7,3'-二羟基-5'-甲氧基异黄酮

7,3'-Dihydroxy-5'-methoxyisoflavone

	产品编号	CFN92389
	CAS编号	947611-61-2
	分子式 = 分子量	C₁₆H₁₂O₅ = 284.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The rhizomes of Polygonatum kingianum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7,3'-二羟基-5'-甲氧基异黄酮	CFN92389	947611-61-2	1mg	QQ客服：2159513211
7,3'-二羟基-5'-甲氧基异黄酮	CFN92389	947611-61-2	5mg	QQ客服：2159513211
7,3'-二羟基-5'-甲氧基异黄酮	CFN92389	947611-61-2	10mg	QQ客服：2159513211
7,3'-二羟基-5'-甲氧基异黄酮	CFN92389	947611-61-2	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universiti Putra Malaysia(UPM) (Malaysia)

University of Helsinki (Finland)

Gyeongsang National University (Korea)

Pennsylvania State University (USA)

National Research Council of Canada (Canada)

University of Fribourg (Switzerland)

University of Melbourne (Australia)

Mendel University in Brno (Czech Republic)

Imperial College London (United Kingdom)

Uniwersytet Gdański (Poland)

Complutense University of Madrid (Spain)

Universidade Federal de Goias (UFG) (Brazil)

University of British Columbia (Canada)

Chungnam National University (Korea)

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Description:

7,3'-Dihydroxy-5'-methoxyisoflavone shows moderate activity against the renal, melanoma and breast cancer cell lines, it may have a synergistic effect with other anticancer drugs.

In vitro:

Afr J Tradit Complement Altern Med. 2014 Aug 23;11(5):33-7.

Isoflavones from Calpurnia Aurea subsp. aurea and their anticancer activity.[Pubmed: 25395701]

Calpurnia aurea is an African medicinal plant used in many countries in Africa to treat a range of medical conditions or disorders. Extracts of the plant were shown to be active in antibacterial and antioxidant assays as well as against lice, ticks and maggots. The aim of the study was to isolate the phytochemical constituents from the plant and to test them in appropriate bioassays dependent on the compounds isolated in order to provide a rationale for the use of the plant in ethno-medicine or to provide some information on its constituents.
METHODS AND RESULTS:
The stem and bark of the plant was extracted with organic solvents of varying polarity and the extracts separated and purified using column chromatography. The isolated compounds were identified by NMR spectroscopy and the compounds were tested for their in vitro anticancer activity against breast (MCF7), renal (TK10) and melanoma (UACC62) human cell lines using an in house method developed at the CSIR, South Africa. The isoflavones, 4',5,7-trihydroxyisoflavone (1), 7,3'-dihydroxy-5'-methoxyisoflavone (2), 7-hydroxy-4',8-dimethoxyisoflavone (3), 7-acetoxy-4',8-dimethoxyisoflavone (4) and 3',7-dihydroxy-4',8-dimethoxyisoflavone (5), a pterocarpan (3-acetoxy-9-methoxypterocarpan) and a quinolizidine alkaloid (calpurnine) were isolated from the stem and bark of Calpurnia aurea. The tetrasubstituted isoflavone 5 was found to be the most active in the three cell lines amongst all the compounds tested. This was followed by trisubstituted isoflavone 2.
CONCLUSIONS:
The isoflavones showed moderate activity against the renal, melanoma and breast cancer cell lines tested against, with the isoflavones 2 and 5 showing the best activity of the compounds tested. These isoflavones may have a synergistic effect with other anticancer drugs.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3',4',5,7-四羟基异黄酮; Orobol	CFN98737	480-23-9	C₁₅H₁₀O₆ = 286.2	5mg	QQ客服：2159513211
3'-O-甲基香豌豆苷元; 3'-O-Methylorobol	CFN98492	36190-95-1	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：215959384
7,3'-二-O-甲基奥洛波尔; 7,3'-Di-O-methylorobol	CFN96518	104668-88-4	C₁₇H₁₄O₆ = 314.30	5mg	QQ客服：1457312923
红车轴草素; Pratensein	CFN90805	2284-31-3	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：1413575084
5-Hydroxypseudobaptigenin; 5-Hydroxypseudobaptigenin	CFN91501	40624-03-1	C₁₆H₁₀O₆ = 298.3	5mg	QQ客服：1413575084
刺桐素 H; Erythrinin H	CFN96559	1616592-62-1	C₁₇H₁₂O₇ = 328.28	5mg	QQ客服：3257982914
次野鸢尾黄素; Irisflorentin	CFN99788	41743-73-1	C₂₀H₁₈O₈ = 386.35	20mg	QQ客服：2159513211
野鸢尾黄素; Irigenin	CFN93276	548-76-5	C₁₈H₁₆O₈ = 360.31	20mg	QQ客服：3257982914
Isolupalbigenin; Isolupalbigenin	CFN96522	162616-70-8	C₂₅H₂₆O₅ = 406.48	5mg	QQ客服：2159513211
Isoangustone A; Isoangustone A	CFN96505	129280-34-8	C₂₅H₂₆O₆ = 422.47	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5174 mL	17.5871 mL	35.1741 mL	70.3482 mL	87.9353 mL
5 mM	0.7035 mL	3.5174 mL	7.0348 mL	14.0696 mL	17.5871 mL
10 mM	0.3517 mL	1.7587 mL	3.5174 mL	7.0348 mL	8.7935 mL
50 mM	0.0703 mL	0.3517 mL	0.7035 mL	1.407 mL	1.7587 mL
100 mM	0.0352 mL	0.1759 mL	0.3517 mL	0.7035 mL	0.8794 mL