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  • 3',4',7-三羟基异黄酮

    3',4',7-Trihydroxyisoflavone

    3',4',7-三羟基异黄酮
    产品编号 CFN70376
    CAS编号 485-63-2
    分子式 = 分子量 C15H10O5 = 270.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Crotalaria pallida.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3',4',7-三羟基异黄酮 CFN70376 485-63-2 1mg QQ客服:3257982914
    3',4',7-三羟基异黄酮 CFN70376 485-63-2 5mg QQ客服:3257982914
    3',4',7-三羟基异黄酮 CFN70376 485-63-2 10mg QQ客服:3257982914
    3',4',7-三羟基异黄酮 CFN70376 485-63-2 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • The Ohio State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2022, 13:806869.
  • J Biochem Mol Toxicol.2021, 35(5):e22731.
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Front Pharmacol.2019, 10:1226
  • Molecules2022, 27(14):4601
  • Auburn University2015, 1-58
  • Evid Based Complement Alternat Med.2020, 2020:1970349.
  • Research on Crops.2017, 18(3):569
  • Pharm Biol.2016, 54(7):1255-62
  • Sci Rep. 2017, 17332(7)
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Molecules.2018, 23(7):E1659
  • Nutrients.2021, 13(8):2901.
  • J Ethnopharmacol.2017, 206:73-77
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • Nat Commun.2019, 10(1):5169
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Biomed Pharmacother.2020, 128:110318.
  • Int J Oncol.2019, 55(1):320-330
  • J Nat Med.2017, 71(4):745-756
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • Molecules.2019, 24(16):E2985
  • ...
  • 生物活性
    Description: 3',4',7-Trihydroxyisoflavone has antioxidant, estrogenic, and chemoprotective activities, it inhibits the CK-II-mediated phosphorylation of 60S acidic ribosomal P proteins in vitro. CDKs and PI3K are the primary molecular targets of 3',4',7-Trihydroxyisoflavone in the suppression of EGF-induced cell proliferation. 3',4',7-Trihydroxyisoflavone nanoparticles are characterized by improved physicochemical properties, increased water solubility, and enhanced skin penetration, and these may have potential use in the future as a topical delivery formulation for the treatment of skin diseases.
    Targets: CDKs | PI3K | p35 | EGFR | GSK-3β | Akt | AP-1
    In vitro:
    International Journal of Nanomedicine,2016, 2016(11): 1615—1627.
    Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration.[Reference: WebLink]
    7,3',4'-Trihydroxyisoflavone (3',4',7-Trihydroxyisoflavone, 734THIF) is a secondary metabolite of daidzein and has been recently found to possess antioxidant, melanin inhibition, and skin cancer chemopreventive activities. However, the poor water solubility of 734THIF impedes its absorption and skin penetration and, therefore, limits its pharmacological effects when applied topically to the skin.
    METHODS AND RESULTS:
    We seek to use the nanoprecipitation method to prepare optimal eudragit E100 (EE)–polyvinyl alcohol (PVA)-loaded 734THIF nanoparticles (734N) to improve its physicochemical properties and thereby increase its water solubility, skin penetration, and biological activities. EE–PVA-loaded 734THIF nanoparticles (734N) were prepared, and their morphology and particle size were evaluated using a particle size analyzer and by electron microscopy. The drug loading and encapsulation efficiencies and in vitro solubility were determined using high-performance liquid chromatography. Hydrogen-bond formation was evaluated by 1H-nuclear magnetic resonance and Fourier transform infrared spectroscopy, and crystalline-to-amorphous transformation was determined by differential scanning calorimetry and X-ray diffractometry. In vitro skin penetration was analyzed using fresh pig skin mounted on Franz diffusion cells, and cytotoxicity against human keratinocyte HaCaT cells was evaluated using the MTT assay. Antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl-free radical scavenging ability. EE–PVA-loaded 734THIF nanoparticles showed good drug loading and encapsulation efficiencies and were characterized by improved physicochemical properties, including reduction in particle size, amorphous transformation, and intermolecular hydrogen-bond formation. This is associated with increased water solubility and enhanced in vitro skin penetration, with no cytotoxicity toward HaCaT cells. In addition, 734THIF nanoparticles retained their antioxidant activity.
    CONCLUSIONS:
    In conclusion, 734THIF nanoparticles are characterized by improved physicochemical properties, increased water solubility, and enhanced skin penetration, and these may have potential use in the future as a topical delivery formulation for the treatment of skin diseases.
    Food Chemistry, 2012, 134(1):282-287.
    Isoflavone C-glycosides isolated from the root of kudzu (Pueraria lobata) and their estrogenic activities.[Reference: WebLink]

    METHODS AND RESULTS:
    The chemical structures of six isoflavones (1–6) isolated from the kudzu root (Pueraria lobata) were elucidated on the basis of the NMR and MS analyses to be four isoflavone C-glycosides as 6″-O-α-d-glucopyranosylpuerarin (1), puerarin (2), 3′-methoxypuerarin (3), 6″-O-α-d-apiofranosylpuerarin (4), and two aglycons as biochanin A (5) and formononetin (6), respectively. The estrogenic activities of isolated compounds and related isoflavones were evaluated using a yeast two-hybrid assay. Genistein exhibited the highest activity among the evaluated compounds at 10−6 M followed by daidzein (10−5 M), baiochanin A (5) (10−5 M), daidzin (10−5 M), 3',4',7-Trihydroxyisoflavone(10−3 M), and formononetin (6) (10−2 M). The isoflavone C-glycosides (1–4) and 4′,7-dimethoxyisoflavone showed no activities.
    CONCLUSIONS:
    In these results, it was found that the addition of 8-C-glucose or 3′-hydroxyl group to daidzein skeleton, or the substitution of hydroxyl functions to methoxyl groups, decreased the estrogenic activity of daidzein, on the other hand, the addition of 7-O-glucose moiety had no influence on the activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.701 mL 18.5048 mL 37.0096 mL 74.0192 mL 92.5241 mL
    5 mM 0.7402 mL 3.701 mL 7.4019 mL 14.8038 mL 18.5048 mL
    10 mM 0.3701 mL 1.8505 mL 3.701 mL 7.4019 mL 9.2524 mL
    50 mM 0.074 mL 0.3701 mL 0.7402 mL 1.4804 mL 1.8505 mL
    100 mM 0.037 mL 0.185 mL 0.3701 mL 0.7402 mL 0.9252 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    次野鸢尾黄素; Irisflorentin CFN99788 41743-73-1 C20H18O8 = 386.35 20mg QQ客服:1457312923
    野鸢尾黄素; Irigenin CFN93276 548-76-5 C18H16O8 = 360.31 20mg QQ客服:3257982914
    Isolupalbigenin; Isolupalbigenin CFN96522 162616-70-8 C25H26O5 = 406.48 5mg QQ客服:2159513211
    Isoangustone A; Isoangustone A CFN96505 129280-34-8 C25H26O6 = 422.47 5mg QQ客服:1413575084
    Pierreione B; Pierreione B CFN96543 1292766-21-2 C26H28O7 = 452.50 5mg QQ客服:3257982914
    3',4',7-三羟基异黄酮; 3',4',7-Trihydroxyisoflavone CFN70376 485-63-2 C15H10O5 = 270.2 5mg QQ客服:3257982914
    毛蕊异黄酮; Calycosin CFN99140 20575-57-9 C16H12O5 = 284.26 20mg QQ客服:2056216494
    3'-甲氧基大豆黄素; 3'-Methoxydaidzein CFN96186 21913-98-4 C16H12O5 = 284.3 5mg QQ客服:2056216494
    3',4',5,7-四羟基异黄酮; Orobol CFN98737 480-23-9 C15H10O6 = 286.2 5mg QQ客服:1413575084
    3'-O-甲基香豌豆苷元; 3'-O-Methylorobol CFN98492 36190-95-1 C16H12O6 = 300.3 5mg QQ客服:3257982914

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