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  • 4-甲氧基肉桂酸

    4-Methoxycinnamic acid

    4-甲氧基肉桂酸
    产品编号 CFN98191
    CAS编号 830-09-1
    分子式 = 分子量 C10H10O3 = 178.18
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Phenylpropanoids
    植物来源 The barks of Cinnamomum cassia Presl.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4-甲氧基肉桂酸 CFN98191 830-09-1 10mg QQ客服:2159513211
    4-甲氧基肉桂酸 CFN98191 830-09-1 20mg QQ客服:2159513211
    4-甲氧基肉桂酸 CFN98191 830-09-1 50mg QQ客服:2159513211
    4-甲氧基肉桂酸 CFN98191 830-09-1 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Pennsylvania State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Engineering Progress2019, 23(3)209-216
  • ACS Pharmacol. Transl. Sci.2023, 3c00129.
  • Kor. J. Herbol.2019, 34(2):59-66
  • Sci Rep.2019, 9:12132
  • Evid-Based Compl Alt2020, 7202519:13
  • Sci. Rep.2015, 14-23
  • Molecules.2018, 23(11):E2837
  • Arch Pharm Res.2015, 38(6):1080-9
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Food and Fermentation Industries2018, 44(371)
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Sci Rep. 2017, 12953(7)
  • FASEB J.2022, 36(7):e22387.
  • Int J Mol Sci.2022, 23(21):12816.
  • Applied Physics B2021, 127(92).
  • Molecules.2022, 27(2):451.
  • Int Immunopharmacol. 2020, 83:106403.
  • Green Chemistry2021, ISSUE 2.
  • J Food Sci.2022, 87(11):4905-4916.
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • FASEB J.2019, 33(8):9685-9694
  • ...
  • 生物活性
    Description: 4-Methoxycinnamic acid is a photosensitive compound, it shows various pharmacologic actions such as anti-cancer, hepatoprotective and antihyperglycemic activities, it also can stimulate insulin secretion from pancreatic β-cells by increasing Ca2+ influx via the L-type Ca2+ channels, but not through the closure of ATP-sensitive K+ channels. 4-Methoxycinnamic acid can strongly inhibit the diphenolase activity of mushroom tyrosinase, with the IC 50 value of 0.42 mM, and the inhibition is reversible.
    Targets: Calcium Channel | ATPase | Potassium Channel | P450 (e.g. CYP17) | NADPH-oxidase
    In vitro:
    J Med Microbiol. 2011 Nov;60(Pt 11):1626-32.
    Natural products modulate Shigella-host-cell interaction.[Pubmed: 21719574]
    This study focused on identifying possible new options derived from natural sources for the treatment of bacterial infections. Several natural products were investigated for their potential in modulating Shigella-host-cell interactions.
    METHODS AND RESULTS:
    The proliferation of Shigella sonnei was effectively inhibited inside HEp-2 cells in the presence of 4-methoxycinnamic acid and propolin D. Propolin D also significantly reduced the apoptosis of infected macrophage-like U937 cells and moderately reduced the secretion of interleukin (IL)-1β and IL-18, which probably resulted from the inhibition of invasion plasmid antigen B secretion by this compound. Further characterization showed that propolin D did not prevent escape of Shigella from phagocytic vacuoles, as evidenced by actin-based motility and by the fact that addition of chloroquine did not further reduce the number of intracellular c.f.u. The role of propolin D in modulating autophagy could not be established under the experimental conditions used.
    CONCLUSIONS:
    As these compounds had no direct anti-Shigella activity in vitro, it was concluded that these compounds modulated Shigella-host-cell interactions by targeting yet-to-be defined mechanisms that provide benefits to host cells.
    US 8758864 B2[P]. 2014.
    Photosensitive semiconductor nanocrystals, photosensitive composition comprising semiconductor nanocrystals and method for forming semiconductor nanocrystal pattern using the same[Reference: WebLink]
    4. The organic-inorganic hybrid electroluminescent device according to claim 1, wherein the compound containing a photosensitive functional group is selected from a group consisting of methacrylic acid, crotonic acid, vinylacetic acid, tiglic acid, 3,3-dimethylacrylic acid, trans-2-pentenoic acid, 4-pentenoic acid, trans-2-methyl-2-pentenoic acid, 2,2-dimethyl-4-pentenoic acid, trans-2-hexenoic acid, trans-3-hexenoic acid, 2-ethyl-2-hexenoic acid, 6-heptenoic acid, 2-octenoic acid, citronellic acid, undecylenic acid, myristoleic acid, palmitoleic acid, oleic acid, elaidic acid, cis-11-elcosenoic acid, euric acid, nervonic acid, trans-2,4-pentadienoic acid, 2,4-hexadienoic acid, 2,6-heptadienoic acid, geranic acid, linoleic acid, 11,14-eicosadienoic acid, cis-8,11,14-eicosatrienoic acid, arachidonic acid, cis-5,8,11,14,17-eicosapentaenoic acid, cis-4,7,10,13,16,19-docosahexaenoic acid, fumaric acid, maleic acid, itaconic acid, ciraconic acid, mesaconic acid, trans-glutaconic acid, trans-beta-hydromuconic acid, trans-traumatic acid, trans-muconic acid, cis-aconitic acid, trans-aconitic acid, cis-3-chloroacrylic acid, trans-3-chloroacrylic acid, 2-bromoacrylic acid, 2-(trifluoromethyl)acryl-ic acid, trans-styrylacetic acid, trans-cinnamic acid, alpha.-methylcinnamic acid, 2-methylcinnamic acid, 2-fluorocinnamic acid, 2-(trifluoromethyl)cinnamic acid, 2-chlorocinnamic acid, 2-methoxycinnamic acid, 2-hydroxycinnamic acid, 2-nitrocinnamic acid, 2-carboxycinnamic acid, trans-3-fluorocinnamic acid, 3-(trifluoromethyl)cinnamic acid, 3-chlorocinnamic acid, 3-bromocinnamic acid, 3-methoxycinnamic acid, 3-hydroxycinnamic acid, 3-nitrocinnamic acid, 4-methylcinnamic acid, 4-fluorocinnamic acid, trans-4-(trifluoromethyl)-cinnamic acid, 4-chlorocinnamic acid, 4-bromocinnamic acid, 4-methoxycinnamic acid, 4-hydroxycinnamic acid, 4-nitrocinnamic acid, 3,3-dimethoxycinnamic acid, 4-vinylbenzoic acid, allyl methyl sulfide, allyl disulfide, diallyl amine, oleylamine, 3-amino-1-propanol vinyl ether, 4-chlorocinnamonitrile, 4-methoxycinnamonitrile, 3,4-dimethoxycinnamonitrile, 4-dimethylaminocinnamonitrile, acrylonitrile, allyl cyanide, crotononitrile, methacrylonitrile, cis-2-pentenenitrile, trans-3-pentenenitrile, 3,7-dimethyl-2,6-octadienenitrile, and 1,4-dicyano-2-butene.
    In vivo:
    Mol Cell Biochem. 2014 Sep;394(1-2):187-98.
    Protective effect of p-methoxycinnamic acid, an active phenolic acid against 1,2-dimethylhydrazine-induced colon carcinogenesis: modulating biotransforming bacterial enzymes and xenobiotic metabolizing enzymes.[Pubmed: 24908112 ]
    Objective of the study is to evaluate the modifying potential of p-methoxycinnamic acid (4-Methoxycinnamic acid,p-MCA), an active rice bran phenolic acid on biotransforming bacterial enzymes and xenobiotic metabolizing enzymes in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
    METHODS AND RESULTS:
    48 male albino wistar rats were divided into six groups. Group1 (control) received modified pellet diet and 0.1 % carboxymethylcellulose; group2 received modified pellet diet along with p-MCA (80 mg/kg b.wt. p.o.) everyday for 16 weeks; groups 3-6 received 1,2-dimethylhydrazine (DMH) (20 mg/kg b.wt.) subcutaneous injection once a week for the first 4 weeks, while groups 4-6 received p-MCA at three different doses of 20, 40 and 80 mg/kg b.wt. p.o. everyday for 16 weeks. A significant increase in carcinogen-activating enzymes (cytochrome P450, cytochrome b5, cytochrome P4502E1, NADH-cytochrome-b5-reductase and NADPH-cytochrome-P450 reductase) with concomitant decrease in phaseII enzymes, DT-Diaphorase, glutathione S-transferase, UDP-glucuronyl-transferase and gamma glutamyltransferase were observed in group3 compared to control. DMH treatment significantly increased the activities of feacal and colonic bacterial enzymes (β-glucosidase, β-galactosidase, β-glucuronidase, nitroreductase, sulphatase and mucinase). p-MCA supplementation (40 mg/kg b.wt) to carcinogen exposed rats inhibited these enzymes, which were near those of control rats.
    CONCLUSIONS:
    The formation of dysplastic aberrant crypt foci in the colon and the histopathological observations of the liver also supports our biochemical findings. p-MCA (40 mg/kg b.wt.) offers remarkable modulating efficacy of biotransforming bacterial and xenobiotic metabolizing enzymes in colon carcinogenesis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.6123 mL 28.0615 mL 56.123 mL 112.246 mL 140.3076 mL
    5 mM 1.1225 mL 5.6123 mL 11.2246 mL 22.4492 mL 28.0615 mL
    10 mM 0.5612 mL 2.8062 mL 5.6123 mL 11.2246 mL 14.0308 mL
    50 mM 0.1122 mL 0.5612 mL 1.1225 mL 2.2449 mL 2.8062 mL
    100 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1225 mL 1.4031 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Octyl 3-(4-hydroxyphenyl)prop-2-enoate; Octyl 3-(4-hydroxyphenyl)prop-2-enoate CFN95563 N/A C17H24O3 = 276.4 5mg QQ客服:3257982914
    3-(4-甲氧基苯基)丙酸甲酯; Methyl 3-(4-methoxyphenyl)propanoate CFN96152 15823-04-8 C11H14O3 = 194.2 5mg QQ客服:2056216494
    Ethyl 3-(4-methoxyphenyl)propanoate; Ethyl 3-(4-methoxyphenyl)propanoate CFN96138 22767-72-2 C12H16O3 = 208.3 5mg QQ客服:1457312923
    4-羟基苯基乳酸甲酯; Methyl p-hydroxyphenyllactate CFN96379 51095-47-7 C10H12O4 = 196.2 5mg QQ客服:2056216494
    3-(4-羟基苯基)乳酸乙酯; Ethyl p-hydroxyphenyllactate CFN96363 62517-34-4 C11H14O4 = 210.2 5mg QQ客服:2159513211
    3-(4-甲氧基苯基)-3-氧代丙酸; 4-Methoxybenzoylacetic acid CFN95446 13422-77-0 C10H10O4 = 194.2 5mg QQ客服:1413575084
    2,3-二羟基-3-(4-羟基苯基)丙酸; 2,3-dihydroxy-3-(4-hydroxyphenyl)propanoic acid CFN99018 100201-57-8 C9H10O5 = 198.2 5mg QQ客服:1413575084
    4-硝基肉桂酸; 4-Nitrocinnamic acid CFN98185 619-89-6 C9H7NO4 = 193.16 20mg QQ客服:1413575084
    4-氯肉桂酸; 4-Chlorocinnamic acid CFN98184 1615-02-7 C9H7ClO2 = 182.60 20mg QQ客服:1457312923
    2-氯肉桂酸; 2-Chlorocinnamic acid CFN98190 3752-25-8 C9H7ClO2 = 182.61 20mg QQ客服:3257982914

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