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  • 6-脱氧巴西红厚壳素

    6-Deoxyjacareubin

    6-脱氧巴西红厚壳素
    产品编号 CFN96276
    CAS编号 16265-56-8
    分子式 = 分子量 C18H14O5 = 310.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Xanthones
    植物来源 The stems and roots of Hypericum brasiliense.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    6-脱氧巴西红厚壳素 CFN96276 16265-56-8 1mg QQ客服:3257982914
    6-脱氧巴西红厚壳素 CFN96276 16265-56-8 5mg QQ客服:3257982914
    6-脱氧巴西红厚壳素 CFN96276 16265-56-8 10mg QQ客服:3257982914
    6-脱氧巴西红厚壳素 CFN96276 16265-56-8 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Perugia (Italy)
  • University of Zurich (Switzerland)
  • Osmania University (India)
  • Chulalongkorn University (Thailand)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Chinese University of Hong Kong (China)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • The Ohio State University (USA)
  • National Research Council of Canada (Canada)
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  • University of Helsinki (Finland)
  • Universidad Veracuzana (Mexico)
  • University of the Basque Country (Spain)
  • Universidade do Porto (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Res Int.2020, 133:109130.
  • Arch Biochem Biophys.2020, 687:108384.
  • Journal of Food and Drug Analysis2023, 31(3), 9.
  • Plants (Basel).2021, 10(7):1376.
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Current Pharmaceutical Analysis2017, 13(5)
  • Industrial Crops and Products2019, 140:111612
  • Plant Archives2020, 2(1),2929-2934
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • Molecules.2021, 26(16):4722.
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • Anticancer Res.2018, 38(4):2127-2135
  • Toxicol Appl Pharmacol.2022, 434:115815.
  • Eur J Pharmacol.2022, 917:174744.
  • Molecules.2019, 24(17):E3127
  • Horticulturae2021, 7(1),5.
  • Research Square2023, 2883170.
  • J Ethnopharmacol.2020, 269:113752.
  • J Ethnopharmacol.2023, 321:117501.
  • Functional Ecology2020, doi: 10.1111.
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Biochem Biophys Res Commun.2021, 534:802-807.
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • ...
  • 生物活性
    Description: 6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.6-Deoxyjacareubin is antifungal against Cladosporium cucumerinum, while it shows differing degrees of inhibition of monoamine oxidase A and B. 6-Deoxyjacareubin shows strong platelet activating factor (PAF) receptor binding inhibitory effects using rabbit platelets with IC50 values of 29.0 microM, suggests that xanthones can represent a new class of natural PAF receptor antagonists.
    Targets: PAFR | Antifection
    In vitro:
    J Ethnopharmacol. 2001 May;75(2-3):287-90.
    Inhibitory effects of xanthones on platelet activating factor receptor binding in vitro.[Pubmed: 11297865]

    METHODS AND RESULTS:
    Nine naturally occurring xanthones were investigated for their platelet activating factor (PAF) receptor binding inhibitory effects using rabbit platelets. 2-(3-methylbut-2-enyl)-1,3,5-trihydoxyxanthone, macluraxanthone, 1,3,5-trihydroxy-6,6'-dimethylpyrano(2',3':6,7)-4-(1,1-dimethylprop-2-enyl)xanthone, 6-Deoxyjacareubin and 2-(3-methylbut-2-enyl)-1,3,5,6-terahydroxyxanthone showed strong inhibition with IC50 values of 4.8, 11.0, 21.0, 29.0 and 44.0 microM, respectively. The prenyl group at C-2, the dimethylprop-2-enyl group at C-4 and the hydroxyl group at C-5 are all beneficial to the binding of xanthones to the PAF receptor.
    CONCLUSIONS:
    The results revealed that xanthones can represent a new class of natural PAF receptor antagonists.
    Molecules. 2011 Dec 7;16(12):10157-67.
    Antioxidant phenolic compounds of cassava (Manihot esculenta) from Hainan[Pubmed: 22157579]

    METHODS AND RESULTS:
    An activity-directed fractionation and purification process was used to isolate antioxidant components from cassava stems produced in Hainan. The ethyl acetate and n-butanol fractions showed greater DPPH˙and ABTS·+ scavenging activities than other fractions. The ethyl acetate fraction was subjected to column chromatography, to yield ten phenolic compounds: Coniferaldehyde (1), isovanillin (2), 6-Deoxyjacareubin (3), scopoletin (4), syringaldehyde (5), pinoresinol (6), p-coumaric acid (7), ficusol (8), balanophonin (9) and ethamivan (10), which possess significant antioxidant activities. The relative order of DPPH· scavenging capacity for these compounds was ascorbic acid (reference) > 6 > 1 > 8 > 10 > 9 > 3 > 4 > 7 > 5 > 2, and that of ABTS·+ scavenging capacity was 5 > 7 > 1 > 10 > 4 > 6 > 8 > 2 > Trolox (reference compound) > 3 > 9.
    CONCLUSIONS:
    The results showed that these phenolic compounds contributed to the antioxidant activity of cassava.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2227 mL 16.1134 mL 32.2269 mL 64.4538 mL 80.5672 mL
    5 mM 0.6445 mL 3.2227 mL 6.4454 mL 12.8908 mL 16.1134 mL
    10 mM 0.3223 mL 1.6113 mL 3.2227 mL 6.4454 mL 8.0567 mL
    50 mM 0.0645 mL 0.3223 mL 0.6445 mL 1.2891 mL 1.6113 mL
    100 mM 0.0322 mL 0.1611 mL 0.3223 mL 0.6445 mL 0.8057 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,4-二氢-7,10-二羟基-12-甲氧基-2,2-二甲基-2H,6H-吡喃并[3,2-b]氧杂蒽-6-酮; Garcinexanthone A CFN99206 1107620-67-6 C19H18O6 = 342.4 5mg QQ客服:1457312923
    7-Prenyljacareubin; 7-Prenyljacareubin CFN89056 94513-60-7 C23H22O6 = 394.42 5mg QQ客服:215959384
    Pyranojacareubin; Pyranojacareubin CFN89137 78343-62-1 C23H20O6 = 392.40 5mg QQ客服:1413575084
    1,3,5-三羟基-4-异戊烯基氧杂蒽酮; 1,3,5-Trihydroxy-4-prenylxanthone CFN98891 53377-61-0 C18H16O5 = 312.3 5mg QQ客服:2056216494
    6-Deoxyisojacareubin; 6-Deoxyisojacareubin CFN89446 26486-92-0 C18H14O5 = 310.30 5mg QQ客服:3257982914
    Ugaxanthone; Ugaxanthone CFN96469 13179-11-8 C18H16O6 = 328.32 5mg QQ客服:2056216494
    异巴西红厚壳素 ; Isojacareubin CFN96573 50597-93-8 C18H14O6 = 326.31 5mg QQ客服:2056216494
    1,3,6,8-tetrahydroxy-4-(3-methyl-2-buten-1-yl)-9H-Xanthen-9-one; 1,3,6,8-tetrahydroxy-4-(3-methyl-2-buten-1-yl)-9H-Xanthen-9-one CFN92541 1319198-98-5 C18H16O6 = 328.3 5mg QQ客服:215959384
    6-脱氧巴西红厚壳素; 6-Deoxyjacareubin CFN96276 16265-56-8 C18H14O5 = 310.3 5mg QQ客服:3257982914
    1,3,7-三羟基-2-异戊烯基氧杂蒽酮; 1,3,7-Trihydroxy-2-prenylxanthone CFN98022 20245-39-0 C18H16O5 = 312.3 5mg QQ客服:2056216494

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