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  • 3,4,5-三甲氧基肉桂酸

    3,4,5-Trimethoxycinnamic acid

    3,4,5-三甲氧基肉桂酸
    产品编号 CFN98182
    CAS编号 90-50-6
    分子式 = 分子量 C12H14O5 = 238.24
    产品纯度 >=98%
    物理属性 White cryst.
    化合物类型 Phenylpropanoids
    植物来源 The heartwoods of Cassia garrettiana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,4,5-三甲氧基肉桂酸 CFN98182 90-50-6 10mg QQ客服:1413575084
    3,4,5-三甲氧基肉桂酸 CFN98182 90-50-6 20mg QQ客服:1413575084
    3,4,5-三甲氧基肉桂酸 CFN98182 90-50-6 50mg QQ客服:1413575084
    3,4,5-三甲氧基肉桂酸 CFN98182 90-50-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
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  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Appl. Sci. 2021, 11(8),3437.
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  • ...
  • 生物活性
    Description: 3,4,5-Trimethoxycinnamic acid has anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. It shows hypoxia inducible factor-2 (HIF-2) inhibitory activity with EC50 value of 60.6 uM. 3,4,5-Trimethoxycinnamic acid derivatives have a potential antinarcotic effect through acting as a 5-HT(1A) receptor agonist in mice.
    Targets: 5-HT Receptor | ERK | GABA Receptor | HIF-2
    In vivo:
    Chem Biol Drug Des. 2013 Mar;81(3):389-98.
    Synthesis and evaluation of a series of 3,4,5-trimethoxycinnamic acid derivatives as potential antinarcotic agents.[Pubmed: 23121934]
    A series of 3,4,5-trimethoxycinnamic acid derivatives was prepared and evaluated for antinarcotic effects on morphine dependence in mice and binding affinities on serotonergic receptors.
    METHODS AND RESULTS:
    The key synthetic strategies involve generation of ketones 6-7, esters 9-12 through condensation reaction, and amides 13-19 via coupling reaction using 1-hydroxybenzotriazole/ethyl(dimethylaminopropryl)carbodiimide system in high yield. We found that the naloxone-induced morphine withdrawal syndrome was significantly suppressed by new synthetic 3,4,5-trimethoxycinnamic acid derivatives (20 mg/kg/day). Most of 3,4,5-trimethoxycinnamic acid derivatives were found to have high affinity to 5-HT(1A) receptor. The naloxone-induced morphine withdrawal syndrome was attenuated by (+)8-OH-DPAT (0.1 mg/kg/day, i.p.), a 5-HT(1A) receptor agonist. In cortical neuronal cells, (+)8-OH-DPAT (1 μM) produced an elevation of the pERK 1/2 expression, and the elevated pERK levels were inhibited by WAY 100635, a 5-HT(1A) receptor-specific antagonist. Interestingly, the pERK levels were increased by the 3,4,5-trimethoxycinnamic acid derivatives and the derivatives-mediated changes in pERK levels were blocked by the WAY 100635.
    CONCLUSIONS:
    These results suggested that new synthetic 3,4,5-trimethoxycinnamic acid derivatives have a potential antinarcotic effect through acting as a 5-HT(1A) receptor agonist in mice.
    Biol Pharm Bull. 2004 Aug;27(8):1317-9.
    Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji).[Pubmed: 15305046]
    3,4,5-trimethoxycinnamic acid (TMCA) is one of the constituents in Onji (roots of Polygala tenuifolia WILLD), an herbal medicine used for sedative in Japanese traditional Kampo medicine. Our previous study revealed that oral administration of this compound prolongs sleeping time induced by hexobarbital in mice to exhibit sedative action.
    METHODS AND RESULTS:
    In the present study, we investigate the effects of TMCA on the stress induced with repeated cold exposure or intracerebroventricular injection of corticotrophin-releasing hormone (CRH). Both types of stress significantly reduced the sleeping time induced with pentobarbital in rat, which was significantly prolonged by intraperitoneal injection of TMCA. The intracerebroventricular injection of CRH significantly augmented the content of norepinephrine (NE) in locus coeruleus (LC) of rats, which was significantly suppressed by the intracerebroventricular injection of TMCA.
    CONCLUSIONS:
    These findings suggest that TMCA would exhibit sedative effects by suppressing NE content in LC.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1974 mL 20.9872 mL 41.9745 mL 83.949 mL 104.9362 mL
    5 mM 0.8395 mL 4.1974 mL 8.3949 mL 16.7898 mL 20.9872 mL
    10 mM 0.4197 mL 2.0987 mL 4.1974 mL 8.3949 mL 10.4936 mL
    50 mM 0.0839 mL 0.4197 mL 0.8395 mL 1.679 mL 2.0987 mL
    100 mM 0.042 mL 0.2099 mL 0.4197 mL 0.8395 mL 1.0494 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式-5-羟基阿魏酸; trans-5-Hydroxyferulic acid CFN70250 110642-42-7 C10H10O5 = 210.2 5mg QQ客服:1457312923
    芥子醇; Sinapyl alcohol CFN91507 537-33-7 C11H14O4 = 210.2 20mg QQ客服:1413575084
    反-3,5-二甲氧基-4-羟基肉桂醛; trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde CFN70106 4206-58-0 C11H12O4 = 208.2 20mg QQ客服:2159513211
    3,5-二甲氧基-4-羟基肉桂酸,芥子酸; Sinapic acid CFN92631 530-59-6 C11H12O5 = 224.2 20mg QQ客服:2159513211
    芥子酸甲酯; Methyl sinapate CFN97787 20733-94-2 C12H14O5 = 238.24 20mg QQ客服:2159513211
    3,4,5-三甲氧基肉桂酸; 3,4,5-Trimethoxy-trans-cinnamic acid CFN92506 20329-98-0 C12H14O5 = 238.2 20mg QQ客服:3257982914
    3,4,5-三甲氧基肉桂酸; 3,4,5-Trimethoxycinnamic acid CFN98182 90-50-6 C12H14O5 = 238.24 20mg QQ客服:1457312923
    3,4,5-三甲基肉桂酸甲酯; Methyl 3,4,5-trimethoxycinnamate CFN97691 7560-49-8 C13H16O5 = 252.26 20mg QQ客服:215959384
    2,3,4-三甲氧基肉桂酸; trans-2,3,4-Trimethoxycinnamic acid CFN98189 33130-03-9 C12H14O5 = 238.24 20mg QQ客服:2159513211
    Secodihydro-hydramicromelin B; Secodihydro-hydramicromelin B CFN97911 1212148-58-7 C15H18O8 = 326.3 5mg QQ客服:1457312923

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