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  • 5,7-二甲氧基黄烷酮

    5,7-Dimethoxyflavanone

    5,7-二甲氧基黄烷酮
    产品编号 CFN92662
    CAS编号 1036-72-2
    分子式 = 分子量 C17H16O4 = 284.3
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Flavonoids
    植物来源 The stem barks of Uvaria mocoli
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5,7-二甲氧基黄烷酮 CFN92662 1036-72-2 1mg QQ客服:2159513211
    5,7-二甲氧基黄烷酮 CFN92662 1036-72-2 5mg QQ客服:2159513211
    5,7-二甲氧基黄烷酮 CFN92662 1036-72-2 10mg QQ客服:2159513211
    5,7-二甲氧基黄烷酮 CFN92662 1036-72-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Deutsches Krebsforschungszentrum (Germany)
  • Mahidol University (Thailand)
  • Nanjing University of Chinese Medicine (China)
  • National Cancer Center Research Institute (Japan)
  • University of Ioannina (Greece)
  • Worcester Polytechnic Institute (USA)
  • Chinese University of Hong Kong (China)
  • University of Wuerzburg (Germany)
  • Sanford Burnham Medical Research Institute (USA)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Medical University of Gdansk (Poland)
  • University of Madras (India)
  • Warszawski Uniwersytet Medyczny (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(7):E1290
  • J Pharmaceut Biomed2020, 182:113110
  • J Appl Biol Chem2021, 64(3):245-251.
  • Nutrients.2017, 10(1)
  • Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
  • Phytomedicine.2018, 47:48-57
  • Metabolites.2020, 11(1):E11.
  • Biomimetics (Basel).2022, 7(4):154.
  • J Pharmacol Sci.2021, 147(2):184-191.
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • Pak J Pharm Sci.2019, 32(6)
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Nutrients.2021, 13(12):4364.
  • Food Res Int.2017, 96:40-45
  • Plant Physiol Biochem.2021, 160:166-174.
  • Biomed Chromatogr.2020, e5021.
  • Food Chem.2022, 378:131975.
  • Eur J Pharmacol.2021, 906:174220.
  • Chem Biol Interact.2019, 315:108910
  • Front Pharmacol.2018, 9:756
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Vietnam Journal of Food Control.2022, 5(2): 115-128.
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • ...
  • 生物活性
    Description: 5,7-Dimethoxyflavanone has anti-inflammatory activities.
    Targets: TNF-α | NO | IL Receptor | IFN-γ
    In vitro:
    J Ethnopharmacol. 2005 Sep 14;100(3):249-53.
    Anti-inflammatory activities of flavonoids isolated from Caesalpinia pulcherrima.[Pubmed: 15893896]

    METHODS AND RESULTS:
    The anti-inflammatory activities of five flavonoids, namely 5,7-Dimethoxyflavanone (1), 5,7-dimethoxy-3',4'-methylenedioxyflavanone (2), isobonducellin (3), 2'-hydroxy-2,3,4',6'-tetramethoxychalcone (4) and bonducellin (5), all of them isolated from Caesalpinia pulcherrima L. was studied in lipopolysaccharide (LPS) and interferon (IFN)-gamma activated murine peritoneal macrophages. These five compounds significantly and dose-dependently inhibited the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. According to their inhibitory results, the order of anti-inflammatory potency was compounds 3>5>4>2>1. Furthermore, peritoneal macrophages were pre-activated with LPS/IFN-gamma for 24h, and determined the inhibitory effects of the above-mentioned isolates on the production of NO after a further 24h.
    CONCLUSIONS:
    The present study supports the use of Caesalpinia pulcherrima for the treatment of inflammatory diseases in traditional medicine. This is the first study on compounds 1-5 about their anti-inflammatory activities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5174 mL 17.5871 mL 35.1741 mL 70.3482 mL 87.9353 mL
    5 mM 0.7035 mL 3.5174 mL 7.0348 mL 14.0696 mL 17.5871 mL
    10 mM 0.3517 mL 1.7587 mL 3.5174 mL 7.0348 mL 8.7935 mL
    50 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.407 mL 1.7587 mL
    100 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.7035 mL 0.8794 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-羟基黄烷酮; 7-Hydroxyflavanone CFN94487 6515-36-2 C15H12O3 = 240.26 20mg QQ客服:2056216494
    松属素; 乔松素; Pinocembrin CFN98740 480-39-7 C15H12O4 = 256.3 20mg QQ客服:215959384
    7-乙酸-5,7-二羟基二氢黄酮酯; Pinocembrin 7-acetate CFN99096 109592-60-1 C17H14O5 = 298.3 5mg QQ客服:2159513211
    二乙酸松属素酯; Pinocembrin diacetate CFN99211 111441-88-4 C19H16O6 = 340.3 5mg QQ客服:1457312923
    球松素; 乔松酮; Pinostrobin CFN98739 480-37-5 C16H14O4 = 270.3 20mg QQ客服:1413575084
    山姜素; Alpinetin CFN98489 36052-37-6 C16H14O4 = 270.3 20mg QQ客服:1413575084
    5,7-二甲氧基黄烷酮; 5,7-Dimethoxyflavanone CFN92662 1036-72-2 C17H16O4 = 284.3 5mg QQ客服:1457312923
    (2R)-5,7-Dimethoxyflavanone; (2R)-5,7-Dimethoxyflavanone CFN90899 1277188-85-8 C17H16O4 = 284.31 5mg QQ客服:2056216494
    二氢黄芩素; Dihydrobaicalein CFN93796 35683-17-1 C15H12O5 = 272.3 5mg QQ客服:1413575084
    二氢木蝴蝶素A; Dihydrooroxylin A CFN92591 18956-18-8 C16H14O5 = 286.3 5mg QQ客服:1457312923

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