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  • 4,5-二氢布卢门醇A

    4,5-Dihydroblumenol A

    4,5-二氢布卢门醇A
    产品编号 CFN99657
    CAS编号 155418-97-6
    分子式 = 分子量 C13H22O3 = 226.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Rosa multiflora Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4,5-二氢布卢门醇A CFN99657 155418-97-6 1mg QQ客服:2159513211
    4,5-二氢布卢门醇A CFN99657 155418-97-6 5mg QQ客服:2159513211
    4,5-二氢布卢门醇A CFN99657 155418-97-6 10mg QQ客服:2159513211
    4,5-二氢布卢门醇A CFN99657 155418-97-6 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2021, 12:615157.
  • Foods. 2022, 11(23):3905.
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Food Chem.2022, 378:131975.
  • Antioxidants (Basel).2021, 10(8):1300.
  • Molecules.2019, 24(11):E2102
  • Foods2023, 12(23), 4342.
  • Front Neurosci.2019, 13:1091
  • Int J Mol Sci.2017, 19(1)
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Forensic Sci Int.2022, 341:111475.
  • Int Immunopharmacol.2023, 123:110572.
  • Food Res Int.2021, 148:110607.
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • Phytomedicine.2015, 22(11):1027-36
  • J Chromatogr A.2022, 1685:463640.
  • Sci Rep.2019, 9(1):4646
  • ...
  • 生物活性
    Description: 4, 5-Dihydroblumenol shows significant inhibition against HepG2 cells transected with cloned hepatitis B virus DNA.
    Targets: HBV
    In vitro:
    Molecules. 2008 Jun 1;13(6):1219-29.
    Identification of minor secondary metabolites from the latex of Croton lechleri (Muell-Arg) and evaluation of their antioxidant activity.[Pubmed: 18596648]
    Dragon's blood (Sangre de drago), a viscous red sap derived from Croton lechleri Muell-Arg (Euphorbiaceae), is extensively used by indigenous cultures of the Amazonian basin for its wound healing properties. The aim of this study was to identify the minor secondary metabolites and test the antioxidant activity of this sustance.
    METHODS AND RESULTS:
    A bioguided fractionation of the n-hexane, chloroform, n-butanol, and aqueous extracts led to the isolation of 15 compounds: three megastigmanes, four flavan-3-ols, three phenylpropanoids, three lignans, a clerodane, and the alkaloid taspine. In addition to these known molecules, six compounds were isolated and identified for the first time in the latex: blumenol B, blumenol C, 4,5-Dihydroblumenol A, erythro-guaiacyl-glyceryl-beta-O-4'- dihydroconiferyl ether, 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol and floribundic acid glucoside. Combinations of spectroscopic methods ((1)H-, (13)C- NMR and 2D-NMR experiments), ESI-MS, and literature comparisons were used for compound identification. In vitro antioxidant activities were assessed by DPPH, total antioxidant capacity and lipid peroxidation assays.
    CONCLUSIONS:
    Flavan-3-ols derivatives (as major phenolic compounds in the latex) exhibited the highest antioxidant activity.
    Chinese Traditional & Herbal Drugs, 2007, 38(7): 976-9.
    Antivirus constituents from Alternanthera philoxeroides.[Reference: WebLink]
    To investigate the anti-HBV constituents from Alternanthera philoxeroides.
    METHODS AND RESULTS:
    The constituents were isolated with silica gel and gel permeation chromatography,and purified by HPLC.Their structures were elucidated by spectroscopy.The antivirus effects of the isolated compounds were tested by ELISA method in vitro. Ten compounds were isolated and elucidated as followings:oleanolic acid(Ⅰ),oleanolic acid 3-O-β-D-glucuronopyranoside(Ⅱ),oleanolic acid 28-O-β-D-glucopyranoside(Ⅲ),chikusetsusaponin Ⅳ a methyl ester(Ⅳ),4,5-dihydroblumenol(Ⅴ),N-trans-feruloyl 3-methyldopamine(Ⅵ),N-trans-feruloyl tyramine(Ⅶ),3β-hydroxystigmast-5-en-7-one(Ⅷ),24-methylenecycloartanol(Ⅸ),and cycloeucalenol(Ⅹ).The values of inhibition percent of compounds Ⅰ-Ⅲ,Ⅴ-Ⅶ revealed a significant distinction compared to the control group.Compounds Ⅱ and Ⅴ showed significant inhibition against HepG2 cells transected with cloned hepatitis B virus DNA,their inhibitive ratios were 85.38% and 87.37% at 50 μg/mL,respectively.
    CONCLUSIONS:
    Compounds Ⅳ-Ⅶ are isolated from this plant for the first time and phenolic amides have been determined as the new structure type from the plants of Alternanthera Forsk.Compounds Ⅱ and Ⅴ from A.philoxeroides show the more significant anti-HBV activities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4189 mL 22.0946 mL 44.1891 mL 88.3783 mL 110.4728 mL
    5 mM 0.8838 mL 4.4189 mL 8.8378 mL 17.6757 mL 22.0946 mL
    10 mM 0.4419 mL 2.2095 mL 4.4189 mL 8.8378 mL 11.0473 mL
    50 mM 0.0884 mL 0.4419 mL 0.8838 mL 1.7676 mL 2.2095 mL
    100 mM 0.0442 mL 0.2209 mL 0.4419 mL 0.8838 mL 1.1047 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    布卢门醇C 葡糖苷; Blumenol C glucoside CFN99424 135820-80-3 C19H32O7 = 372.5 5mg QQ客服:2056216494
    4,5-二氢布卢门醇A; 4,5-Dihydroblumenol A CFN99657 155418-97-6 C13H22O3 = 226.3 5mg QQ客服:2159513211
    Unedone; Unedone CFN96466 1199815-09-2 C13H20O4 = 240.30 5mg QQ客服:2159513211
    布卢门醇B; Blumenol B CFN98491 36151-01-6 C13H22O3 = 226.3 5mg QQ客服:2056216494
    Byzantionoside B; Byzantionoside B CFN99871 189109-45-3 C19H32O7 = 372.5 5mg QQ客服:215959384
    Dehydrovomifoliol; Dehydrovomifoliol CFN89279 39763-33-2 C13H18O3 = 222.28 5mg QQ客服:1413575084
    Boscialin; Boscialin CFN89022 129277-03-8 C13H22O3 = 226.31 5mg QQ客服:215959384
    Glochidionionol C; Glochidionionol C CFN89291 N/A C13H20O3 = 224.30 5mg QQ客服:1457312923
    吐叶醇; Vomifoliol CFN98245 23526-45-6 C13H20O3 = 224.3 5mg QQ客服:2056216494
    长寿花糖甙; Roseoside CFN98916 54835-70-0 C19H30O8 = 386.4 5mg QQ客服:215959384

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