed.
    PLoS One . 2015 May 19;10(5):e0127634.
    Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases[Pubmed: 25993634]
    Abstract Dihydropyrimidinase is a member of the cyclic amidohydrolase family, which also includes allantoinase, dihydroorotase, hydantoinase, and imidase. These metalloenzymes possess very similar active sites and may use a similar mechanism for catalysis. However, whether the substrates and inhibitors of other cyclic amidohydrolases can inhibit dihydropyrimidinase remains unclear. This study investigated the inhibition of dihydropyrimidinase by flavonoids and substrates of other cyclic amidohydrolases. Allantoin, dihydroorotate, 5-hydantoin acetic acid, acetohydroxamate, orotic acid, and 3-amino-1,2,4-triazole could slightly inhibit dihydropyrimidinase, and the IC50 values of these compounds were within the millimolar range. The inhibition of dihydropyrimidinase by flavonoids, such as myricetin, quercetin, kaempferol, galangin, dihydromyricetin, and myricitrin, was also investigated. Some of these compounds are known as inhibitors of allantoinase and dihydroorotase. Although the inhibitory effects of these flavonoids on dihydropyrimidinase were substrate-dependent, dihydromyricetin significantly inhibited dihydropyrimidinase with IC50 values of 48 and 40 μM for the substrates dihydrouracil and 5-propyl-hydantoin, respectively. The results from the Lineweaver-Burk plot indicated that dihydromyricetin was a competitive inhibitor. Results from fluorescence quenching analysis indicated that dihydromyricetin could form a stable complex with dihydropyrimidinase with the K(d) value of 22.6 μM. A structural study using PatchDock showed that dihydromyricetin was docked in the active site pocket of dihydropyrimidinase, which was consistent with the findings from kinetic and fluorescence studies. This study was the first to demonstrate that naturally occurring product dihydromyricetin inhibited dihydropyrimidinase, even more than the substrate analogs (>3 orders of magnitude). These flavonols, particularly myricetin, may serve as drug leads and dirty drugs (for multiple targets) for designing compounds that target several cyclic amidohydrolases.
    In vivo:
    Biofactors. 2004;21(1-4):175-8.
    Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin.[Pubmed: 15630194]

    METHODS AND RESULTS:
    Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, alpha-tocopherol levels and GSG/GSSH caused by GalN treatment.
    CONCLUSIONS:
    These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.
    Carcinogenesis. 2014 Aug;35(8):1847-54.
    Ampelopsin suppresses breast carcinogenesis by inhibiting the mTOR signalling pathway.[Pubmed: 24861637]
    The mammalian target of rapamycin (mTOR), which is a master regulator of cellular catabolism and anabolism, plays an important role in tumourigenesis and progression.
    METHODS AND RESULTS:
    In this study, we report the chemopreventive effect of the dietary compound ampelopsin (AMP) on breast carcinogenesis in vivo and in vitro, which acts by inhibiting the mTOR signalling pathway. Our study indicates that AMP treatment effectively suppresses 1-methyl-1-nitrosourea (MNU)-induced breast carcinogenesis in rats and inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P)-induced cellular carcinogenesis. Additionally, AMP inhibits the growth of breast cancer cells in vitro and in vivo. The activity of mTOR kinase was found to be significantly increased in a time-dependent manner during chronic breast carcinogenesis, and this increase can be suppressed by AMP co-treatment. AMP also effectively suppresses mTOR activity in breast cancer MDA-MB-231 cells. We also demonstrated that AMP is an effective mTOR inhibitor that binds to one site on the mTOR target in two ways. Further studies confirmed that AMP inhibits the activation of Akt, suppresses the formation of mTOR complexes (mTORC)1/2 by dissociating regulatory-associated protein of mTOR and rapamycin-insensitive companion of mTOR and, consequently, decreases the activation of the downstream targets of mTOR, including ribosomal p70-S6 kinase, ribosomal protein S6, eukaryotic translation initiation factor 4B and eukaryotic translation initiation factor 4E-binding protein 1.
    CONCLUSIONS:
    These finding suggest that AMP is a bioactive natural chemopreventive agent against breast carcinogenesis and is an effective mTOR inhibitor that may be developed as a useful chemotherapeutic agent in the treatment of breast cancer.
    Oncotarget . 2016 Nov 15;7(46):74484-74495.
    Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway[Pubmed: 27780933]
    Abstract The underlying molecular mechanisms for aging-related neurodegenerative diseases such as Alzheimer's disease (AD) are not fully understood. Currently, growing evidences have revealed that microRNAs (miRNAs) are involved in aging and aging-related diseases. The up-regulation of miR-34a has been reported to be associated with aging-related diseases, and thus it should be a promising therapeutic target. Ampelopsin, also called dihydromyricetin (DHM), a natural flavonoid from Chinese herb Ampelopsis grossedentata, has been reported to possess multiple pharmacological functions including anti-inflammatory, anti-oxidative and anti-cancer functions. Meanwhile, it has also gained tremendous attention against neurodegenerative diseases as an anti-aging compound. In the present study, the model rats with D-gal-induced brain aging revealed an obvious expression of miR-34a; in contrast, it could be significantly suppressed upon DHM treatment. In addition, target genes associated with miR-34a in the presence of DHM treatment were also explored. DHM supplementation inhibited D-gal-induced apoptosis and rescued impaired autophagy of neurons in hippocampus tissue. Moreover, DHM activated autophagy through up-regulated SIRT1 and down-regulated mTOR signal pathways due to the down-regulated miR-34a. In conclusion, DHM can execute the prevention and treatment of D-gal-induced brain aging by miR-34a-mediated SIRT1-mTOR signal pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1221 mL 15.6104 mL 31.2207 mL 62.4415 mL 78.0518 mL
    5 mM 0.6244 mL 3.1221 mL 6.2441 mL 12.4883 mL 15.6104 mL
    10 mM 0.3122 mL 1.561 mL 3.1221 mL 6.2441 mL 7.8052 mL
    50 mM 0.0624 mL 0.3122 mL 0.6244 mL 1.2488 mL 1.561 mL
    100 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.6244 mL 0.7805 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    花旗松素; Taxifolin CFN98734 480-18-2 C15H12O7 = 304.3 20mg QQ客服:2159513211
    李属素; Padmatin CFN97280 80453-44-7 C16H14O7 = 318.3 5mg QQ客服:1457312923
    雪松素 ; Deodarin CFN96563 33788-39-5 C16H14O7 = 318.29 5mg QQ客服:1457312923
    2',3,5,6',7-四羟基二氢黄烷酮; 2',3,5,6',7-Pentahydroxyflavanone CFN97277 80366-15-0 C15H12O7 = 304.3 5mg QQ客服:3257982914
    二氢桑色素; Dihydromorin CFN99854 18422-83-8 C15H12O7 = 304.3 5mg QQ客服:2056216494
    二氢柽柳黄素; Dihydrotamarixetin CFN97194 70411-27-7 C16H14O7 = 318.3 5mg QQ客服:3257982914
    艾纳香素B; Blumeatin B CFN97274 79995-67-8 C17H16O7 = 332.3 5mg QQ客服:215959384
    刺槐亭; Dihydrorobinetin CFN98671 4382-33-6 C15H12O7 = 304.3 5mg QQ客服:2159513211
    蛇葡萄素; 二氢杨梅素; Ampelopsin CFN98326 27200-12-0 C15H12O8 = 320.3 20mg QQ客服:215959384
    Sepinol; Sepinol CFN97204 72061-63-3 C16H14O7 = 318.3 5mg QQ客服:2159513211

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