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    5-甲基-7-甲氧基异黄酮

    5-Methyl-7-methoxyisoflavone

    5-甲基-7-甲氧基异黄酮
    产品编号 CFN93022
    CAS编号 82517-12-2
    分子式 = 分子量 C17H14O3 = 266.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Citrus aurantium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5-甲基-7-甲氧基异黄酮 CFN93022 82517-12-2 1mg QQ客服:2056216494
    5-甲基-7-甲氧基异黄酮 CFN93022 82517-12-2 5mg QQ客服:2056216494
    5-甲基-7-甲氧基异黄酮 CFN93022 82517-12-2 10mg QQ客服:2056216494
    5-甲基-7-甲氧基异黄酮 CFN93022 82517-12-2 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • FORTH-IMBB (Greece)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Calcutta University (India)
  • Technical University of Denmark (Denmark)
  • Seoul National University of Science and Technology (Korea)
  • University of East Anglia (United Kingdom)
  • Cornell University (USA)
  • University of Illinois (USA)
  • University of Queensland (Australia)
  • Kyoto University (Japan)
  • University of Amsterdam (Netherlands)
  • VIT University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Pharm Biomed Anal.2016, 129:50-59
  • Mediators Inflamm.2016, 2016:7216912
  • Phytochemistry.2017, 141:162-170
  • Sci Rep.2017, 7:40345
  • J Nat Med.2017, 71(2):457-462
  • Anal Chim Acta.2018, 1039:162-171
  • PLoS One.2018, 13(11):e0208055
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Plant Physiol Biochem.2019, 144:355-364
  • Molecules.2019, 24(11):E2044
  • Molecules.2019, 24(20):3755
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Oncol Rep.2019, 41(4):2453-2463
  • Front Microbiol.2020, 11:583594.
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • Int J Med Sci.2020, 17(5):626-631
  • Korean J Dent Mater2020, 47(2):63-70.
  • Phytomedicine.2020, 79, 153351
  • Korean Herb. Med. Inf.2020, 8(2):233-242.
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • ...
  • 生物活性
    Description: 5-Methyl-7-methoxyisoflavone is used by bodybuilders for its ergogenic properties.
    In vitro:
    Sci Rep. 2017 Apr 7;7:45780.
    A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials.[Pubmed: 28387380 ]
    There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease.
    METHODS AND RESULTS:
    We established a multi-tiered platform for the sequential screening of drugs that could be repurposed as remyelinating agents. We screened a library of 2,000 compounds (mainly Food and Drug Administration (FDA)-approved compounds and natural products) for cellular metabolic activity on mouse oligodendrocyte precursors (OPC), identifying 42 molecules with significant stimulating effects. We then characterized the effects of these compounds on OPC proliferation and differentiation in mouse glial cultures, and on myelination and remyelination in organotypic cultures. Three molecules, edaravone, 5-Methyl-7-methoxyisoflavone and lovastatin, gave positive results in all screening tiers. We validated the results by retesting independent stocks of the compounds, analyzing their purity, and performing dose-response curves. To identify the chemical features that may be modified to enhance the compounds' activity, we tested chemical analogs and identified, for edaravone, the functional groups that may be essential for its activity.
    CONCLUSIONS:
    Among the selected remyelinating candidates, edaravone appears to be of strong interest, also considering that this drug has been approved as a neuroprotective agent for acute ischemic stroke and amyotrophic lateral sclerosis in Japan.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7553 mL 18.7765 mL 37.553 mL 75.1061 mL 93.8826 mL
    5 mM 0.7511 mL 3.7553 mL 7.5106 mL 15.0212 mL 18.7765 mL
    10 mM 0.3755 mL 1.8777 mL 3.7553 mL 7.5106 mL 9.3883 mL
    50 mM 0.0751 mL 0.3755 mL 0.7511 mL 1.5021 mL 1.8777 mL
    100 mM 0.0376 mL 0.1878 mL 0.3755 mL 0.7511 mL 0.9388 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    樱黄素; Prunetin CFN90189 552-59-0 C16H12O5 = 284.26 20mg QQ客服:1413575084
    6-Methylgenistein; 6-Methylgenistein CFN96540 97575-49-0 C16H12O5 = 284.26 5mg QQ客服:2056216494
    6,7,4'-三羟基异黄酮; 6,7,4'-Trihydroxyisoflavone CFN90796 17817-31-1 C15H10O5 = 270.2 10mg QQ客服:3257982914
    黄豆黄素; Glycitein CFN99106 40957-83-3 C16H12O5 = 284.26 20mg QQ客服:2159513211
    Afrormosine; Afrormosine CFN92347 550-79-8 C17H14O5 = 298.3 5mg QQ客服:2932563308
    鸢尾黄素; Tectorigenin CFN99920 548-77-6 C16H12O6 = 300.26 20mg QQ客服:2932563308
    甘草宁N; Gancaonin N CFN95066 129145-52-4 C21H20O6 = 368.4 5mg QQ客服:2056216494
    甘草宁 G; Gancaonin G CFN96524 126716-34-5 C21H20O5 = 352.39 5mg QQ客服:1413575084
    刺桐素 G; Erythrinin G CFN96545 1616592-61-0 C20H18O6 = 354.35 5mg QQ客服:3257982914
    刺桐素 F; Erythrinin F CFN96549 1616592-60-9 C20H18O7 = 370.35 5mg QQ客服:1413575084

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