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  • 7'(Z)-(8''R,8'''R)-表-丹酚酸E

    7'(Z)-(8''R,8'''R)-epi-salvianolic acid E

    7'(Z)-(8''R,8'''R)-表-丹酚酸E
    产品编号 CFN80290
    CAS编号 N/A
    分子式 = 分子量 C36H30O16 = 718.15
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Salvia miltiorrhiza Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7'(Z)-(8''R,8'''R)-表-丹酚酸E CFN80290 N/A 1mg QQ客服:2056216494
    7'(Z)-(8''R,8'''R)-表-丹酚酸E CFN80290 N/A 5mg QQ客服:2056216494
    7'(Z)-(8''R,8'''R)-表-丹酚酸E CFN80290 N/A 10mg QQ客服:2056216494
    7'(Z)-(8''R,8'''R)-表-丹酚酸E CFN80290 N/A 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Planta Med.2019, 85(9-10):766-773
  • Int Immunopharmacol.2020, 90:107268.
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Molecules.2019, 24(4):E709
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Aging (Albany NY).2021, 13(19):22867-22882.
  • Ann Transl Med.2019, 7(23):731
  • Front Pharmacol.2021, 12:762829.
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • Primary and Industrial.2018, 52(11)
  • Natural Product Communications2020, doi: 10.1177.
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • Sci Rep.2020, 10:4495(2020)
  • Journal of Analytical Chemistry2017, 854-861
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • Toxicol Rep.2021, 8:1131-1142.
  • Antioxidants (Basel).2020, 9(4):326.
  • Phytomedicine.2017, 24:77-86
  • Biochem Biophys Res Commun.2021, 534:802-807.
  • Front Pharmacol.2018, 9:756
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:6-12.
    Development and validation of a UFLC-MS/MS method for determination of 7'(Z)-(8″S, 8‴S)-epi-salvianolic acid E, (7'R, 8'R, 8″S, 8‴S)-epi-salvianolic acid B and salvianolic acid B in rat plasma and its application to pharmacokinetic studies.[Pubmed: 27064533]
    7'(Z)-(8″S, 8‴S)-epi-Salvianolic acid E (compound 1) and (7'R, 8'R, 8″S, 8‴S)-epi-salvianolic acid B (compound 2), two novel analogs of salvianolic acid B (Sal B), have been recently isolated from Salvianolic acid for injection. They both show powerful antioxidant effects, including inducing NQO1 activity and scavenging DPPH free radical, and potential protecting effects for cerebral ischemia. However, no reports have been described the pharmacokinetic study of them.
    METHODS AND RESULTS:
    In this study, an ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was developed and validated for the determination of compound 1, compound 2 and Sal B in rat plasma, respectively. Plasma samples were pretreated by liquid-liquid extraction with ethyl acetate. Chromatographic separation was achieved on a Waters Acquity UPLC(®) HSS T3 column (1.7μm particles, 2.1mm i.d.×100mm) with the mobile phase of 0.1% aqueous formic acid (A)-acetonitrile (B) (65:35, v/v). Quantification was performed on a triple quadruple tandem mass spectrometry with electrospray ionization (ESI) by multiple reaction monitoring (MRM) in the negative ion mode. Monitored transitions were set at m/z 717.0→519.0, 717.1→519.1, 717.2→518.9 and 320.9→152.1 for compound 1, compound 2, Sal B and chloramphenicol (internal standard, IS), respectively. Linear calibration curves were acquired over the concentration range of 2.0-1000ng/mL for the three analytes in rat plasma. The extraction recoveries, matrix effects, intra- and inter-day precisions and accuracies of the three analytes were all within acceptable limits. The validated method was successfully applied to the pharmacokinetic study of compound 1, compound 2 and Sal B after intravenous administration of 6.0mg/kg in rats, respectively.
    CONCLUSIONS:
    The results indicated that compound 1 and compound 2 were both eliminated more slowly than Sal B. Exposure levels of both compound 1 and Sal B were higher than compound 2 in the same dosage range. This study provided critical reference for the pharmacokinetic study of compound 1 and compound 2.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3925 mL 6.9623 mL 13.9247 mL 27.8493 mL 34.8117 mL
    5 mM 0.2785 mL 1.3925 mL 2.7849 mL 5.5699 mL 6.9623 mL
    10 mM 0.1392 mL 0.6962 mL 1.3925 mL 2.7849 mL 3.4812 mL
    50 mM 0.0278 mL 0.1392 mL 0.2785 mL 0.557 mL 0.6962 mL
    100 mM 0.0139 mL 0.0696 mL 0.1392 mL 0.2785 mL 0.3481 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    迷迭香酸; Rosmarinic acid CFN99103 20283-92-5 C18H16O8 = 360.31 20mg QQ客服:3257982914
    迷迭香酸甲酯; Methyl rosmarinate CFN97567 99353-00-1 C19H18O8 = 374.4 20mg QQ客服:2056216494
    迷迭香酸-4-氧-葡萄糖苷; Rosmarinyl glucoside CFN95297 910028-78-3 C24H26O13 = 522.5 5mg QQ客服:1457312923
    Clinopodic acid E; Clinopodic acid E CFN95595 159736-38-6 C27H22O12 = 538.5 5mg QQ客服:2056216494
    丹酚酸D; Salvianolic acid D CFN90223 142998-47-8 C20H18O10 = 492.44 5mg QQ客服:2159513211
    丹酚酸A; Salvianolic acid A CFN99161 96574-01-5 C26H22O10 = 494.45 20mg QQ客服:2056216494
    丹酚酸A甲酯; Methyl salvionolate A CFN92564 1015171-69-3 C27H24O10 = 508.5 5mg QQ客服:3257982914
    异丹酚酸C; Isosalvianolic acid C CFN92565 142115-17-1 C26H20O10 = 492.4 5mg QQ客服:215959384
    丹酚酸C; Salvianolic acid C CFN98553 115841-09-3 C26H20O10 = 492.44 20mg QQ客服:215959384
    紫草酸; Lithospermic acid CFN98546 28831-65-4 C27H22O12 = 538.46 20mg QQ客服:3257982914

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