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  • 9-羟基铁屎米酮

    9-Hydroxycanthin-6-one

    9-羟基铁屎米酮
    产品编号 CFN92126
    CAS编号 138544-91-9
    分子式 = 分子量 C14H8N2O2 = 236.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The barks of Ailanthus altissima
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    9-羟基铁屎米酮 CFN92126 138544-91-9 1mg QQ客服:215959384
    9-羟基铁屎米酮 CFN92126 138544-91-9 5mg QQ客服:215959384
    9-羟基铁屎米酮 CFN92126 138544-91-9 10mg QQ客服:215959384
    9-羟基铁屎米酮 CFN92126 138544-91-9 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Univerzita Karlova v Praze (Czech Republic)
  • University of Queensland (Australia)
  • University of Hertfordshire (United Kingdom)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Universitas islam negeri Jakarta (Indonesia)
  • Biotech R&D Institute (USA)
  • Helmholtz Zentrum München (Germany)
  • Aarhus University (Denmark)
  • Universidade Federal de Santa Catarina (Brazil)
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  • Lodz University of Technology (Poland)
  • University of Amsterdam (Netherlands)
  • University of Otago (New Zealand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Postharvest Biol Tec2019, 149:18-26
  • Front Plant Sci.2017, 8:723
  • Biomedicine & Pharmacotherapy2022, 153:113404.
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Molecules.2019, 24(12):E2286
  • PLoS One.2021, 16(9):e0257243.
  • Advances in Traditional Medicine 2021, 21:779-789.
  • Molecules2022, 27(14),4462
  • Evid Based Complement Alternat Med.2020, 2020:1970349.
  • Cell Rep.2020, 32(11):108158.
  • J Adv Res.2021, 35:245-257.
  • Biomed Chromatogr.2016, 30(10):1573-81
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • GENENCELL2023, 25:4356740
  • J Cell Biochem.2022, 123(7):1222-1236.
  • Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
  • Phytother Res.2019, 33(3):676-689
  • Int Immunopharmacol.2021, 100:108073.
  • Molecules.2022, 27(21):7514.
  • Food Analytical Methods2020, 13,1603-1612(2020)
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Toxicol Res.2019, 35(4):371-387
  • ...
  • 生物活性
    Description: 9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV probably through interfering with Ca2+ mobilization.9-Hydroxycanthin-6-one inhibits Wnt signaling through the activation of GSK3β independent of CK1α.
    Targets: Calcium Channel | Potassium Channel | GSK-3 | Wnt/β-catenin
    In vitro:
    J Sex Med. 2012 Apr;9(4):1027-36.
    9-hydroxycanthin-6-one induces penile erection and delays ejaculation.[Pubmed: 21569213]
    Eurycoma longifolia Jack (Simaroubaceae) has the reputation as a male aphrodisiac because it is claimed to increase virility and sexual prowess. Nevertheless, whether or not E. longifolia regulates directly the muscle tone of corpus cavernosa and/or seminal vesicle (SV) remains unclear. Even until now, the compositions that could account for its aphrodisiac property are still unknown.We examined the effect of 9-Hydroxycanthin-6-one (9-HC-6-one), a β-carboline alkaloid isolated from E. longifolia, on penile erection and ejaculation, and further elucidated the mechanism of action. 9-Hydroxycanthin-6-one induces penile erection and delays ejaculation.
    METHODS AND RESULTS:
    Drug's effect was studied on rat corpus cavernosum (CC) and SV in vitro, and on the changes in intracavernosal pressure (ICP) after IC injection and intraluminal pressure (ILP) of the SV after hypogastric nerve stimulation (HNS), respectively. 9-Hydroxycanthin-6-one relaxed significantly phenylephrine (PE)-precontracted CC. Such response was not attenuated by endothelium disruption, N(G) -nitro-L-arginine methyl ester, or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one treatment, suggesting that a nitric oxide/cyclic guanosine monophosphate-dependent pathway was precluded. 9-Hydroxycanthin-6-one attenuated PE-induced contraction by blocking cell surface and internal calcium channels with a higher potency for internal calcium release. This compound also antagonized calcium-evoked contraction in Ca2+ -free, high K+ -depolarizing condition, suggesting that interfering with the entry of calcium through voltage-dependent channels also contributed to 9-Hydroxycanthin-6-one-induced corporal relaxation. After IC application of 9-Hydroxycanthin-6-one, a significant rise in ICP was observed as compared with the application of normal saline. 9-Hydroxycanthin-6-one relaxed significantly norepinephrine (NE)- and KCl-precontracted SV, and antagonized NE-induced oscillatory contraction as potent as clomipramine. Finally, the HNS-evoked increase in ILP was dose-dependently repressed after challenge by 9-Hydroxycanthin-6-one.
    CONCLUSIONS:
    9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV probably through interfering with Ca2+ mobilization.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2337 mL 21.1685 mL 42.337 mL 84.674 mL 105.8425 mL
    5 mM 0.8467 mL 4.2337 mL 8.4674 mL 16.9348 mL 21.1685 mL
    10 mM 0.4234 mL 2.1169 mL 4.2337 mL 8.4674 mL 10.5843 mL
    50 mM 0.0847 mL 0.4234 mL 0.8467 mL 1.6935 mL 2.1169 mL
    100 mM 0.0423 mL 0.2117 mL 0.4234 mL 0.8467 mL 1.0584 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    铁屎米酮; Canthin-6-one CFN98730 479-43-6 C14H8N2O = 220.2 5mg QQ客服:1413575084
    铁屎米酮 N氧化物; Canthin-6-one N-oxide CFN92010 60755-87-5 C14H8N2O2 = 236.2 5mg QQ客服:2056216494
    1-羟基-6-铁屎米酮; 1-Hydroxycanthin-6-one CFN97287 80787-59-3 C14H8N2O2 = 236.2 5mg QQ客服:3257982914
    9-羟基铁屎米酮; 9-Hydroxycanthin-6-one CFN92126 138544-91-9 C14H8N2O2 = 236.2 5mg QQ客服:2159513211
    10-羟基-6-铁屎米酮; 10-Hydroxycanthin-6-one CFN94012 86293-41-6 C14H8N2O2 = 236.23 5mg QQ客服:2056216494
    9-甲氧基铁屎米酮; 9-Methoxycanthin-6-one CFN92011 74991-91-6 C15H10N2O2 = 250.3 5mg QQ客服:1457312923
    9-甲氧基铁屎米酮 N氧化物; 9-Methoxycanthin-6-one-N-oxide CFN92012 137739-74-3 C15H10N2O3 = 266.3 5mg QQ客服:2056216494
    1-羟基-9-甲氧基铁屎米酮; 1-Hydroxy-9-medroxycanthin-6-one CFN92124 622408-85-9 C15H10N2O3 = 266.3 5mg QQ客服:2056216494
    11-羟基-6-铁屎米酮; 11-Hydroxycanthin-6-one CFN92125 75969-83-4 C14H8N2O2 = 236.2 5mg QQ客服:1457312923
    9,10-二甲氧基铁屎米酮; 9,10-Dimethoxycanthin-6-one CFN92127 155861-51-1 C16H12N2O3 = 280.3 5mg QQ客服:2159513211

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