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  • 1,2-二羟基蒽醌,茜素

    Alizarin

    1,2-二羟基蒽醌,茜素
    产品编号 CFN92568
    CAS编号 72-48-0
    分子式 = 分子量 C14H8O4 = 240.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Anthraquinones
    植物来源 The roots of Rubia cordifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1,2-二羟基蒽醌,茜素 CFN92568 72-48-0 10mg QQ客服:2159513211
    1,2-二羟基蒽醌,茜素 CFN92568 72-48-0 20mg QQ客服:2159513211
    1,2-二羟基蒽醌,茜素 CFN92568 72-48-0 50mg QQ客服:2159513211
    1,2-二羟基蒽醌,茜素 CFN92568 72-48-0 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Canterbury (New Zealand)
  • University Medical Center Mainz (Germany)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Utrecht University (Netherlands)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Anna University (India)
  • Tohoku University (Japan)
  • Kyushu University (Japan)
  • Sri Ramachandra University (India)
  • University of Ioannina (Greece)
  • University of Indonesia (Indonesia)
  • Sant Gadge Baba Amravati University (India)
  • University of Illinois at Chicago (USA)
  • University of Hawaii Cancer Center (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pest Manag Sci.2019, 75(9):2530-2541
  • Neurotoxicology.2022, 91:218-227.
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • Front Plant Sci.2023, 14:1207940.
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Mol Cells.2018, 41(8):771-780
  • J Agric Food Chem.2020, 68(51):15164-15175
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • J Agric Food Chem.2018, 66(1):351-358
  • Plants2022, 11(3),294.
  • Neurotox Res.2022, 40(6):1937-1947.
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • Molecules.2021, 26(9):2526.
  • Int J Mol Sci.2019, 20(23):E6071
  • Semyung University2017, 149407
  • BMC Complement Altern Med.2014, 14:242
  • Pharmacol Rep.2017, 69(6):1224-1231
  • J Am Soc Mass Spectrom.2021, 32(5):1205-1214.
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Food Funct.2021, 12(13):5892-5902.
  • Nutrients.2017, 10(1)
  • Food Chem.2016, 191:81-90
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • ...
  • 生物活性
    Description: Alizarin has a selective and effective inhibitory activity towards cancerous cells, it acts through the inhibition of ERK phosphorylation and cell cycle arrest in the S-phase. Alizarin has antigenotoxic activity, which can be explained by inhibition of CYP activities responsible for activating the mutagens.
    Targets: ERK | P450 (e.g. CYP17) | NADPH-oxidase
    In vitro:
    J Orthop Res. 2012 Sep;30(9):1486-92.
    The natural compound Alizarin as an osteotropic drug for the treatment of bone tumors.[Pubmed: 22411621]
    Despite significant clinical improvements, conventional therapies for bone cancer treatment are limited by significant systemic toxicity and lack of specific targeting. In this study, we considered Alizarin, a natural hydroxyanthraquinone derived from madder root with high affinity to calcium and remarkable osteotropic features, as a novel approach for bone cancer treatment. Due to its antitumor properties, as demostrated in colon cancer cells, and to its tropism to bone, Alizarin may be an ideal drug to reduce bone tumor growth.
    METHODS AND RESULTS:
    We demonstrated that low dosages of Alizarin strongly inhibited the osteosarcoma (IC(50) for Saos-2, MG-63, and U-2 OS cells, 27.5, 29.0, and 69.9 µg/ml, respectively) and breast carcinoma (IC(50) for MDA-MB-231 cells, 62.1 µg/ml) cell proliferation in vitro. Importantly, Alizarin had a significantly lower inhibitory activity on normal cells (IC(50) for MSC, 828.6 µg/ml), thereby revealing a selective activity towards malignant cells. Furthermore, we found that Alizarin acted through the inhibition of ERK phosphorylation and cell cycle arrest in the S-phase. Finally, Alizarin significantly and strongly impaired both osteosarcoma and breast cancer tumorigenesis.
    CONCLUSIONS:
    Our results highlight a selective and effective inhibitory activity of Alizarin towards cancerous cells, laying the basis for further studies to investigate its application in bone cancer therapy.
    J Phys Chem B . 2017 Apr 27;121(16):4129-4136.
    Ultrafast Intramolecular Proton Transfer of Alizarin Investigated by Femtosecond Stimulated Raman Spectroscopy[Pubmed: 28375609]
    Abstract We report time-resolved stimulated Raman spectra of alizarin in DMSO solution with 403 nm excitation. Upon photoexcitation, the intramolecular proton transfer reaction of alizarin occurs in 70-80 fs, which is confirmed by both the population growth and the frequency and bandwidth changes of skeletal vibrational modes of alizarin. Interestingly, the vibrational frequencies of ν(C═C) and ν(C═O) show opposite shifts during the reaction, which may implicate changes in the resonance structure of anthraquinone and the attached carbonyl group. Vibrational relaxation in the potential surface of the proton transferred tautomer of alizarin and the population decay occurring with two distinct time scales were also observed in addition to the solvation dynamics of DMSO solvent molecules.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1632 mL 20.816 mL 41.632 mL 83.2639 mL 104.0799 mL
    5 mM 0.8326 mL 4.1632 mL 8.3264 mL 16.6528 mL 20.816 mL
    10 mM 0.4163 mL 2.0816 mL 4.1632 mL 8.3264 mL 10.408 mL
    50 mM 0.0833 mL 0.4163 mL 0.8326 mL 1.6653 mL 2.0816 mL
    100 mM 0.0416 mL 0.2082 mL 0.4163 mL 0.8326 mL 1.0408 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1,2-二羟基蒽醌,茜素; Alizarin CFN92568 72-48-0 C14H8O4 = 240.2 20mg QQ客服:1413575084
    茜素-1-甲醚; 2-Hydroxy-1-methoxyanthraquinone CFN92111 6170-06-5 C15H10O4 = 254.2 10mg QQ客服:215959384
    1-羟基-2-甲氧基蒽醌; Alizarin 2-methyl ether CFN92569 6003-11-8 C15H10O4 = 254.2 5mg QQ客服:215959384
    异茜草素; Xanthopurpurin CFN96430 518-83-2 C14H8O4 = 240.21 5mg QQ客服:1413575084
    9,10-Anthracenedione; 9,10-Anthracenedione CFN92557 19852-76-7 C16H12O5 = 284.3 5mg QQ客服:1413575084
    吡啉; Purpurin CFN92566 81-54-9 C14H8O5 = 256.2 20mg QQ客服:1457312923
    1,8-二羟基蒽醌; Dantron CFN99271 117-10-2 C14H8O4 = 240.2 20mg QQ客服:1413575084

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