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  • 9-酮-泽兰素

    • 9-酮-泽兰素

    9-Oxoageraphorone

    9-酮-泽兰素
    		产品编号 CFN99071
    CAS编号 105181-06-4
    分子式 = 分子量 C15H22O2 = 234.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Eupatorium adenophorum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    9-酮-泽兰素 CFN99071 105181-06-4 1mg QQ客服：2056216494
    9-酮-泽兰素 CFN99071 105181-06-4 5mg QQ客服：2056216494
    9-酮-泽兰素 CFN99071 105181-06-4 10mg QQ客服：2056216494
    9-酮-泽兰素 CFN99071 105181-06-4 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Complutense University of Madrid (Spain)
  • University of Toulouse (France)
  • University of Melbourne (Australia)
  • Subang Jaya Medical Centre (Malaysia)
  • Auburn University (USA)
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  • University of Hull (United Kingdom)
  • Medical University of South Carolina (USA)
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  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Malaya (Malaysia)
  • University of Wollongong (Australia)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plants (Basel).2021, 10(5):951.
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • International J of Green Pharmacy2019, 13(3)
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Mediators Inflamm.2016, 2016:7216912
  • Molecules.2023, 28(9):3685.
  • BMC Complement Altern Med.2014, 14:242
  • Biofactors.2018, 44(2):168-179
  • Korean J. Food Sci. & Technol.2022, 54(2):241-246
  • Pharmacol Res.2020, 161:105205.
  • Front Microbiol.2020, 11:583594.
  • Int Immunopharmacol.2023, 123:110572.
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Korean Herb. Med. Inf.2021, 9(2):231-239.
  • Molecules2022, 27(12):3903.
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • Phytomedicine.2016, 23(4):331-9
  • Advances in Traditional Medicine2020, 10.1007
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Elife.2021, 10:e68058.
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • Int J Mol Sci.2021, 22(16):8641.
  • ...
    • 生物活性
    Description: 9-Oxoageraphorone has strong acaricidal activity against P. cuniculi in vitro, it also exhibits high insecticidal effects.
    In vitro:
    Vet.Parasitol.,2014 Jun 16;203(1-2):197-202.
    Isolation and identification of acaricidal compounds in Eupatorium adenophorum petroleum ether extract and determination of their acaricidal activity against Psoroptes cuniculi.[Pubmed: 24569033 ]

    METHODS AND RESULTS:
    We used multiple silica gel column chromatography and thin-layer chromatography coupled with (1)H nuclear magnetic resonance (NMR) and (13)C NMR to separate and identify the active acaricidal ingredients in Eupatorium adenophorum petroleum ether extract. The acaricidal activity of each compound was tested against Psoroptes cuniculi in vitro. Three compounds had strong acaricidal activity against P. cuniculi in vitro. The insecticidal effect of 0.5% compound 9β-hydroxy-ageraphorone was better than the insecticidal effect of fenvalerate, and compounds 9-Oxoageraphorone and 9-oxo-10,11-dehydro-ageraphorone exhibited higher insecticidal effects than 9β-hydroxy-ageraphorone.
    CONCLUSIONS:
    Thus, the E. adenophorum petroleum ether extract contains an effective composition of acaricides that could potentially be developed as a promising plant-origin acaricide.
    In vivo:
    Nat Prod Bioprospect. 2014 Dec 12.
    Toxicity Assessment of Cadinene Sesquiterpenes from Eupatorium adenophorum in Mice.[Pubmed: 25500813]

    METHODS AND RESULTS:
    We firstly tested median lethal dose (LD50) in mice of three cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9-Oxoageraphorone (DAOA), 9-oxoagerophorone (OA) and 9-oxo-10,11-dehydro-agerophorone (ODA) from Eupatorium adenophorum (Ea). DAOA (215-4640 mg/kg BW, given orally) showed lowest LD50 at 926 mg/kg BW for male mice in contrast with 9-oxoagerophorone (1470 mg/kg BW) and ODA (1470 mg/kg BW).
    CONCLUSIONS:
    In sub-acute study, repeated doses (75-300 mg/kg BW, for 7 days) of DAOA/9-oxoagerophorone increased blood parameters, liver and spleen index in dose dependent relationship, along with decrease in thymus index. 75 mg/kg dose of DAOA/9-oxoagerophorone was found to be approximately/totally safe over the span of 7 days treatment showing no change in all above described parameters.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Ylangenol; Ylangenol CFN96415 41610-69-9 C15H24O = 220.35 5mg QQ客服：215959384
    10(14)-杜松萜烯-4,5-二醇; 10(14)-Cadinene-4,5-diol CFN97146 672336-50-4 C15H26O2 = 238.4 5mg QQ客服：1457312923
    异水菖蒲二醇; Isocalamendiol CFN98278 25330-21-6 C15H26O2 = 238.4 5mg QQ客服：1413575084
    10-O-乙酰异水菖蒲二醇; 10-O-Acetylisocalamendiol CFN96767 1432064-69-1 C17H28O3 = 280.40 5mg QQ客服：1457312923
    4-杜松萜烯-7-醇; 4-Cadinen-7-ol CFN98081 217650-27-6 C15H26O = 222.4 5mg QQ客服：1413575084
    (-)-Cadin-4,10(15)-dien-11-oic acid; (-)-Cadin-4,10(15)-dien-11-oic acid CFN95246 1124353-23-6 C15H22O2 = 234.3 5mg QQ客服：2056216494
    3-乙酰氧基-4-杜松萜烯-8-酮; 3-Acetoxy-4-cadinen-8-one CFN97485 923950-05-4 C17H26O3 = 278.4 5mg QQ客服：3257982914
    9-酮-泽兰素; 9-Oxoageraphorone CFN99071 105181-06-4 C15H22O2 = 234.3 5mg QQ客服：2056216494
    去氢白菖烯-3,7-二醇; 1,3,5-Cadinatriene-3,8-diol CFN97514 941227-27-6 C15H22O2 = 234.3 5mg QQ客服：1413575084
    8-羟基-4-荜澄茄烯-3-酮; 8-Hydroxy-4-cadinen-3-one CFN97550 97372-53-7 C15H24O2 = 236.4 5mg QQ客服：2159513211

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