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  • 乙酰苍术素醇

    Acetylatractylodinol

    乙酰苍术素醇
    产品编号 CFN89539
    CAS编号 61582-39-6
    分子式 = 分子量 C15H12O3 = 240.25
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The roots of Atractylodes chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乙酰苍术素醇 CFN89539 61582-39-6 1mg QQ客服:1413575084
    乙酰苍术素醇 CFN89539 61582-39-6 5mg QQ客服:1413575084
    乙酰苍术素醇 CFN89539 61582-39-6 10mg QQ客服:1413575084
    乙酰苍术素醇 CFN89539 61582-39-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Católica Portuguesa (Portugal)
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  • Kyung Hee University (Korea)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2020, 25(9):2111.
  • bioRxiv - Molecular Biology2023, 535548.
  • J Ethnopharmacol.2020, 249:112381
  • Talanta.2022, 249:123645.
  • PLoS One.2022, 17(4):e0267007.
  • J Sep Sci.2018, 41(7):1682-1690
  • Molecules.2020, 25(21):5091.
  • Int J Mol Sci.2020, 21(22):8816.
  • QASCF2022, 14(4).
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Medicinal Chemistry Research 2021, 30:1117-1124.
  • Molecules.2017, 22(6)
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Phytomedicine.2019, 61:152813
  • Food Science and Biotechnology2015, 2205-2212
  • Antioxidants.2022, 11(3):592.
  • Processes2021, 9(1), 153.
  • Int J Mol Sci.2022, 23(10):5468.
  • Vet World.2023, 16(3):618-630.
  • Biochemistry.2018, 57(40):5886-5896
  • Int J Mol Sci.2015, 16(8):18396-411
  • South African J of Botany2020, 135:50-57
  • Biosci Rep.2018, 38(4)
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    Planta Med. 2001 Jul;67(5):437-42.
    Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity.[Pubmed: 11488458 ]

    METHODS AND RESULTS:
    From the rhizomes of Atractylodes lancea, 2-[(2'E)-3',7'-dimethyl-2',6'-octadienyl]-4-methoxy-6-methylphenol (1) was isolated as a new natural product. The compound showed strong inhibitory effects on 5-lipoxygenase (5-LOX) and cyclooxygenase-1 (COX-1), but exhibited only weak antioxidative activities [IC50 = 0.1 microM (5-LOX), 2 microM (COX-1), 9 microM (PMN/FMLP), 28 microM (PMNIOZ)]. Moreover, five new acetylenes were isolated and elucidated as (3Z,5E,11E)-tridecatriene-7,9-diynyl-1-O-(E)-ferulate (2), erythro-(1,3Z,11E)-tridecatriene-7,9-diyne-5,6-diyl diacetate (3), (1Z)-atractylodin (4), (1Z)-atractylodinol (5), (1Z)-Acetylatractylodinol (6) plus the known (4E,6E,12E)-tetradecatriene-8,10-diyne-1,3-diyl diacetate (7).
    CONCLUSIONS:
    Among the acetylenes, only 2 showed strong inhibition of 5-LOX and COX-1 activity (IC50 (5-LOX) = 3 microM, IC50 (COX-1) = 1 microM). In addition, the fatty acids linoleic acid, oleic acid and palmitic acid with previously established 5-LOX-/COX-1 inhibitory actions were identified as major constituents of the n-hexane extract and thus seem to contribute to the plant's in vitro activity.
    Pharmaceutical and pharmacological letters,1998,8(2):69-71.
    Antioxidant activity of constituents from Atractylodes lancea.[Reference: WebLink]
    Four polyacetylenes atractylodin, Acetylatractylodinol, 1-(2-furyl)-(7E)-nonene-3,5-diyne-1,2-diacetate, erythro-(1,5E, 11E)-tridecatriene-7,9-diyne-3,4-diacetate,as well as atractylochromene (I) and 2-[(2E)-3,7-dimethyl-2,6-octadienyl]-6-methyl-2,5-cyclohexadiene-1,4-dione (II) isolated from the rhizomes of Atractylodes lancea were evaluated for their antioxidant activity ex vivo.
    METHODS AND RESULTS:
    When measuring the inhibition of luminal enhanced chemiluminescence in stimulated human neutrophils, only the chromene I and the quinone II showed strong antioxidant activity. After stimulation with FMLP or opsonized zymosan (OZ) both compds. exhibited comparable inhibitory effects (IC50 I = 1.3 micro M (FMLP), 5.6 micro M (OZ); IC50 II = 1.1 micro M (FMLP), 5.4 micro M (OZ)). In contrast, I was considerably more active in a cell free in vitro assay with H2O2 and horseradish peroxidase (IC50 = 4.9 micro M I, 11 micro M II).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1623 mL 20.8117 mL 41.6233 mL 83.2466 mL 104.0583 mL
    5 mM 0.8325 mL 4.1623 mL 8.3247 mL 16.6493 mL 20.8117 mL
    10 mM 0.4162 mL 2.0812 mL 4.1623 mL 8.3247 mL 10.4058 mL
    50 mM 0.0832 mL 0.4162 mL 0.8325 mL 1.6649 mL 2.0812 mL
    100 mM 0.0416 mL 0.2081 mL 0.4162 mL 0.8325 mL 1.0406 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2-正戊基呋喃; 2-Pentylfuran CFN93061 3777-69-3 C9H14O = 138.2 20mg QQ客服:1457312923
    紫苏烯; Perillen CFN90862 539-52-6 C10H14O = 150.2 20mg QQ客服:2159513211
    (1,5E,11E)-tridecatriene-7,9-diyne-3,4-diacetate; (1,5E,11E)-tridecatriene-7,9-diyne-3,4-diacetate CFN95161 201012-14-8 C17H16O5 = 300.3 10mg QQ客服:2056216494
    苍术素; Atractylodin CFN99535 55290-63-6 C13H10O = 182.22 20mg QQ客服:1457312923
    乙酰苍术素醇; Acetylatractylodinol CFN89539 61582-39-6 C15H12O3 = 240.25 5mg QQ客服:2056216494
    糠酸; 2-糠酸; 2-呋喃甲酸; Furan-2-carboxylic acid CFN97598 88-14-2 C5H4O3 = 112.08 20mg QQ客服:1457312923
    3-糠酸;呋喃-3-甲酸; Furan-3-carboxylic acid CFN96899 488-93-7 C5H4O3 = 112.08 20mg QQ客服:215959384
    5-甲基-2-糠醛; 5-Methyl-2-furaldehyde CFN93066 620-02-0 C6H6O2 = 110.1 20mg QQ客服:2056216494
    5-羟甲基糠醛; 5-Hydroxymethylfurfural CFN97149 67-47-0 C6H6O3 = 126.1 20mg QQ客服:2056216494
    5-羟甲基-2-呋喃甲酸; 5-Hydroxymethyl-2-furoic acid CFN91519 6338-41-6 C6H6O4 = 142.1 20mg QQ客服:3257982914

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