8-姜烯酚

8-Shogaol

	产品编号	CFN92299
	CAS编号	36700-45-5
	分子式 = 分子量	C₁₉H₂₈O₃ = 304.4
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Phenols
	植物来源	The rhizomes of Zingber officinale Rosc.
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产品名称	产品编号	CAS编号	包装	QQ客服
8-姜烯酚	CFN92299	36700-45-5	10mg	QQ客服：2159513211
8-姜烯酚	CFN92299	36700-45-5	20mg	QQ客服：2159513211
8-姜烯酚	CFN92299	36700-45-5	50mg	QQ客服：2159513211
8-姜烯酚	CFN92299	36700-45-5	100mg	QQ客服：2159513211

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Description:

8-Shogaol can induce apoptosis in a time- and concentration-dependent manner by reactive oxygen species production and depletion of glutathione in HL-60 cells.

Targets:

ROS

In vitro:

Drug Metab Dispos . 2015 Aug;43(8):1181-9.

Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis[Pubmed: 25986850]

Abstract Pregnane X receptor (PXR) activation exhibits anti-inflammatory effects via repressing nuclear factor-κB (NF-κB); however, its overactivation may disrupt homeostasis of various enzymes and transporters. Here we found that ginsenosides restore PXR/NF-κB signaling in inflamed conditions without disrupting PXR function in normal conditions. The effects and mechanisms of ginsenosides in regulating PXR/NF-κB signals were determined both in vitro and in vivo. Ginsenosides significantly inhibited NF-κB activation and restored the expression of PXR target genes in tumor necrosis factor-α-stimulated LS174T cells. Despite not being PXR agonists, ginsenosides repressed NF-κB activation in a PXR-dependent manner. Ginsenosides significantly increased the physical association between PXR and the NF-κB p65 subunit and thereby decreased the nuclear translocation of p65. Ginsenoside Rb1 and compound K (CK) were major bioactive compounds in the regulating PXR/NF-κB signaling. Consistently, ginsenosides significantly attenuated dextran sulfate sodium-induced experimental colitis, which was associated with restored PXR/NF-κB signaling. This study indicates that ginsenosides may elicit anti-inflammatory effects via targeting PXR/NF-κB interaction without disrupting PXR function in healthy conditions. Ginsenoside Rb1 and CK may serve as leading compounds in the discovery of new drugs that target PXR/NF-κB interaction in therapy for inflammatory bowel disease.

In vivo:

Mol Nutr Food Res. 2013 Mar;57(3):447-58.

Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.[Pubmed: 23322393]

Shogaols, a series of major constituents in dried ginger with the most abundant being [6]-, [8]-, and [10]-shogaols, show much higher anticancer potencies than gingerols. Previously, we reported the mercapturic acid pathway as a major metabolic route for [6]-shogaol in mice. However, it is still unclear how the side chain length affects the metabolism of shogaols and how shogaols are metabolized in humans.
METHODS AND RESULTS:
We first investigate the metabolism of [10]-shogaol in mouse urine, and then investigate the biotransformation of shogaols in human urine. Our results show that eight major thiol-conjugated metabolites of [10]-shogaol were detected in mouse urine, while six major thiol-conjugated metabolites of [6]-shogaol, two thiol-conjugated metabolites of 8-Shogaol, and two thiol-conjugated metabolites of [10]-shogaol were detected in urine collected from human after drinking ginger tea, using LC/ESI-MS/MS. Our results clearly indicate the mercapturic acid pathway is a major metabolic route for [10]-shogaol in mice and for shogaols in human. Furthermore, we also investigated the regulation of glutathione (GSH) by [6]-shogaol in human colon cancer cells HCT-116. Our results show [6]-shogaol, after initially depleting glutathione levels, can subsequently restore and increase GSH levels over time.
CONCLUSIONS:
Shogaols are metabolized extensively in mouse and human to form thiol-conjugated metabolites and GSH might play an important role in the cancer-preventive activity of ginger.

Oxid Med Cell Longev . 2015;2015:843721.

Ginsenoside Rb1 Treatment Attenuates Pulmonary Inflammatory Cytokine Release and Tissue Injury following Intestinal Ischemia Reperfusion Injury in Mice[Pubmed: 26161243]

Abstract Objective. Intestinal ischemia reperfusion (II/R) injury plays a critical role in remote organ dysfunction, such as lung injury, which is associated with nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. In the present study, we tested whether ginsenoside Rb1 attenuated II/R induced lung injury by Nrf2/HO-1 pathway. Methods. II/R injury was induced in male C57BL/6J mice by 45 min of superior mesenteric artery (SMA) occlusion followed by 2 hours of reperfusion. Ginsenoside Rb1 was administrated prior to reperfusion with or without ATRA (all-transretinoic acid, the inhibitor of Nrf2/ARE signaling pathway) administration before II/R. Results. II/R induced lung histological injury, which is accompanied with increased levels of malondialdehyde (MDA), interleukin- (IL-) 6, and tumor necrosis factor- (TNF-) α but decreased levels of superoxide dismutase (SOD) and IL-10 in the lung tissues. Ginsenoside Rb1 reduced lung histological injury and the levels of TNF-α and MDA, as well as wet/dry weight ratio. Interestingly, the increased Nrf2 and HO-1 expression induced by II/R in the lung tissues was promoted by ginsenoside Rb1 treatment. All these changes could be inhibited or prevented by ATRA. Conclusion. Ginsenoside Rb1 is capable of ameliorating II/R induced lung injuries by activating Nrf2/HO-1 pathway.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
二乙酰氧基-4-姜二醇; Diacetoxy-4-gingerdiol	CFN92373	863780-88-5	C₁₉H₂₈O₆ = 352.4	5mg	QQ客服：2056216494
甲基二乙酰氧基-6-姜二醇; Methyl diacetoxy-6-gingerdiol	CFN92301	863780-90-9	C₂₂H₃₄O₆ = 394.5	5mg	QQ客服：2159513211
1-脱氢-6-姜酮; 1-Dehydro-6-gingerdione	CFN92298	76060-35-0	C₁₇H₂₂O₄ = 290.4	10mg	QQ客服：1413575084
6-姜烯酚; 6-Shogaol	CFN99531	555-66-8	C₁₇H₂₄O₃ = 276.37	20mg	QQ客服：2056216494
二乙酰氧基-6-姜二醇; Diacetoxy-6-gingerdiol	CFN92375	143615-75-2	C₂₁H₃₂O₆ = 380.5	5mg	QQ客服：2056216494
二氢非洲豆蔻醇; Dihydroparadol	CFN91532	143111-84-6	C₁₇H₂₈O₃ = 280.4	10mg	QQ客服：1413575084
非洲豆蔻醇; Paradol	CFN91045	27113-22-0	C₁₇H₂₆O₃ = 278.39	10mg	QQ客服：3257982914
(E)-[6]-去氢非洲豆蔻醇; (E)-[6]-Dehydroparadol	CFN91531	878006-06-5	C₁₇H₂₄O₃ = 276.4	5mg	QQ客服：2159513211
8-姜烯酚; 8-Shogaol	CFN92299	36700-45-5	C₁₉H₂₈O₃ = 304.4	20mg	QQ客服：2159513211
10-姜烯酚; 10-Shogaol	CFN92300	36752-54-2	C₂₁H₃₂O₃ = 332.5	20mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2852 mL	16.4258 mL	32.8515 mL	65.703 mL	82.1288 mL
5 mM	0.657 mL	3.2852 mL	6.5703 mL	13.1406 mL	16.4258 mL
10 mM	0.3285 mL	1.6426 mL	3.2852 mL	6.5703 mL	8.2129 mL
50 mM	0.0657 mL	0.3285 mL	0.657 mL	1.3141 mL	1.6426 mL
100 mM	0.0329 mL	0.1643 mL	0.3285 mL	0.657 mL	0.8213 mL

8-姜烯酚

8-Shogaol

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