Info: Read More
  • 中药标准品生产商,产品定制服务
  • 9-氨基喜树碱

    9-Aminocamptothecin

    9-氨基喜树碱
    产品编号 CFN90309
    CAS编号 91421-43-1
    分子式 = 分子量 C20H17N3O4 = 363.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The barks of Camptotheca acuminata Decne
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    9-氨基喜树碱 CFN90309 91421-43-1 10mg QQ客服:1457312923
    9-氨基喜树碱 CFN90309 91421-43-1 20mg QQ客服:1457312923
    9-氨基喜树碱 CFN90309 91421-43-1 50mg QQ客服:1457312923
    9-氨基喜树碱 CFN90309 91421-43-1 100mg QQ客服:1457312923
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Charles University in Prague (Czech Republic)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • MTT Agrifood Research Finland (Finland)
  • Lund University (Sweden)
  • Kyoto University (Japan)
  • John Innes Centre (United Kingdom)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Florida A&M University (USA)
  • Celltrion Chemical Research Institute (Korea)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Melbourne University (Australia)
  • Universitas islam negeri Jakarta (Indonesia)
  • Universite Libre de Bruxelles (Belgium)
  • University of Stirling (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2023, 28(8):3414.
  • Food Analytical Methods2020, 13,1603-1612(2020)
  • Histol Histopathol.2022, 18518.
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • Industrial Crops and Products2022, 188:115638
  • Biomolecules.2022, 12(12):1754.
  • Antioxidants (Basel).2022, 11(12):2496.
  • Molecules.2022, 27(19):6651.
  • Front Cell Dev Biol.2021, 9:588093.
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • J Sep Sci.2018, 41(7):1682-1690
  • Antioxidants (Basel).2021, 10(3):379.
  • JABS2020, 14:2(2020)
  • Front Pharmacol.2021, 12:652860.
  • Plants2022, 11(3),294.
  • Pharmacol Rep.2020, 72(2):472-480.
  • Evid-Based Compl Alt2020, 7202519:13
  • Food Chem.2021, 377:131976.
  • Arch Pharm Res.2015, 38(6):1080-9
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • Arch Biochem Biophys.2020, 687:108384.
  • J.Pharm. & Biome. Anal.2023, 2: 100018.
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • ...
  • 生物活性
    Description: 9-Aminocamptothecin is a topoisomerase I inhibitor with potent anticancer activity.In combination with 9-Aminocamptothecin, one 15-mer peptide (SAYAATVRGPLSSAS) has synergistic cytotoxic effects with 9-Aminocamptothecin both in the cytotoxicity assay and in nude mouse xenograft human tumor models.
    Targets: P450 (e.g. CYP17)
    In vitro:
    Int J Oncol. 2014 Aug;45(2):877-86.
    Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy.[Pubmed: 24889073]
    The metabolism of 9-Aminocamptothecin (9-AC) was investigated in human and rat liver microsomes.
    METHODS AND RESULTS:
    In both species 9-Aminocamptothecin was almost exclusively biotransformed to dihydroxy-9-Aminocamptothecin (M1) and monohydroxy-9-Aminocamptothecin (M2). The enzymatic efficiencies of the formation of M1 and M2 (V(max)/K(m)) were 1.7- and 2.7‑fold higher in rat than in human liver microsomes indicating species-related differences in 9-Aminocamptothecin hydroxylation. Incubation in the presence of human recombinant cytochrome P450 (CYP) enzymes demonstrated that the formation of M1 and M2 is mainly catalyzed by CYP3A4 and only to a minor extent by extrahepatic CYP1A1. The predominant role of CYP3A4 was further supported by a dramatic inhibition of metabolite formation in the presence of the CYP3A4 substrates troleandomycin and ketoconazole. Experiments conducted in isolated perfused rat livers further demonstrated that biliary excretion of 9-Aminocamptothecin, M1 and M2 during 60 min of perfusion was pronounced and accounted for 17.7±2.59, 0.05±0.01 and 2.75±0.14% of total 9-Aminocamptothecin applied to the liver, respectively.
    CONCLUSIONS:
    In summary, this study established that CYP3A-dependent hydroxylation is the main metabolic pathway for 9-Aminocamptothecin in rat and human liver, which have to be taken into consideration during cancer therapy of patients.
    In vivo:
    Macromol Biosci. 2009 Nov 10;9(11):1135-42.
    Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.[Pubmed: 19685500 ]
    The antitumor activity of a colon-specific N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer - 9-aminocamptothecin (9-AC) conjugate (P-9-AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models.
    METHODS AND RESULTS:
    P-9-AC treatment of mice bearing orthotopic colon tumors, with a dose of 3 mg/kg of 9-AC equivalent every other day for 6 weeks, resulted in regression of tumors in 9 of 10 mice. A lower dose of P-9-AC (1.25 mg/kg of 9-AC equivalent) every other day for 8 weeks inhibited subcutaneous tumor growth in all mice. No liver metastases were observed.
    CONCLUSIONS:
    Colon-specific release of 9-AC from polymer conjugates enhanced antitumor activity and minimized the systemic toxicity.
    Cancer Chemother Pharmacol. 2009 Apr;63(5):793-8.
    Phase II study of 9-aminocamptothecin in previously treated lymphomas: results of Cancer and Leukemia Group B 9551.[Pubmed: 18648813]
    To evaluate the efficacy and toxicity of the topoisomerase I inhibitor, 9-aminocamptothecin (9-AC), in patients with relapsed lymphoma and to correlate 9-AC plasma concentrations with response and toxicity.
    METHODS AND RESULTS:
    Eligible patients had relapsed Hodgkin lymphoma (HL) treated with one or two prior regimens, low grade non-Hodgkin's lymphoma (NHL) treated with one or two prior regimens, or aggressive NHL treated with one prior regimen. The first nine patients received 9-AC dimethylacetamide 0.85 mg/m(2) per day intravenously over 72 h every 2 weeks and the remaining 27 patients received 9-AC/colloidal dispersion 1.1 mg/m(2) per day. Patients received a minimum of three cycles unless progression or intolerable toxicity occurred. Responding patients received two cycles past best response with a minimum of six cycles. CALGB 9551 accrued 37 patients from April 1996 through October 2000; one patient with HD, 18 patients with indolent lymphoma, and 17 patients with aggressive lymphoma. The overall response rate was 17%, with response rates of 11% (2 partial responses) in patients with indolent histologies and 23% (1 complete response, 3 partial responses) in patients with aggressive histologies. The patient with HD did not respond. Response rates were similar for both drug formulations. The median remission duration for the six responders was 6.5 months, with one remission lasting longer than 12 months. Significant grade 3 and 4 toxicities included neutropenia (66%), anemia (31%), and thrombocytopenia (36%), with 20% of patients experiencing grade 3 or 4 infection. No treatment related deaths occurred. Steady state serum concentrations did not correlate with patient response or toxicity.
    CONCLUSIONS:
    Single agent 9-AC has modest activity in aggressive non-Hodgkin's lymphomas.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.752 mL 13.7601 mL 27.5202 mL 55.0403 mL 68.8004 mL
    5 mM 0.5504 mL 2.752 mL 5.504 mL 11.0081 mL 13.7601 mL
    10 mM 0.2752 mL 1.376 mL 2.752 mL 5.504 mL 6.88 mL
    50 mM 0.055 mL 0.2752 mL 0.5504 mL 1.1008 mL 1.376 mL
    100 mM 0.0275 mL 0.1376 mL 0.2752 mL 0.5504 mL 0.688 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    9-甲氧基喜树碱; 9-Methoxycamptothecine CFN99729 39026-92-1 C21H18N2O5 = 378.38 20mg QQ客服:2056216494
    9-氨基喜树碱; 9-Aminocamptothecin CFN90309 91421-43-1 C20H17N3O4 = 363.37 20mg QQ客服:1413575084
    (S)-10-羟基喜树碱; (S)-10-Hydroxycamptothecin CFN99735 19685-09-7 C20H16N2O5 = 364.35 20mg QQ客服:2159513211
    10-甲氧基喜树碱; 10-Methoxycamptothecin CFN90157 19685-10-0 C21H18N2O5 = 378.38 5mg QQ客服:2056216494
    鲁比替康; Rubitecan CFN93013 91421-42-0 C20H15N3O6 = 393.35 5mg QQ客服:1413575084
    10-硝基喜树碱; 10-Nitro-camptothecin CFN90439 104195-61-1 C20H15N3O6 = 393.34 5mg QQ客服:1457312923
    盐酸拓扑替康; Topotecan hydrochloride CFN90462 119413-54-6 C23H24ClN3O5 = 457.9 20mg QQ客服:1457312923
    盐酸依立替康; Irinotecan hydrochloride CFN90886 100286-90-6 C33H39ClN4O6 = 623.2 20mg QQ客服:1457312923
    7-乙基喜树碱; 7-Ethylcamptothecin CFN90336 78287-27-1 C22H20N2O4 = 376.41 20mg QQ客服:1457312923
    7-乙基-10-羟基喜树碱; 7-Ethyl-10-Hydroxycamptothecin CFN90335 86639-52-3 C22H20N2O5 = 392.4 20mg QQ客服:2056216494

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产