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  • 5-羟基-7,8-二甲氧基黄烷酮

    5-Hydroxy-7,8-dimethoxyflavanone

    5-羟基-7,8-二甲氧基黄烷酮
    产品编号 CFN99241
    CAS编号 113981-49-0
    分子式 = 分子量 C17H16O5 = 300.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Andrographis paniculata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5-羟基-7,8-二甲氧基黄烷酮 CFN99241 113981-49-0 1mg QQ客服:3257982914
    5-羟基-7,8-二甲氧基黄烷酮 CFN99241 113981-49-0 5mg QQ客服:3257982914
    5-羟基-7,8-二甲氧基黄烷酮 CFN99241 113981-49-0 10mg QQ客服:3257982914
    5-羟基-7,8-二甲氧基黄烷酮 CFN99241 113981-49-0 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Yale University (USA)
  • The Ohio State University (USA)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Oslo (Norway)
  • Weizmann Institute of Science (Israel)
  • Celltrion Chemical Research Institute (Korea)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Periyar University (India)
  • Universidade do Porto (Portugal)
  • University of Limpopo (South Africa)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Kyoto University (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl. Sci.2020, 10(5),1713.
  • BMC Complement Altern Med.2019, 19(1):339
  • Antioxidants (Basel).2022, 11(12):2327.
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • Life Sci.2023, 317:121458.
  • Molecules.2023, 28(19):6775.
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Front Pharmacol.2019, 10:1226
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Nat Commun.2019, 10(1):5169
  • ScientificWorldJournal.2022, 2022:4806889.
  • Front Pharmacol.2022, 13:906763.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Molecules.2018, 23(11):E2837
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Phytomedicine.2019, 59:152785
  • Molecules.2018, 23(2)
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Molecules.2019, 24(19):E3417
  • PLoS One.2022, 17(4):e0267007.
  • Molecules2022, 27(11):3606.
  • Phytother Res.2019, 33(7):1784-1793
  • Pharmaceuticals (Basel).2021, 14(10):1046.
  • ...
  • 生物活性
    Description: 5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells. (2S)-5-Hydroxy-7,8-dimethoxyflavanone is weakly active against human nasopharyngeal carcinoma cell line (KB) with IC50 value at 12.86 ug/ml.
    Targets: TNF-α | IL Receptor | NO | NF-kB | HIV | MIP
    In vitro:
    Parasitol Res. 2014 Sep;113(9):3381-92. Epub 2014 Jul 13.
    cture–function relationships of inhibition of mosquito cytochrome P450 enzymes by flavonoids of Andrographis paniculata.[Pubmed: 25015047]
    The cytochrome P450 monooxygenases are known to play a major role in pyrethroid resistance, by means of increased rate of insecticide detoxification as a result of their overexpression. Inhibition of detoxification enzymes may help disrupting insect detoxifying defense system. The Anopheles minimus CYP6AA3 and CYP6P7 have shown pyrethroid degradation activity and been implicated in pyrethroid resistance.
    METHODS AND RESULTS:
    In this study inhibition of the extracts and constituents of Andrographis paniculata Nees. leaves and roots was examined against benzyloxyresorufin O-debenzylation (BROD) of CYP6AA3 and CYP6P7. Four purified flavones (5,7,4′-trihydroxyflavone, 5-hydroxy-7,8-dimethoxyflavone, 5-hydroxy-7,8,2′,3′-tetramethoxyflavone, and 5,4′-dihydroxy-7,8,2′,3′-tetramethoxyflavone), one flavanone (5-Hydroxy-7,8-dimethoxyflavanone) and a diterpenoid (14-deoxy-11,12-didehydroandrographolide) containing inhibitory effects toward both enzymes were isolated from A. paniculata. Structure–function relationships were observed for modes and kinetics of inhibition among flavones, while diterpenoid and flavanone were inferior to flavones. Docking of flavones onto enzyme homology models reinforced relationships on flavone structures and inhibition modes. Cell-based inhibition assays employing 3-(4,5-dimethylthiazol-2-y-l)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assays revealed that these flavonoids efficiently increased susceptibility of CYP6AA3- and CYP6P7-expressing Spodoptera frugiperda (Sf9) cells to cypermethrin toxicity, due to inhibition effects on mosquito enzymes.
    CONCLUSIONS:
    Thus synergistic effects on cypermethrin toxicity of A. paniculata compounds as a result of enzyme inhibition could be useful for mosquito vector control and insecticide resistance management in the future.
    J Agric Food Chem. 2010 Feb 24;58(4):2505-12.
    Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition.[Pubmed: 20085279]
    Previous studies showed that the ethyl acetate (EtOAc) fraction of Andrographis paniculata (AP) possessed anti-inflammatory activity.
    METHODS AND RESULTS:
    This study further isolated these active compounds from bioactivity-guided chromatographic fractionation and identified eight pure compounds. Reporter gene assay indicated that 5-hydroxy-7,8-dimethoxyflavone (1), 5-Hydroxy-7,8-dimethoxyflavanone (2), a mix of beta-sitosterol (3a) and stigmasterol (3b), ergosterol peroxide (4), 14-deoxy-14,15-dehydroandrographolide (5), and a new compound, 19-O-acetyl-14-deoxy-11,12-didehydroandrographolide (6a), significantly inhibited the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages (P < 0.05). The two most abundant compounds, 14-deoxy-11,12-didehydroandrographolide (7) and andrographolide (8), had less inhibitory activity but exerted greater inhibitory activity by hydrogenation, oxidation, or acetylation to become four derived compounds, 9, 10, 11, and 12.
    CONCLUSIONS:
    All of the compounds significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells. Compounds 5, 11, and 12 exerted the strongest inhibitory effect on NF-kappaB-dependent transactivation in the RAW 264.7 cell, with IC(50) values of 2, 2.2, and 2.4 microg/mL, respectively, providing encouraging results for bioactive compound development.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    球松素; 乔松酮; Pinostrobin CFN98739 480-37-5 C16H14O4 = 270.3 20mg QQ客服:3257982914
    山姜素; Alpinetin CFN98489 36052-37-6 C16H14O4 = 270.3 20mg QQ客服:1413575084
    5,7-二甲氧基黄烷酮; 5,7-Dimethoxyflavanone CFN92662 1036-72-2 C17H16O4 = 284.3 5mg QQ客服:2159513211
    (2R)-5,7-Dimethoxyflavanone; (2R)-5,7-Dimethoxyflavanone CFN90899 1277188-85-8 C17H16O4 = 284.31 5mg QQ客服:1413575084
    二氢黄芩素; Dihydrobaicalein CFN93796 35683-17-1 C15H12O5 = 272.3 5mg QQ客服:1457312923
    二氢木蝴蝶素A; Dihydrooroxylin A CFN92591 18956-18-8 C16H14O5 = 286.3 5mg QQ客服:1413575084
    5-羟基-6,7-二甲氧基黄烷酮; Onysilin CFN92422 73695-94-0 C17H16O5 = 300.3 5mg QQ客服:3257982914
    5-羟基-7,8-二甲氧基黄烷酮; 5-Hydroxy-7,8-dimethoxyflavanone CFN99241 113981-49-0 C17H16O5 = 300.3 5mg QQ客服:2159513211
    7-羟基-5,8-二甲氧基黄烷酮; 7-Hydroxy-5,8-dimethoxyflavanone CFN98910 54377-24-1 C17H16O5 = 300.3 5mg QQ客服:2056216494
    8-羟基-5,7-二甲氧基黄烷酮; 8-Hydroxy-5,7-dimethoxyflavanone CFN95580 201230-40-2 C17H16O5 = 300.3 5mg QQ客服:1413575084

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