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  • 9,9'-二-O-(E)-阿魏酰开环异落叶松脂素

    9,9'-Di-O-(E)-feruloylsecoisolariciresinol

    9,9'-二-O-(E)-阿魏酰开环异落叶松脂素
    产品编号 CFN98956
    CAS编号 56973-66-1
    分子式 = 分子量 C40H42O12 = 714.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herb of Betula ermanii.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    9,9'-二-O-(E)-阿魏酰开环异落叶松脂素 CFN98956 56973-66-1 1mg QQ客服:3257982914
    9,9'-二-O-(E)-阿魏酰开环异落叶松脂素 CFN98956 56973-66-1 5mg QQ客服:3257982914
    9,9'-二-O-(E)-阿魏酰开环异落叶松脂素 CFN98956 56973-66-1 10mg QQ客服:3257982914
    9,9'-二-O-(E)-阿魏酰开环异落叶松脂素 CFN98956 56973-66-1 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Cornell University (USA)
  • Monash University Malaysia (Malaysia)
  • Periyar University (India)
  • Istanbul University (Turkey)
  • University of Amsterdam (Netherlands)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Indian Institute of Science (India)
  • Universidade de Franca (Brazil)
  • Universite de Lille1 (France)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Melbourne (Australia)
  • Universit?t Basel (Switzerland)
  • Tohoku University (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2021, 11(1):11936.
  • Food Chem.2019, 278:683-691
  • Food and Fermentation Industries2018, 44(371)
  • Front Aging Neurosci.2019, 11:230
  • Molecules.2023, 28(7):3039.
  • Sci Rep.2021, 11(1):10931.
  • Nat Commun.2021, 12(1):681.
  • Molecules.2021, 26(2):E255.
  • Anticancer Res.2020, 40(10):5529-5538.
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Int J Mol Sci.2020, 21(8):2790.
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Sci Rep. 2018, 1-9
  • Int Immunopharmacol.2019, 71:361-371
  • Industrial Crops and Products2020, 146:112186
  • Antioxidants.2022, 11(3):491.
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • Bio-protocol2018, 9(14):e3301
  • Journal of Phytopathology2021, 169,Issue11-12.
  • Food Research International2016, 106-113
  • ...
  • 生物活性
    Description: 1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer activity. (+)-9,9′-O-Diferuloylsecoisolariciresinol has significant cytotoxic activity against the DU145, LNCaP, and A549 cell lines.
    Targets: mTOR
    In vitro:
    Chemistry of Natural Compounds, 2014, 50(6): 978-81.
    Phytochemical Investigation and Cytotoxic Evaluation of Components of Leaves and Stems of Machilus zuihoensis var. mushaensis[Reference: WebLink]

    METHODS AND RESULTS:
    From the MeOH extract of the leaves and stems of Machilus zuihoensis var. mushaensis, one new lignan, machilolin-B (1), together with 10 known compounds, zuonin B (2), (+)-9,9′-O-diferuloylsecoisolariciresinol (9,9'-Di-O-(E)-feruloylsecoisolariciresinol,3), (E)-3-(3-hydroxybut-1-enyl)-2,4,4-trimethylcyclohexa-2,5-dienone (4), 5-[(1R,5R,8S)-8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo[3.2.1]oct-8-yl]-3-methyl-2,4-pentadienoic acid (5), vanillin (6), rhamnetin-3-O-β-D-galactopyranoside (7), 2-hydroxy-3,4-dioxopentanal (8), a mixture of β-sitosterol (9) and stigmasterol (10), and β-sitosteryl-β-D-glucoside (11), have been isolated.
    CONCLUSIONS:
    Among them, compound 3 was demonstrated to have significant cytotoxic activity against the DU145, LNCaP, and A549 cell lines. Compound 11 also possessed moderate antiproliferative activities against DU145 cell lines.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.399 mL 6.995 mL 13.9899 mL 27.9799 mL 34.9748 mL
    5 mM 0.2798 mL 1.399 mL 2.798 mL 5.596 mL 6.995 mL
    10 mM 0.1399 mL 0.6995 mL 1.399 mL 2.798 mL 3.4975 mL
    50 mM 0.028 mL 0.1399 mL 0.2798 mL 0.5596 mL 0.6995 mL
    100 mM 0.014 mL 0.0699 mL 0.1399 mL 0.2798 mL 0.3497 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    安五脂素; Anwulignan CFN98539 107534-93-0 C20H24O4 = 328.41 20mg QQ客服:2056216494
    赤式-6-澳白木脂素; erythro-Austrobailignan-6 CFN95501 114127-24-1 C20H24O4 = 328.4 10mg QQ客服:215959384
    Schineolignin B; Schineolignin B CFN92717 1352185-26-2 C22H30O5 = 374.5 5mg QQ客服:2056216494
    华中五脂素; Sphenanlignan CFN95245 866347-36-6 C21H26O5 = 358.4 5mg QQ客服:3257982914
    Arisanschinin E; Arisanschinin E CFN95221 1333378-33-8 C21H28O5 = 360.5 5mg QQ客服:1413575084
    前五味子脂素; Pregomisin CFN96694 66280-26-0 C22H30O6 = 390.47 10mg QQ客服:1457312923
    脱水开环异落叶松树脂酚; Anhydrosecoisolariciresinol CFN89236 29388-33-8 C20H24O5 = 344.40 5mg QQ客服:3257982914
    4,4'-[[(2S,3S,4S)-四氢-2-甲氧基-3,4-呋喃二基]二(亚甲基)]二[2-甲氧基苯酚]; 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan CFN96711 1206464-65-4 C21H26O6 = 374.43 5mg QQ客服:1457312923
    开环异落叶松树脂酚; Secoisolariciresinol CFN98363 29388-59-8 C20H26O6 = 362.4 10mg QQ客服:2056216494
    开环异落叶松树脂素一苷; Secoisolariciresinol monoglucoside CFN96682 63320-67-2 C26H36O11 = 524.56 5mg QQ客服:3257982914

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