Info: Read More
    		•
  • 中药标准品生产商，产品定制服务
    		•
  • 首页
  • 天然产物
  • 产品文献
  • 最新产品
  • 订购流程
  • 公司新闻
  • 公司简介
  • 联系我们
  • 首页
  • /
  • 天然产物（标准品）
  • /
  • 7-乙基-10-羟基喜树碱

    • 7-乙基-10-羟基喜树碱

    7-Ethyl-10-Hydroxycamptothecin

    7-乙基-10-羟基喜树碱
    		产品编号 CFN90335
    CAS编号 86639-52-3
    分子式 = 分子量 C22H20N2O5 = 392.4
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Alkaloids
    植物来源 The barks of Camptotheca acuminata Decne.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7-乙基-10-羟基喜树碱 CFN90335 86639-52-3 10mg QQ客服：1457312923
    7-乙基-10-羟基喜树碱 CFN90335 86639-52-3 20mg QQ客服：1457312923
    7-乙基-10-羟基喜树碱 CFN90335 86639-52-3 50mg QQ客服：1457312923
    7-乙基-10-羟基喜树碱 CFN90335 86639-52-3 100mg QQ客服：1457312923
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

    2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。 但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常，这些可用于长达两周。 使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话：
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到：027-84254680

    • 提供订购信息
  • 为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号（CAS No.或产品名称）
  • 2. 发货地址
  • 3. 联系方法 (联系人，电话）
  • 4. 开票抬头 (如果需要发票的客户）
  • 5. 发票地址（发货地址与发票地址不同）
    • 发货时间
    1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Uniwersytet Gdański (Poland)
  • MTT Agrifood Research Finland (Finland)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Sri Ramachandra University (India)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Copenhagen University (Denmark)
  • Chulalongkorn University (Thailand)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Almansora University (Egypt)
  • National Cancer Center Research Institute (Japan)
  • University of Padjajaran (Indonesia)
  • Universidad Miguel Hernández (Spain)
  • University of Minnesota (USA)
  • Michigan State University (USA)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Genes Genomics.2020, 10.1007
  • Applied Biological Chemistry2022, 65(77).
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Nutrients.2018, 11(1):E17
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • Foods2023, 12(23), 4342.
  • J Chromatogr A.2022, 1685:463640.
  • Rev. Chim.2020, 71(3),558-564
  • Mol Cells.2018, 41(8):771-780
  • Talanta.2022, 249:123645.
  • Pharmaceutics.2020, 12(9):882.
  • Natural Product Communications2020, doi: 10.1177.
  • Processes 2021, 9(5),894.
  • Phytomedicine.2018, 41:62-66
  • Applied Physics B2021, 127(92).
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Molecules.2023, 28(3):958.
  • J Applied Biological Chemistry2021, 64(2):185-192
  • Phytomedicine.2021, 83:153483.
  • ACS Omega.2021, 6(36):23460-23474.
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • PLoS One.2021, 16(9):e0257243.
  • Int J Mol Sci.2018, 19(2)
  • ...
    • 生物活性
    Description: 7-Ethyl-10-hydroxycamptothecin shows cytotoxicity against breast cancer, it efficiently target-bind to the colon and lungs of mice.
    Targets: P-gp
    In vitro:
    Nanotechnology. 2013 Jun 21;24(24):245101.
    Mechanisms of chitosan-coated poly(lactic-co-glycolic acid) nanoparticles for improving oral absorption of 7-ethyl-10-hydroxycamptothecin.[Pubmed: 23702815]
    Chitosan-modified poly(lactic-co-glycolic acid) nanoparticles (CHI/PLGA NPs) loaded with 7-Ethyl-10-Hydroxycamptothecin (SN-38), named CHI/PLGA/SN-38 NPs, were successfully prepared using an oil-in-water (O/W) solvent evaporation method.
    METHODS AND RESULTS:
    The physicochemical properties of the novel NPs were characterized by DLS, Zeta potential, SEM, DSC, XRD, and FTIR. The encapsulation efficiency and drug loading content were 71.83 (±2.77)% and 6.79 (±0.26)%, respectively. In vitro drug release in the simulated gastric juice was lower than that in the intestinal juice. In situ single-pass intestinal perfusion (SPIP) studies indicated a dramatic improvement of drug absorption as a result of the synergistic effect between CHI and PLGA on P-glycoprotein (Pgp) inhibition. CHI/PLGA NPs showed high cellular uptake and low efflux for drugs in Caco-2 cells. The cytotoxicity studies revealed that CHI/PLGA NPs had a transient effect on the membrane integrity, but did not have an influence on cell viability. Based on the in vitro release studies, SPIP, and intracellular drug accumulation and transport investigations, we speculate rationally that CHI/PLGA NPs were mainly internalized in the form of intact NPs, thus escaping the recognition of enterocyte Pgp and avoiding efflux into the apical part of the enterocytes. After partial release of drugs inside the enterocytes, CHI/PLGA interfered with the microenvironment of Pgp and further weakened the Pgp-mediated efflux. Then, the drug-loaded NPs exited via the exocytose effect from the basal part of the enterocytes and entered the blood circulation.
    CONCLUSIONS:
    These results showed that CHI/PLGA NPs would be smart oral delivery carriers for antineoplastic agents that are also Pgp substrates.
    In vivo:
    Yao Xue Xue Bao. 2014 Jul;49(7):1029-33.
    Pharmacokinetics of SN-38 in rats and tissue distribution of 7-ethyl-10-hydroxycamptothecin in mice after intravenous injection of irinotecan hydrochloride nanoparticles.[Pubmed: 25233635]
    The paper reported an investigation of the pharmacokinetics of SN-38 (7-Ethyl-10-Hydroxycamptothecin) in rats and the tissue distribution in mice after injection of irinotecan hydrochloride nanoparticles (CPT-11) via tail veins. An LC-MS/MS method was established to determine the concentrations of 7-Ethyl-10-Hydroxycamptothecin in whole blood of rats and in different tissues of mice.
    METHODS AND RESULTS:
    The pharmacokinetics and tissue distribution of 7-Ethyl-10-Hydroxycamptothecin were compared after the intravenous injection of CPT-11 NPs and CPT-11 solution. Compared with irinotecan solution, the elimination half-life of 7-Ethyl-10-Hydroxycamptothecin was prolonged from 2.17 h to 2.67 h after the intravenous injection of CPT-11 NPs, but its AUC had little change. After the injection of CPT-11 NPs in mice, over time, the concentrations of CPT-11-metabolized 7-Ethyl-10-Hydroxycamptothecin in CPT-11 NPs were significantly higher in the whole blood, colon and lungs than those in CPT-11 solution, followed by in the spleen and liver, but those in the heart and brain had no change. However, the amount of 7-Ethyl-10-Hydroxycamptothecin in the kidneys was reduced with time. CPT-11 NPs could prolong 7-Ethyl-10-Hydroxycamptothecin's (one of its metabolites) blood circulation time in rats and significantly increased the concentration of CPT-11-metabolized 7-Ethyl-10-Hydroxycamptothecin in the whole blood, colon and lungs of mice.
    CONCLUSIONS:
    CPT-11 NPs made 7-Ethyl-10-Hydroxycamptothecin efficiently target-bind to the colon and lungs of mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5484 mL 12.7421 mL 25.4842 mL 50.9684 mL 63.7105 mL
    5 mM 0.5097 mL 2.5484 mL 5.0968 mL 10.1937 mL 12.7421 mL
    10 mM 0.2548 mL 1.2742 mL 2.5484 mL 5.0968 mL 6.371 mL
    50 mM 0.051 mL 0.2548 mL 0.5097 mL 1.0194 mL 1.2742 mL
    100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.5097 mL 0.6371 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鲁比替康; Rubitecan CFN93013 91421-42-0 C20H15N3O6 = 393.35 5mg QQ客服：2159513211
    10-硝基喜树碱; 10-Nitro-camptothecin CFN90439 104195-61-1 C20H15N3O6 = 393.34 5mg QQ客服：1457312923
    盐酸拓扑替康; Topotecan hydrochloride CFN90462 119413-54-6 C23H24ClN3O5 = 457.9 20mg QQ客服：3257982914
    盐酸依立替康; Irinotecan hydrochloride CFN90886 100286-90-6 C33H39ClN4O6 = 623.2 20mg QQ客服：1457312923
    7-乙基喜树碱; 7-Ethylcamptothecin CFN90336 78287-27-1 C22H20N2O4 = 376.41 20mg QQ客服：3257982914
    7-乙基-10-羟基喜树碱; 7-Ethyl-10-Hydroxycamptothecin CFN90335 86639-52-3 C22H20N2O5 = 392.4 20mg QQ客服：2159513211
    9-甲氧基喜树碱; 9-Methoxycamptothecine CFN99729 39026-92-1 C21H18N2O5 = 378.38 20mg QQ客服：1413575084
    9-氨基喜树碱; 9-Aminocamptothecin CFN90309 91421-43-1 C20H17N3O4 = 363.37 20mg QQ客服：215959384
    (S)-10-羟基喜树碱; (S)-10-Hydroxycamptothecin CFN99735 19685-09-7 C20H16N2O5 = 364.35 20mg QQ客服：3257982914
    10-甲氧基喜树碱; 10-Methoxycamptothecin CFN90157 19685-10-0 C21H18N2O5 = 378.38 5mg QQ客服：2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

    联系方式


    电机：027-84237783
    传真：027-84254680
    在线QQ: 1413575084
    E-Mail：manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。